Amber Howell

the climate's probably just changing for attention

Resting-State fMRI and the Risk of Overinterpretation: Noise, Mechanisms, and a Missing Rosetta Stone https://www.biorxiv.org/content/10.1101/2025.09.16.676611v1

Interested in the mechanisms shaping the extraordinary complexity of the connectome?

Then check out our new preprint, lead by
Francis Normand with a stellar team, showing how geometry constrains connectome architecture:

biorxiv.org/content/10.1...

Full thread here:
tinyurl.com/sfv3yf73

I still get chills

Meet Mike
*30+ years severe depression
*first hospitalized @ 13y
*20 meds
*3 rounds of ECT
*2 near-fatal suicide attempts

Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE

see videos, read paper, follow thread
doi.org/10.31234/osf...

The effect of the “exposome” on developmental brain health and cognitive outcomes Neuropsychopharmacology - The effect of the “exposome” on developmental brain health and cognitive outcomes

Absolutely thrilled to share the 🌟 FIRST PAPER 🌟 from ACORN Lab! 🐿️ I’m beyond proud of all-star grad student @heatherarobinson.bsky.social for this review of “exposome” effects on neurodevelopment & cognition! Paper here rdcu.be/ezUqx & thread below 👇 /1

#neuroskyence #PsychSciSky #devsky #cogdev

🚨Preprint!🚨 So excited to share my 1st major study as a postdoc at @holmeslab-bhi.bsky.social!🤘

www.biorxiv.org/content/10.1...

Using a transdiagnostic framework, we found that brain network dynamics were able to discriminate individualized psychiatric symptom profiles with high accuracy 🧵1/9👇

High–resolution laminar recordings reveal structure–function relationships in monkey V1 The relationship between the structural properties of diverse neuronal populations in the monkey primary visual cortex (V1) and their functional visual processing in vivo remains a critical knowledge ...

On behalf of Nicole Carr: new preprint from the Chand/Moore labs! High-resolution laminar recordings reveal structure-function relationships in monkey V1.

1/4

www.biorxiv.org/content/10.1...

Info theory offers powerful measures for capturing complexity & interaction among elements of a complex system, like the brain! 🧠 Here's our new unified reference for key info-theoretic time series measures ft. 📊 visuals, ➗equations, & 💬descriptions:

arxiv.org/abs/2505.13080

🧠💊New preprint differentiating antipsychotic medication vs. illness effects on cortical thickness in people w/ psychosis.

Finding: People receiving placebo show prominent cortical thinning over 1st year of illness, whereas those receiving antipsychotics do not. 1/3

www.medrxiv.org/content/10.1...

Check out our new special issue on cognitive flexibility @coolscontrol.bsky.social: authors.elsevier.com/a/1l4vl8MqMi...

Inferring macroscopic intrinsic neural timescales using optimal control theory The temporal evolution of brain activity relies on complex interactions within and between brain regions that are mediated by neurobiology and connectivity. To understand these interactions, many larg...

🧠 Check out the new preprint from Dr. Linden Parkes, Assistant Professor of Psychiatry at Rutgers Robert Wood Johnson Medical School and Core member of Rutgers Center for Advanced Human Brain Imaging Research (CAHBIR) and BHI! @lindenmp.bsky.social
www.biorxiv.org/content/10.1...

a man applauds with the words so proud of my team above him ALT: a man applauds with the words so proud of my team above him

Excited to share the first major piece of work and preprint from my lab! Led by Jason Kim! 🥳🎉🤘

www.biorxiv.org/content/10.1...

fMRI must break out of its silo We need to develop research programs that link phenomena across levels, from genes and molecules to cells, circuits, networks and behavior.

The scientific community needs to develop processes to support, hire and retain researchers whose work sits between traditional fields of study, writes @avramholmes.bsky.social

#neuroskyence

www.thetransmitter.org/future-of-fm...

fMRI must break out of its silo We need to develop research programs that link phenomena across levels, from genes and molecules to cells, circuits, networks and behavior.

Future of #fMRI:

To make a meaningful contribution to neuroscience, fMRI must break out of its silo

www.thetransmitter.org/future-of-fm...

#neuropsychology #cognition

The molecular and cellular underpinnings of human brain lateralization Hemispheric specialization is a fundamental characteristic of human brain organization, where most individuals exhibit left-hemisphere dominance for language and right-hemisphere dominance for visuosp...

🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization

🔗 doi.org/10.1101/2025...

🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇

#neuroskyence

The molecular and cellular basis of human brain lateralization. Latest paper from @holmeslab-bhi.bsky.social led by @loiclabache.bsky.social. @rutgersbhi.bsky.social, @cahbir.bsky.social

The molecular and cellular underpinnings of human brain lateralization Hemispheric specialization is a fundamental characteristic of human brain organization, where most individuals exhibit left-hemisphere dominance for language and right-hemisphere dominance for visuosp...

Excellent preprint by a great team @loiclabache.bsky.social @sidchop.bsky.social @xi-hanzhang.bsky.social @avramholmes.bsky.social on the underpinnings of human brain lateralization: an Acetylcholine-Norepinephrine axis for functional lateralization + mitochondrial substrates & cellular correlates🧪

"To make a meaningful contribution to #neuroscience, #fMRI must break out of its silo."

My latest attempt to convince you of the importance of multi-scale approaches for the study of the human brain.

fMRI must break out of its silo We need to develop research programs that link phenomena across levels, from genes and molecules to cells, circuits, networks and behavior.

Until recently, in-vivo brain imaging has largely been absent from… integrative efforts, limiting the opportunities to contribute our discoveries, theories or vision toward a comprehensive view of brain function, writes @avramholmes.bsky.social.

#neuroskyence

www.thetransmitter.org/future-of-fm...

fMRI must break out of its silo We need to develop research programs that link phenomena across levels, from genes and molecules to cells, circuits, networks and behavior.

🧠 Featured Insights! Dr. @avramholmes.bsky.social, Associate Prof of Psychiatry at RWJMS and Core Member of BHI & CAHBIR, shares insights on #fMRI and the need for integration across #neuroscience disciplines in @thetransmitter.bsky.social
www.thetransmitter.org/future-of-fm...
#neuroimaging

New paper in Imaging Neuroscience by Vaanathi Sundaresan, Anastasia Yendiki, et al:

Self-supervised segmentation and characterization of fiber bundles in anatomic tracing data

doi.org/10.1162/imag...

Temporal fMRI Dynamics Map Dopamine Physiology Spatial variations in dopamine function are linked to cognition and substance use disorders but are challenging to characterize with current methods. Because dopamine influences blood vessel dilation,...

Interested in dopamine? Have fMRI data? We’ve identified a temporal BOLD feature that carries rich information about dopamine physiology. This measure, obtainable from resting-state and task fMRI, opens new ways to indirectly probe dopamine’s role in cognition and disease. 1/n tinyurl.com/bddyz67b

A network correspondence toolbox for quantitative evaluation of novel neuroimaging results - Nature Communications Here, the authors present the Network Correspondence Toolbox, which enables researchers to examine and report spatial correspondence between their neuroimaging results and widely used brain atlases.

It's finally here! Use the Network Correspondence Toolbox to help contextualize your neuroimaging findings 🧠

👇

Multimodal precision MRI of the individual human brain at ultra-high fields | bioRxiv www.biorxiv.org/content/10.1...

PsyPost covered @lydiaquq.bsky.social's new paper linking internalizing/externalizing symptoms to distinct features! Check it out ⬇️
🖇️https://www.psypost.org/scientists-identify-distinct-brain-patterns-linked-to-mental-health-symptoms

#SciComm #Neuroscience

🚨New lab preprint alert!🚨

Grab a drink, sit down, and let me walk you through the moment-by-moment process of how information loops through basal ganglia circuits during a decision.

(Link at the end of the thread)

1/9

🧩New study: "Network Constraints on 𝘪𝘯 𝘷𝘪𝘷𝘰 Synaptic Alterations in Schizophrenia"

medrxiv.org/content/10.1...

We map a prominent brain-wide pattern of synaptic defects in people with Schizophrenia using PET, then model the molecular, cellular & connectomic features shaping this pattern 🧵1/3👇

Connectivity profile and function of uniquely human cortical areas Determining the brain specializations unique to humans requires directly comparative anatomical information from other primates, especially our closest relatives. Human ( Homo sapiens ) (m/f), chimpan...

Always thought we should use connectivity blueprints to investigate differences between human, chimpanzee, and macaque brains? www.jneurosci.org/content/earl... For Katherine Bryant’s latest masterpiece.

New paper in Imaging Neuroscience by Yaotian Wang, Tingting Zhang, et al:

Analysis of functional connectivity changes from childhood to old age: A study using HCP-D, HCP-YA, and HCP-A datasets

doi.org/10.1162/imag...

Cerebral blood perfusion across biological systems and the human lifespan | doi.org/10.1101/2025...

How does blood perfusion map onto canonical features of brain structure and function? @asafarahani.bsky.social investigates ⤵️