Vanesa Cepas López

🚨ECRs apply to the PhD Symposium! Best presentations will be awarded a free registration for SFRR-E conference 2026 in Mainz! You have all the info in the SFRR-E intranet!

New biosensor for REDOX lovers! Scientists at VIB, Daria Ezeriņa and Joris Messens, with global partners, developed HyPerFLEX🌈!

@messenslab.bsky.social

REVIEW🚨
The authors discuss the regulation and interplay of the metabolic #CellDeath pathways #ferroptosis, #disulfidptosis and #cuproptosis and explore how these mechanisms can be harnessed for cancer therapies.
@mdanderson.bsky.social
📖 ⬇️
https://bit.ly/3L3vN...

🚨New paper published today on cancer bugs and drugs!🚨

“Chemotherapy modulation by a cancer-associated microbiota metabolite”

Congrats to the Cabreiro lab on this exciting study!
#Cancer #Microbiome #Metabolism #Chemotherapy
#MRC_LMS #ImperialCollege #CECAD_Cologne

www.cell.com/cell-systems...

The @sfrre-ecr.bsky.social webinar series is back! You can't miss tomorrow's talks by @avdar66.bsky.social and Thibaut Vignane for some exciting insights about Redox Regulation in Cellular Aggregates 🚀

🚀New preprint w/ @roberto_amv: We used chemogenetics to precisely control mitochondrial H2O2 in skeletal muscle in vivo. This exposes a dose-dependent sequence: translation suppression → proteolysis → denervation-like → degeneration @tejensen23 www.biorxiv.org/content/10.1...

Metabolic regulation of key developmental events during mammalian embryogenesis - Nature Cell Biology This Review discusses the intricate relationship between metabolism and embryogenesis, highlighting the orchestration of key developmental processes by metabolites and signalling molecules that provid...

🍹Interested in #DevBio and #metabolism ? This Review discusses the relationship between metabolism and embryogenesis!
👉https://rdcu.be/eCHvJ

bit.ly/4oVnB4t

A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision ROS oxidize cell cycle proteins and regulate cell proliferation. Vorhauser et al. show that oxidation of the cyclin-dependent kinase (CDK) inhibitor p21 at cysteine 41 (C41) during the G2 phase contro...

I am very happy to share that my PhD work in the Mansfeld lab (www.mansfeldlab.com) was published yesterday! 🎉 In this study, we characterized a novel redox switch on p21 that regulates proliferation: www.cell.com/molecular-ce...
Huge thanks to everyone involved for making this possible 🙏@icr.ac.uk

If you’re looking for a wonderful postdoc experience plus exciting project, this is the place!

This is great news! Congratulations Pedro! 🎉🎉

Save the dates!

Emerging Trends for the Regulation of Thiol-Based Redox Transcription Factor Pathways Thiol-based redox transcription factor pathways play central roles in the cellular response to peroxide stress. We review the bacterial OxyR, yeast AP-1 and mammalian NRF2/Keap1 systems and the princi...

Happy to share our review paper, "Emerging Trends for the Regulation of Thiol-Based RedoxTranscription Factor Pathways" doi.org/10.1021/acs.... It was fun learning about the really cool science being undertaken by some excellent labs. Thanks, ACS Biochemistry, for the invite.

Don't miss it !

🧪 The 2nd FEBS Redox Medicine Workshop will explore how the exposome—diet, chemicals, microbes & more—modulates redox regulation in health & disease. From tools to therapies, talks span redox in metabolism, epigenetics, transcription, cell death & beyond.

#Redox #Exposome #FEBS

Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...

🎉Excited to share our latest paper, published in Nature Communications!🎉

"Enhancing autophagy by redox regulation extends lifespan in Drosophila"

#redox #metabolism #ageing #Drosophila

@natcomms.nature.com @mrc-lms.bsky.social

doi.org/10.1038/s414...

🎉 Exciting news! I’ve been awarded an ECR seed grant from SFRR-E! It supports early career researchers in launching new projects and generating preliminary data for future grant applications. Grateful for the support and looking forward to getting started!
🔗 www.sfrr-europe.org/index.php/aw...

Organelle conversations drive ferroptosis - Nature Cell Biology Ferroptosis begins with phospholipid peroxidation, leading to membrane damage rupture and cell death. Although research has surged, the intracellular site for ferroptosis initiation remains uncertain....

