Juan Zapata-Muñoz

Structure of the ULK1C core.

CRN Team Hurley determined the cryo-electron microscopy structure of the human ULK1C core at amino-acid-level resolution. They examined the ULK1C core in complex with another autophagy core complex, the class III PI3KC3-C1.

🔗 Read the full #publication: www.nature.com/articles/s41594-025-01557-x

Join us! Research Technician position available with Dario Alessi www.ppu.mrc.ac.uk/careers/recr...

Special Issue: Cell Biology of Mitochondria - MitoWorld The special issue of Journal of Cell Science (JCS) on the “Cell Biology of Mitochondria” looks to be one of the most comprehensive open series of papers, opinions, perspectives, interviews, reviews an...

A must-read for anyone in mitochondria research!

Journal of Cell Science has released a Special Issue on the Cell Biology of Mitochondria - articles, reviews, and expert insights covering dynamics, disease, and more!

View our summary mitoworld.org/special-issu...

Collaboration Expands Research Tool to Help Crack the Code on Parkinson’s and Other Neurodegenerative Diseases A new view of Parkinson’s disease

Parkinson’s disease is the fastest growing neurodegenerative condition.

Now researchers have a powerful new tool, thanks to a collaboration with @asapresearch.parkinsonsroadmap.org. Parkinson’s data is now available on the free and open ABC Atlas.

🧠 alleninstitute.org/news/a-new-v...

Your sleep pressure is powered by your mitochondria! Sleep, energy, and ageing are all connected through mitochondrial bioenergetics in neurons. Brilliant work from Gero Miesenböck’s lab, just out in Nature @nature.com
www.nature.com/articles/s41...

Inhibiting enzyme could halt cell death in Parkinson’s disease, study finds Stanford Medicine-led research in mice indicates that inhibiting the LRRK2 enzyme could stabilize patients with a type of Parkinson’s disease.

med.stanford.edu/news/all-new...

Looking forward to attending this fantastic meeting! 🔥

#CIBpapers

A team from @cib-csic.bsky.social discovered that deferiprone, used to eliminate excess iron in the body, protects retinal #photoreceptor cells from degeneration. 

🔗https://f.mtr.cool/lsxdqioyig

Deferiprone protects against photoreceptor degeneration by inhibiting parthanatos - Cell Death & Disease Cell Death & Disease - Deferiprone protects against photoreceptor degeneration by inhibiting parthanatos

🚨New paper alert! 🚨

🎓Proud to share this work as part of my PhD journey at Boya's Lab!

🧠We show that iron chelation protects against MNU-induced photoreceptor degeneration by inhibiting parthanatos

www.nature.com/articles/s41...

Trump proposes unprecedented budget cuts to US science Huge reductions, if enacted, could have ‘catastrophic’ effects on US competitiveness and the scientific pipeline, critics say.

Trump proposes unprecedented budget cuts for US science in next fiscal year
NASA cut by 24%
NIH cut by 40%
EPA cut by 55%
NSF cut by 56%
Analysis from @maxkozlov.bsky.social @dangaristo.bsky.social @alexwitze.bsky.social and @nature.com team
www.nature.com/articles/d41...

Do you LOVE organelles??
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!

Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy

🧵1/N

Cartel informando sobre el próximo congreso de SEFAGIA (del 29 al 31 de octubre, en Miraflores de la Sierra), con una fotografía del lugar donde se celebrará: La Cristalera. Image announcing the next SEFAGIA meeting (29-31 October, Miraflores de la Sierra), with a picture showing La Cristalera, the building where the meeting will take place.

📢📅 ¡Reservad las fechas!

El próximo congreso de SEFAGIA será en Miraflores de la Sierra (29-31 de octubre, Madrid).

Volviendo a nuestros orígenes…

----------

📢📅 Save the date!

Next SEFAGIA meeting will take place at Miraflores de la Sierra (29-31 October, Madrid).

Back to where it all began…

How and when to measure mitochondrial inner membrane potentials The scientific literature on mitochondria has increased significantly over the years due to findings that these organelles have widespread roles in the onset and progression of pathological conditions such as metabolic disorders, neurodegenerative and cardiovascular diseases, inflammation, and cancer. Researchers have extensively explored how mitochondrial properties and functions are modified in different models, often using fluorescent inner mitochondrial membrane potential (ΔΨm) probes to assess functional mitochondrial aspects such as protonmotive force and oxidative phosphorylation.

