Devon Ryan

PubMed is running on autopilot during shutdown, but key independent committee has been abolished www.bmj.com/content/391/... 🧪

Graduate seminar did a deep dive on Thomas Paine’s Common Sense yesterday. At the line, “in America the law is king,” they (14 students from 6 countries) burst out laughing. I've been doing this for 35 years and this is the first time that was a laugh line.

You know you work for a software company when the description of meeting room names in your new office comes with regex that they will all follow.

Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1...
Read the thread below for a summary of our findings 🧵1/11

New blog post – A quick look at Roche's SBX
lh3.github.io/2025/09/11/a...

Now published in GigaScience with minor improvements: academic.oup.com/gigascience/...

* Download: zenodo.org/records/1490...
* More info: github.com/lh3/panmask

"Did you know the mighty redwood is actually the same species as brocoli and kale ? it's just a different cultivar" "Every year or two, botanists add another plant to Brassica oleracea and see if anyone calls them on it"

Plants phylogeny is a mess anyway

Credit : @xkcd.com

A picture of William Adams, from the TV show Battlestar Galactica, with the quote: "There's a reason you separate military and the police. One fights the enemies of the state, the other serves and protects the people. When the military becomes both, then the enemies of the state tend to become the people."

Always relevant.

My 6th grader is doing a survey for ethics class on the concepts of happiness and luck (or Glück for the German speakers). If you have a few minutes to submit your thoughts she’d appreciate it. docs.google.com/forms/d/1y2b...

Plot of life expectancy after Type 1 diabetes diagnosis, 1850-2025. After the discovery of insulin in 1921, life expectancies go gradually from zero to seventy years.

These are VERY rough estimates, but here's life expectancy after diagnosis of type-I diabetes over the past 150 years.

It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.

I’m overwhelmed by the expressions of sympathy and support.

And still this pales in comparison to what they are doing to immigrants and to undermine the Bill of Rights.

If you could do one thing for me, call your representatives and demand accountability for their white supremacist terrorism.

This seems like a good thing. Are we aloud to have good things? I feel like this is going to turn into a Charlie Brown and Lucy with the football sort of situation.

Were you able to screenshot that? All I see is „blocked“.

Anyone want to go in on an industry collab to fund this?

I've seen enough. Donald Trump is not abiding by a lawful Supreme Court ruling. As a member of Congress, I fully support impeaching him. NOW.

How is this Python package real pypi.org/project/tari...

Cruel Fate, 1525: Our cow died during the night. We will surely perish.

Cruel Fate, 2025: Our Keurig stopped working during the night. We will surely perish.

That’s a wild backdoor…

Burn

I have yet to see a boring thread from you…

Someone needs to do a dramatic reenactment of this

Is this the legal equivalent of questioning a 4 year old that is denying having eaten chocolate while they have chocolate smeared all over their face?

A smiling woman holding a sign for Stand up for Science

#standupforscience #clermont-ferrand

Great, let’s loosen controls on snake oil, just what we need more of.

There are trans Americans right now looking out at this world and wondering if anyone is going to stand up for them and for their simple right to exist.

Well, I am. We are. We will.

How many others had Latin back in the day and read this as SPQR chemistry at first?

Excited to work with Rob's team on extending the salmon/tximeta/Bioc tool chain for long read quantification with oarfish. Lots of interesting challenges but plan to deliver the same high level of provenance detection automatically 🤖

Vcfexpress: flexible, rapid user-expressions to filter and format VCFs AbstractMotivation. Variant Call Format (VCF) files are the standard output format for various software tools that identify genetic variation from DNA sequ

This is very cool work and I'm happy to see it published. Vcfexpress by @brent-p.bsky.social and @aaronquinlan.bsky.social allows building (essentially) arbitrary VCF filters expressed in lua code with parsing & eval powered by rust!

academic.oup.com/bioinformati...

Someone has apparently been fucking with the NIH’s nameservers

/3 Let me repeat that: “I don’t want to talk to you. I want to talk to a lawyer.”

In all other respects, shut the fuck up. Don’t engage them. Don’t let them engage you. They are not trying to help you. They are not trying to “clear this up.” Shut. Your. Fucking. Mouth.