Organelle conversations drive ferroptosis -

news and views on a recent study by @mariamls.bsky.social and colleagues

www.nature.com/articles/s41...

Want to apply for a Marie Skłodowska-Curie Fellowships to work with us? Apply: cimus.usc.gal/jobs/marie-s...

The metabolic code of ferroptosis: nutritional regulators of cell death Ferroptosis is a distinctive form of regulated cell death driven by iron-dependent phospholipid peroxidation. Its initiation and suppression are finel…

New review together with
@k-hadian.bsky.social group-

Have fun reading!
#ferroptosis #nutrition #celldeath

www.sciencedirect.com/science/arti...

CD44 and SLC1A2 are commonly regulated but do not form a fusion transcript in ER+ breast cancer - Molecular and Cellular Biochemistry Endocrine therapy (ET) is essential for managing ER+ HER2− breast cancer; however, resistance remains a significant clinical challenge. This study investigated whether CD44-SLC1A2 gene fusions, report...

.🧬We looked for a CD44:SLC1A2 fusion in breast cancer. The data said no. Instead of shelving it, we published.
📢 Now out in @SpringerNature MCB: link.springer.com/article/10.1...
Negative results matter. Transparency matters. Proud of this one 🥳! #OpenScience

🚨🚨The call for the new edition of the Mentoring Program is open. You can apply as a mentor or mentee through the SFRR-E intranet, it only takes 10 minutes!

Thiol-based redox switches: From chemistry to physiology and pathology Redox reactions have been essential for the emergence of life on Earth, and diverse strategies have evolved for responding to various cellular redox species. These mechanisms are still of vital impor…

The @EMBO workshop #EMBOthiolSwitches is coming up soon, join us in beautiful Sant Feliu de Guíxols, Spain, 13–18 September 2025!
We have a fantastic speaker lineup, with a few spots still open for short talks. Abstract deadline extended to 31 May 2025.

meetings.embo.org/event/25-thi...

New Professor position at Saarland University for Cell Physiology!

A new tool from our lab :-). Together with the Brachvogel, Bogeski and Mielenz labs. We developed a genetically encoded sensor to monitor activity of the dipeptidases DPP8 and DPP9 in cells allowing us to ask fundamental questions about their spatiotemporal regulation. DOI: 10.26508/lsa.202403076

Lipid-degrading small molecule kills cancer cells by ferroptosis A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.

Excited to see our N&V w/ @mikelangelipid.bsky.social published in Nature, highlighting new work from Raphael Rodriguez and team. A heterofunctional molecule that activates lysosomal iron triggers lipid peroxidation and ferroptosis in therapy-resistant cancer cells. www.nature.com/articles/d41...

Monitoring subcellular NADP redox state with NAPstar biosensors

Monitoring subcellular NADP redox state with NAPstar biosensors @riemerlab.bsky.social @morganlab-saarland.bsky.social
@jan-oleniemeier.bsky.social

www.sciencedirect.com/science/arti...

📢 Exciting Webinar Alert!

Join us tomorrow, April 1st, at 15:00 CET for an unmissable webinar on chaperones in redox biology, hosted by @sfrre-ecr.bsky.social! We’re thrilled to welcome two fantastic speakers: @ulrichlab.bsky.social and @rsutandy.bsky.social.
See you there!

I am delighted to be in London next month for the UK Redox Network! If you would like to join us, there is still time to register forms.office.com/e/8Zt9Kq2dag! I am very thankful for the opportunity to talk about my work (two years in a row)! Hopefully I wont be broken this time, just jet lagged...

📢 We are seeking candidates to apply for the PhD fellowship FI-STEP from AGAUR with us!
💊 You will work on #MedChem projects for cancer, combining organic chemistry and some biology.
🌍 Due to the call's requirements, you must have European citizenship.
Get in touch!

Microscopy preprints - bioimage analysis - FocalPlane Microscopy preprints - bioimage analysis - News

📢Our latest #preprint list is up on FocalPlane.
This week we focus on bioimage analysis tools and their application in biology.
focalplane.biologists.com/2025/03/07/m...

❓ Tired of searching for funding?

We’ve done the hard work for you with our Physiology Grants Directory. 💡 View all the grants currently available, or coming up, for all career stages! Check it out now ➡️ https://buff.ly/40X0dZ9

#Grants #FundingOpportunities #ResearchFunding