Ian Kelsall

"I DON'T NEED YOU TO FUCKING REWRITE WHAT I'VE JUST WRITTEN!"

This morning my ChatGPT quota was inexplicably exhausted.

It took a while but I pieced it together. Voice mode somehow got activated when I went to bed.

The bot then engaged in a 10 hour conversation with my snoring dog, answering questions the pup wasn’t asking and praising him for his insight.

But surely IV would have rendered it 4, causing much confusion amongst the music buying public?

The last population of woolly mammoths became extinct nearly 1,000 years after the Great Pyramid of Giza was completed. Theoretically many of Eygpt's pharaohs could have hunted mammoth, had they possessed the means to travel so far north.

A good day to remember John Gurdon’s school report from his biology master at Eton

Get in loser, we’re going to the rapture.

A CAPTCHA layout with the central Bosch triptych from The Last Judgement: Select all squares with THE DAMNED If there are none, click skip

RAPTCHA

If you enjoyed Blood Meridian then I might suggest "The Son" by Philipp Meyer. Perhaps not as gore filled, but still a pretty brutal cowboy romp. Oh, and "Waiting for the Barbarians" by JM Coetzee is a book I would recommend to anybody who will listen!

Vintage 1960s 1970s Arrow pointer for slide projections - Vintagelens Vintage 1960s 1970s Arrow pointer for slide projections tested and working

Indestructible and difficult to misplace I guess. It looks like second-hand ones can still be picked up quite cheap in Ebay etc. I'd naïvely assumed that everybody just used a big stick to point before the arrival of the laser pointer!
vintagelens.nl/product/vint...

Look at the size of that pointer! That thing looks like a lightsabre.

The rise of ADP-ribose–ubiquitin Nature Structural & Molecular Biology - Post-translational modifications show mechanistic crosstalk, exemplified by the ADP-ribose–ubiquitin hybrid signal, in which one post-translational...

A few years back we discovered a dual hybrid protein modification composed of an ADP-ribose dinucleotide and the ubiquitin moieties (ADPr-Ub). Here you can read our review that will give you an update on this increasingly popular topic:
rdcu.be/eETIT

Art class

From the latest Private Eye, out now.

Congratulations Sonja!

FACT OF THE DAY. 2 September 1752. Britain replaced the Julian calendar with the Gregorian one which was used in most of Europe. The following day was 14 September 1752, meaning 11 days were cut from the 1752 British calendar. These days simply never existed.

Your mam shouts at hotels and your dad paints roundabouts

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.

www.nature.com/articles/s41...

Congratulations!

A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles Grabarczyk et al. show the structure and mechanism of a non-canonical ubiquitin ligase, which is activated through nucleic-acid-induced oligomerization and is critical for cell survival during immune ...

Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social
www.cell.com/cell/fulltex...

ZNFX1 compacts and tags RNA to keep immunity in check Tim Clausen’s lab at the IMP and collaborators have uncovered how the ancient immune protein ZNFX1 enables cells to walk the fine line between fighting infection and avoiding autoimmune damage. The te...

Scientists uncovered how the immune protein ZNFX1 enables cells to walk the fine line between fighting infection & avoiding autoimmune damage. ZNFX1 can ubiquitinate & compact host & viral RNA into molecular condensates, extending ubiquitin biology to RNA itself. More: www.imp.ac.at/news/article...

President @realDonaldTrump showing President Zelenskyy and President Macron his 4 More Years hat 🤣🇺🇸

Showing the endangered leader of an invaded country my hats

a man with dreadlocks and a beard is making a funny face while wearing a white tank top . ALT: a man with dreadlocks and a beard is making a funny face while wearing a white tank top .

Oh no thank you! Insects should not be that big!

Ozzy Osbourne being Ozzy Osbourne.

An incomparable legend.

Installing microwave ovens is hardly a tough gig is it? Put it on the worktop, plug it in- bosh. Money for nothing #liveaid

Who's that weird man with Olivia Rodrigo daddy?
Oh, that's Robert Smith. He wrote this.
But why is he dressed like a horror clown?
Erm...
#Glastonbury2025

How a discovery in Yellowstone National Park led to the development of PCR - Richmond Scientific A discovery in Yellowstone National Park led to the development of PCR, the gold-standard COVID-19 tests used to fight the global pandemic.

Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...

A great song, but those lyrics about "the touch of the younger kind" have not aged well.

Thanks Simon, it was great to meet you too (even if it was only briefly)!

Here's today's train tour scribble after reading this headline about Andrew Tate - 'one in six boys aged six to fifteen have a positive view of andrew tate' x x x five in six boys think andrew tate is a prick the headline reads: one in six boys aged six to fifteen have a positive view of andrew tate the headline does not read: five in six boys think andrew tate is a prick prefer riding their bike into town with their mates than listening to a grown up angrily shout through a screen five in six boys think their mum is alright roll their eyes when she hugs them will remember the sound of her laugh when she's gone five in six boys have baked biscuits or muffins do not want to strangle a girlfriend, think rape is abysmal, want love, think love is confusing, do not want a fist in their face five in six boys think their dad's jokes are occasionally funny, have a friend who likes the same music they like, worry about the look of their bodies in swim shorts love the feeling of crying from laughter five in six boys feel nervous about holding the hand of a crush privately cry when a person they fancy doesn't fancy them back without seeking to hurt them five in six boys are worried they'll fail their exams feel stupid sometimes, are scared by the thought of the future five in six boys think flowers are beautiful will not use the word beautiful will be bullied if they use the word beautiful about flowers still, five in six boys said thank you for dinner helped take the plates to the kitchen smile when a kitten curls up on their lap sleep sounder when someone who loves them plants a kiss on their forehead or just quietly whispers goodnight

I absolutely love this poem by @holliemcnish.bsky.social – 5 in 6 boys think Andrew Tate is a prick