Alex Gitlin

Congratulations to IMP faculty members Chryssie Brown @chrysothemisbrown.bsky.social and Alex Gitlin @gitlinlabmsk.bsky.social on receiving the 2025 Pershing Square Prize!! 🎉

G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation DNA G-quadruplexes (G4s) are non–B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork ...

How do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!

Splenic TNF-α signaling potentiates the innate-to-adaptive transition of antiviral NK cells NK cells possess innate and adaptive features, but unlike T and B cells, NK cells are not thought to require priming in lymphoid organs. Mujal et al. demonstrate that the spleen supports enhanced expa...

Congratulations to Dr. Adriana Mujal on this @cp-immunity.bsky.social study demonstrating a new role for an age old cytokine! www.cell.com/immunity/ful...

A figure showing a model for using BCR and TCR sequences to classify immunological disorders.

Attempting to read the language of B cell and T cell receptor sequences to diagnose immunological diseases:
Our new paper, led by the outstanding Maxim Zaslavsky @maximzaslavsky.bsky.social sky.bsky.social with help from me and Anshul Kundaje @anshulkundaje.bsky.social.
Link: buff.ly/3QvxSVf

Deep thanks to our many collaborators and all research participants. #immunology #science 🧪 @science.org @sarahhross.bsky.social

NIH funding was the lifeblood of this work, as it is for almost all biomedical discoveries and therapies in the U.S. @niaidnews.bsky.social

Hi everyone! Our team, the Cell Cyclers, are raising funds this year as part of #cycleforsurvival to support rare cancer research. 100% of donations will go to @mskcancercenter.bsky.social for this cause and are being matched dollar for dollar today! 🙏To donate:
secure2.convio.net/mskcc/site/T...

I’m proud to join more than 30 colleagues today in sharing our analysis of potential risks from “mirror life”. We summarize our findings in a @science.org article, and in greater detail in a 300pg technical report:

Article: www.science.org/doi/10.1126/...
Report: purl.stanford.edu/cv716pj4036

Regulation of human interferon signaling by transposon exonization Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.

I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪

Join the BCMB PhD program jointly run by Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center. Deadline December 1st, 2024.

If you are interested in pursuing a PhD in biomedical sciences in New York City, it is still time to apply to the BCMB program run jointly by Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center ! Deadline: Dec 1, 2024.

Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradation....

This is a very cool paper that I will add to my Mol Bio course. Specific tRNA recruitment of mRNA degradation complex to ribosome through the P site tRNA interactions with CCR4-NOT complex 1/ www.science.org/doi/10.1126/...

Pls share 🌟Join the IMP as a Group Leader
We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social
👉https://tinyurl.com/impgl2025

Our latest issue dropped. On the cover, the developmental biology of #dogs (and other mammal) noses!

🐶🧪

👉https://www.cell.com/current-biology/issue?pii=S0960-9822(23)X0023-2

radioactive gRNAs? could they enhance mutagenesis ... did anyone try this?!?