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Manu Ben-Johny

@manubenjohny.bsky.social

Ion channels, Ca2+, Biophysics, Engineer, Dad. Assistant Professor at Columbia

96 Followers  |  182 Following  |  2 Posts  |  Joined: 17.11.2024  |  1.449

Latest posts by manubenjohny.bsky.social on Bluesky

Upper - cryo-EM reconstruction of stomatin AQP1 complex. Lower - reconstruction of stomatin-UT-B complex.

Upper - cryo-EM reconstruction of stomatin AQP1 complex. Lower - reconstruction of stomatin-UT-B complex.

Happy to share a new preprint from the Clarke & Vallese (@fravallese.bsky.social) labs reporting #cryoem structures of two RBC stomatin complexes – with AQP1 & UT-B - continuing the SPFH theme from our recent vault preprint! This was a fun one and has been cooking for a while - read on for more! ⬇️

30.08.2025 14:10 β€” πŸ‘ 119    πŸ” 30    πŸ’¬ 8    πŸ“Œ 7

Very excited to share our most recent work on using de novo design to custom engineer a small peptide that can restore proper sodium channel function in disease … to be able to β€œwrite” proteins to do whatever we want them to do, is just remarkable …

20.08.2025 15:09 β€” πŸ‘ 10    πŸ” 9    πŸ’¬ 2    πŸ“Œ 0
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Engineered depalmitoylases enable selective manipulation of protein localization and function - Nature Communications Dynamic palmitoylation modulates protein localization and function. Here, Jayaraman et al develop a toolkit of engineered depalmitoylases to manipulate protein function with spatial, temporal, and substrate specificity.

Very excited to share our latest work on ways to tune S-Palmitoylation of proteins! We engineered Abhd17 enzymes to be chemically/optically activated. We can then use this to inhibit palmitoylation of specific proteins, many possibilities … Check it out!

www.nature.com/articles/s41...

14.04.2025 20:26 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

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