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Dadi Jiang, PhD

@dadijiang.bsky.social

25 Followers  |  53 Following  |  3 Posts  |  Joined: 16.02.2025  |  1.5419

Latest posts by dadijiang.bsky.social on Bluesky

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Acquired resistance in cancer: towards targeted therapeutic strategies - Nature Reviews Cancer Acquired therapeutic resistance is a key contributor to cancer treatment failure, requiring new approaches to address its complex mechanisms. In this Roadmap, Soragni, Knudsen and colleagues discuss t...

πŸŽ‰ The #ARTNet roadmap article is now published in Nature Review Cancer.
Kudos to former Functional Screens & Assays WG chairs Drs. Alice Soragni @alice.soragnilab.com & Erik Knudsen, and all WG members for their valuable contributions! #ARTNetPublication
www.nature.com/articles/s41...

03.06.2025 16:11 β€” πŸ‘ 8    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0

Topics include mechanisms of acquired resistance, modeling approaches to recapitulate the resistance processes, genome-wide screening & spatial and time-resolved technologies and biomarkers as well as lineage-tracing technologies, finally leading to insightful perspectives on clinical translation.

03.06.2025 16:34 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Acquired resistance in cancer: towards targeted therapeutic strategies - Nature Reviews Cancer Acquired therapeutic resistance is a key contributor to cancer treatment failure, requiring new approaches to address its complex mechanisms. In this Roadmap, Soragni, Knudsen and colleagues discuss t...

This is a masterpiece from the @nciartnet.bsky.social on our current understanding and toolbox toward acquired resistance to cancer treatment.

www.nature.com/articles/s41...

03.06.2025 16:33 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance Lei etΒ al. reveal that radiotherapy (RT) elevates mitochondrial copper and induces cuproptosis by upregulating CTR1 and depleting mitochondrial glutathione. Furthermore, BACH1 downregulation confers r...

Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance: Cancer Cell www.cell.com/cancer-cell/...

10.04.2025 20:47 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Agents that cause β€˜copper overload’ can overcome radiotherapy resistance in preclinical models Agents that cause β€˜copper overload’ can overcome radiotherapy resistance in preclinical models

New research found that adding copper-loaded agents to radiotherapy increased intracellular copper levels and induced cuproptosis, overcoming radioresistance.

Why this approach has quick translational potential as a therapeutic strategy: brnw.ch/21wRUPU #EndCancer

10.04.2025 17:39 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Lab dinner to celebrate Ayeisha and Ariana’s acceptance to MSTP and cancer bio PhD program. So proud of these 2 superstars! #endcancer #radonc @mdanderson.bsky.social

08.03.2025 04:06 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

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