Ty Miller Lab

We also made a website and python API to run starCAT with several other published gene program catalogs including a myeloid reference from @tymillerlab.bsky.social et al and a hematapoetic stem cell reference from @bloodandtime.bsky.social and Hojun Li

UH Seidman Researcher Parlaying Findings in Nature into More Effective Immunotherapy for Brain Tumors, Targeting Myeloid Cells A major impediment to the successful use of immunotherapy in glioblastoma is the preponderance of a type of immune cell in the tumor, called myeloid cells, which can make up as much as 50% of all cell...

Case CCC/@uhcleveland.bsky.social researcher @tymillerlab.bsky.social targets myeloid cells in brain cancer www.uhhospitals.org/for-clinicia...

Home cooked meals are the best.
Grateful to have @vrishab_x's mother visit the lab from Seattle and cook us all authentic South Indian food for lunch today 😋❤️

Celebrating "UH100", the 100th brain tumor we've collected (in ~10 months!) & processed to learn more about these tumors & make patient organoids to test new therapies @uhreinstitute.bsky.social & @caseccc.bsky.social. Thanks to the patients, @staudtmd.bsky.social & Dr. Tiffany Hodges, & my lab!

Congratulations to @terminallycurious.bsky.social, Huang-lab MSTP student @CWRU, on her main thesis project!! Very happy we could help support her great story as our lab's first collaborative project. Turns out mechano-sensors are important in tumor-associated myeloid cells!
@caseccc.bsky.social

Piezo1 deletion enhances cross-priming of CD8+ T cells by tumor-infiltrating CD11b+ dendritic cells Background Tumor-associated myeloid cells (TAMCs) are an abundant, phenotypically plastic cell population that is critical for initiating a robust antitumor response. To properly combat cancer cells, ...

I am excited to share my work which demonstrates that deletion of PIEZO1 surprisingly enhances cross-priming in tumor-associated myeloid cells. Thank you to @tymillerlab.bsky.social for your critical collaboration and @sitcancer.bsky.social for publishing my story!

jitc.bmj.com/content/13/6...

Congratulations John! So well deserved!

Also, appreciate your voice and advocacy during this crazy time

This couldn't have better timing. Was just strategizing today with my MSTP student on creating a binder for a new target. Thanks for creating this!

Thanks! We have an online tool that will calculate the program usage in your cells. Just need your gene expression matrix. Will be more accurate than using module scoring of the top 100 genes. Let me know if you have any issues!

🚨Registrations now live!
Check out this amazing line up of speakers at #RTN #ReThinkNeuroimmunology organised by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Register here: genelayinstitute.org/rtn/

A real privilege to be part of this meeting with so many leaders in the field that I admire. It is an inspiring group of passionate & dedicated physicians/scientists trying to tackle #GBM. Hoping that our collective efforts will lead to effective therapies for these patients. Thanks for the invite!

Thanks @sitcancer.bsky.social!

2. Brain Tumor Immunology Postdoc: Perfect for individuals passionate about developing cutting-edge spatial transcriptomics, multiplex immunofluorescence technologies, & bioinformatics to decode tumor-immune interactions
case.edu/academic-car...
@braintumourcharity.bsky.social
@theabta.bsky.social

1. CAR-T Cell Immunotherapy Postdoc: Ideal for candidates with expertise in CAR-T cell engineering and tumor immunology, eager to translate innovative therapies from the bench to clinical application. case.edu/academic-car...
#immunotherapy #CAR_T
@sitcancer.bsky.social

We have a fun, collaborative group that includes medical and graduate students, staff, residents/fellows, neurosurgeons, neuro-oncologists and neuro-pathologists. Picture from lab holiday party at my house with our close collaborators - Dr. Tiffany Hodges (leader of brain tumor neurosurgery at UH) and Dr. Herb Newton (head of neuro-oncology at UH).

Our lab @caseccc.bsky.social, CWRU SOM, & University Hospitals is recruiting! We are looking for 2 talented immunotherapy postdocs eager to make an impact for brain tumor patients using cutting edge single-cell & spatial genomics & patient-tissue organoids - join us!
Please share positions below:

Honored for our lab to be highlighted in the @caseccc.bsky.social annual report - I can't say enough great things about the environment and support for our new lab. 9 months in and so happy to be @CWRUSOM and @caseccc! A couple pictures in the lab that didn't make the report:

Celebrating two summer fellowships today with ice cream @ Mitchells! Congrats to Kaylie for being awarded the CanSUR fellowship for undergraduates and Medical student Alex Wang the @caseccc.bsky.social Medical Training Award! Both awards will support their work in the lab this summer 🔬

Was great to see friends and colleagues in London as part of the @braintumourcharity.bsky.social annual Scientific Advisory Board meeting! There are exciting things happening in brain tumor research around the world and honored to get to help guide it. Views were pretty good toon

Thanks @lauritzmiarka.bsky.social!

Thanks so much @leilaakkari.bsky.social! Thanks also for providing great feedback as a reviewer - the manuscript improved significantly since the initial submission! Appreciate your time and insights

Thanks so much @sitcancer.bsky.social! SITC was a huge part of my evolution into the immunotherapy space. I took part in #Sparkathon (🙏 @jguerriero.bsky.social), met lots of leaders and peers, have been to the last 4 annual meetings, and was awarded the SITC-BMS fellowship to help support this work!

Thanks Chris!!

Thanks Brian!!

Why brain cancer is often resistant to immunotherapy Researchers find four coordinated gene expression programs in immune cells from glioma tumors, including two that could lead to immunotherapy resistance.

New research uncovers four gene expression “programs” in immune cells that either suppress the immune system or make it more active — and could explain why brain cancer is often resistant to immunotherapy.

@danafarbernews.bsky.social @nature.com

Especially in this uncertain time of federal funding, having support from other sources can be the difference between making discoveries or shutting projects down. If you are interested in supporting our work, we would be grateful for any contribution you can make! Reach out tymillerlab.org

Lastly, research on brain tumors is underfunded & we haven’t had new drug approved for GBM in 2 decades. This work & immunotherapy have a real chance of making meaningful progress but require sustained funding. This foundational work cost >$2M, coming from multiple sources.

A huge thank you to the patients & families that contributed to this study, the orgs that help fund this work - @braintumourcharity.bsky.social , @theabta.bsky.social, @sitcancer.bsky.social, NCI, NIH - & our institutions @dfcicancerbio.bsky.social @broadinstitute.org @mitofficial.bsky.social McGill

Great team effort with Chadi, Charles, Zeyu Chen, Josh D'Antonio,Julia Verga, Martin Villaneuva, Nicolas Gonzalex Casto, Evelyn Tong, Tariq Al Saadi, Andrew Chiocca, @davidsebfischer.bsky.social, @milolab.bsky.social, @jguerriero.bsky.social, Kevin Petrecca, Mario Suva, Alex Shalek, Brad Bernstein!!

3) have created an online tool where you can upload a gene expression matrix of your myeloid cells and it outputs program usages of these consensus programs for all your myeloid cells.
consensus-myeloid-program-calculator.shinyapps.io/shinyapp/

2) deposited all the data and created a portal to explore your favorite genes within these datasets through the @broadinstitute's single cell portal. I suggest using the "Quadrant plot" clustering option
singlecell.broadinstitute.org/single_cell/...