William Hill

Of Barriers and Loops—How Evolution Limits Most Cancer Risks to Older Ages url: aacrjournals.org/cancerdiscov...

Critical role for a high-plasticity cell state in lung cancer - Nature The high-plasticity cell state (HPCS) is a critical hub that enables reciprocal transitions between cancer cell states, and targeting the HPCS may suppress cancer progression and eradicate treatment r...

Incredible work demonstrating a functional role for malignant cell states in preclinical lung cancer models
www.nature.com/articles/s41...

Cytokines are tricky to study, let alone in vivo. New tool to study cells that respond to cytokine receptor activation

It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social

Paul Nurse describing the main job of a PI

(From ‘The Thinking Game’, 2024)

6 incredible years. So grateful for the opportunity to work with such brilliant people. What an adventure. Goodbye @crick.ac.uk

Diagram illustrating the two-hit model of retinoblastoma

To better treat cancer, we need to understand its underlying biology. Despite decades of research, some fundamental questions remain unanswered. One is why certain key tumor suppressor or oncogenes lead to cancer predominantly in single tissue: e.g. Rb in the retina, or APC in the colon 1/n 🧪

Thank you!!

Thanks Helen! Definitely!

Thank you! Hopefully cross paths soon!

Thrilled to announce I'm moving to Manchester to lead the Cancer Origins group! If you're interested in how mutations and exposures drive tumourigenesis — come join the adventure

William Hill is presenting his work on air pollutants in lung adenocarcinoma in a fascinating session exploring ageing and environmental factors in the development and spread of lung cancer.

#AACR25 | @drwilliamhill.bsky.social | @crick.ac.uk

Very interesting, I hadn't seen this. I know p53 mutations occur in normal lung tissue. Will be interesting to test the association of presence/absence of p53 mutations and expansion/selection of those mutations in people who smoke and those who don't.

Translating premalignant biology to accelerate non-small-cell lung cancer interception - Nature Reviews Cancer While progress has been made in treating advanced non-small-cell lung cancer, patients would further benefit from methods that detect progressive premalignant lesions and strategies that effectively i...

Fantastic insight into NSCLC, going from biology to interception

Simultaneous immunomodulation and epithelial-to-mesenchymal transition drives lung adenocarcinoma progression Lung cancer remains the deadliest cancer in the United States, with lung adenocarcinoma (LUAD) as its most prevalent subtype. While computed tomography (CT)-based screening has improved early detectio...

Imaging mass cytometry of 122 early stage lung adeno patients explores the balance of of the tumour microenvironment and changes in malignant cell fate.

New to bluesky, but I’m excited to share my work over the last few years with @jbuenrostro.bsky.social! Chronic inflammation creates an epigenetic memory in colonic stem cells, priming them for tumor growth: tinyurl.com/ColitisNagar.... Here’s a walkthrough of what we found (🧵)

A manifesto for the simple scribe – my 25 commandments for journalists | Tim Radford Former Guardian science editor, letters editor, arts editor and literary editor Tim Radford has condensed his journalistic experience into a handy set of rules for aspiring hacks

It is with great sadness to hear that the great Tim Radford has died. He was, unequivocally, the best science journalist, and a kind and generous man. I used his Manifesto for the Simple Scribe in lectures for student this very week. It’s faultless.

www.theguardian.com/science/blog...

I had a fantastic day at the CRUK workshop last week at the intersection between aging and cancer.

That's cool

At individual level those who vape more likely to go on to smoke (but causality not proven) but at population level higher levels of youth vaping could mean lower levels of youth smoking - really important work from @jhb19.bsky.social showing how carefully we need to keep the evidence under review

Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis Background The risk of developing advanced neoplasia (AN; colorectal cancer and/or high-grade dysplasia) in ulcerative colitis (UC) patients with a low-grade dysplasia (LGD) lesion is variable and dif...

Today our study using copy number alterations (CNAs) from low-coverage WGS to predict FUTURE colorectal cancer in patients with IBD is published, details in thread! 1/5
gut.bmj.com/content/earl...

Concurrent PIK3CA mutant drives cachexia through inflammatory signaling in EGFR mutant lung cancer PIK3CA mutation is frequently concurrent with known oncogenic drivers such as EGFR mutation in lung cancer, raising an interesting question about its real function. Cachexia is a systemic disease invo...

One of my frustrations with our work to understand the causes of #cancer #cachexia as part of Cancer Grand Challenges Team #CANCAN is the limitation of animal models that don't reflect the realities of the patient population. This development helps. #LCSM #lungcancer

www.biorxiv.org/content/10.1...

Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma

https://buff.ly/4akMe3C

While further prospective validation is required, this approach could significantly enhance risk stratification and treatment planning in early-stage LUAD.

A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis - Nature Immunology Blander and colleagues report a homeostatic regulatory effect played by inflammasomes in the bone marrow stromal compartment that suppresses premalignant stages of lymphomagenesis.

Ever wonder if the innate immune system protects against cancer in premalignancy? My lab reports that the inflammasome in bone marrow stroma suppresses Ras in preleukemic stem cells restraining lymphomagenesis.

Happy to share here: www.nature.com/articles/s41...

Launch of world’s most significant protein study set to usher in new understanding for medicine

I'm delighted to announce that the Pharma Proteomics Project will commence full-scale proteomic profiling of the UK Biobank in 2025. We have selected the Olink Proteomics Explore HT platform and Ultima Genomics UG 100 sequencers for this unprecedented study.

www.ukbiobank.ac.uk/learn-more-a...

Reinventing type 2 immunity in cancer - Nature This Review addresses the roles of type 2 immunity in cancer and the potential for cancer immunotherapies targeting this pathway.

"unlike type 1 immune responses, type 2 immunity is perceived as a potential promoter of tumorigenesis. Emerging evidence challenges this perspective, painting a more nuanced picture in which type 2 immunity might protect against or even actively suppress tumour growth and progression." #ImmunoSky

Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations - Nature Cell Biology Hemalatha et al. track the endogenous redox ratio (NAD(P)H/FAD) with live imaging in the mouse skin to study the interface of wild-type stem cells with oncogenic mutant cells. They find that maintaini...

Metabolic changes at the interface between mutant and normal skin epidermis www.nature.com/articles/s41...

But also who will I listen to the Rest is politics with in ex3?!

Congratulations!

Acquisition of discrete immune suppressive barriers contributes to the initiation and progression of preinvasive to invasive human lung cancer. https://www.biorxiv.org/content/10.1101/2024.12.31.630523v1