Mitochondria vibes only! Want to measure the inner membrane potential but unsure how or when? This review breaks it down! From protocols to pitfalls, get the tools you need to decode cellular powerhouses. ow.ly/Ejj050UsK7Y

Why Bax detection in >1400 publications might be flawed - Cell Death & Disease Cell Death & Disease - Why Bax detection in >1400 publications might be flawed

These studies are so important. Well done to the authors and the journal for publishing it. This certainly applies to so many antibodies. Companies selling antibodies should do and provide the right controls before commercialisation.

www.nature.com/articles/s41...

Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology

www.biorxiv.org/content/10.1...

Instead of listing my publications, as the year draws to an end, I want to shine the spotlight on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research.

Autophagy UK Network Meeting 2023 Visit the post for more.

autophagyuk389582434.wordpress.com

Postdoctoral position in the group of Dr. Antonio Martínez Ruiz in Madrid

Do you want to work as a #postdoc in our group in a Hospital Research Institute in Madrid?🏥🔬

Interested in how #mitochondria and #redox signalling/stress can influence #stroke outcome and #inflammation?🧠💊

Apply up to 26 December at n9.cl/iunkw (ref 72/2024)
Full call n9.cl/gijjd

Please repost 😉

Night science is all about being OPEN to new ideas, while Day science is all about being CLOSED in a particular experimental design. It’s crazy hard, but the full scientific process requires us to be good at both.

FMRP, MFF translation & mitochondrial fission in neurons ft. Adam Fenton, Ruchao Peng, @Charlie_R_Bond, @SHugelier, @melikel.bsky.social, @yiweichang.bsky.social, @erikaholzbaur.bsky.social & Thomas Jongens @BB_UPenn @penngenetics.bsky.social @cambupenn.bsky.social www.nature.com/articles/s41...

Madrid is an amazing city. Not if you're lower middle class and have to take the metro to work.

Just spent half an hour waiting to get on the metro in Madrid. I'm really looking forward to my PostDoc opportunity and leaving this city behind!! 🚇✈️ #Madrid #5YearsRelationship #Break-up

Color blind friendly palettes for data visualizations with categories A discussion of color blind friendly palettes for labeling unique catergories in data visualization.

Having a color-blind colleague is a good reminder that we need to be more careful when designing figures for scientific publication 🧪
My lab has found this page especially useful for selecting color palettes, used in combination with different symbols: thenode.biologists.com/data-visuali...

For Christmas…

Perception of Temperature Even in the Absence of Actual Change is Sufficient to Drive Transgenerational Epigenetic Inheritance Can processes occurring in one individuals nervous system influence the physiology of the descendants? Here we explored the provocative hypothesis that parents sensation or perception of environmental...

Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature *perception* can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance!
www.biorxiv.org/content/10.1...

Cover of the Journal of Cell Biology December 2024 issue, featuring the intricate dendritic arborization of large GABAergic neurons in new ER-phagy reporter mouse models, providing an unprecedented view of ER architecture.

Our December cover features the intricate dendritic arborization of large GABAergic neurons in new ER-phagy reporter mouse models, providing an unprecedented view of ER architecture (Sang et al. https://buff.ly/3D1uONe). JCB's Dec. Issue is here: https://buff.ly/4f3l7Lt

Apropos *first* post! We’ve discovered a central mechanism for how activation of STING induces NFkB related immune signaling - M1-linked/linear ubiquitin chains! I’m so excited to share it with you all, out now in t.co/zCIf2E4h2z a thread 1/X:

Updated comprehensive overview of protein interactions and protein modifications for your favorite protein!!

I wrote this some time back - ‘PhD is for training’

Learning resources for scientists · eLife A collections of articles that provide practical resources and guidance for researchers and academics

1/ 🧵 Free resources for scientists

💡 Covering research skills, careers, #SciComm, leadership, activism and more, everything in this thread appears on our Learning Resources page, with tips for researchers and academics at any career stage. #AcademicChatter #ECRChat
https://buff.ly/4f8vIpk

PINK1 controls RTN3L-mediated ER autophagy by regulating peripheral tubule junctions Domains of the ER are packaged into autophagosomes (macro-ERautophagy) during cell stress. Chidambaram et al. identify peripheral tubule junctions as a sit

PINK1 controls RTN3L-mediated ER autophagy by regulating peripheral tubule junctions rupress.org/jcb/article-...