Bradford Taylor

Comparing Strategies to Introduce Two New Antibiotics for Gonorrhea: A Modeling Study Introduction Drug resistance in Neisseria gonorrhoeae is an urgent public health threat. The anticipated approval of two new antimicrobials for gonorrhea prompts the need for evidence-based rollout st...

⚠️ New preprint ⚠️: Two new antibiotics are likely coming for gonorrhea 💊. How should we deploy them in the US to minimize drug resistance? @kroster.bsky.social @dhelekal.bsky.social Eva Rumpler @yhgrad.bsky.social [1/10]
www.medrxiv.org/content/10.1...

THIS. Immigrants are the backbone of US Science. 60% of Postdoc researchers at NIH are Visiting Fellows. Zooming out, 19% of all STEM workers and 43% of doctorate-level scientists and engineers in the US are foreign born.

American science runs on immigrant labor.

🌍Global brains, 🇺🇸American gains🧪

Sang Woo (Daniel) Park and I are excited to share a new preprint, "Susceptible host dynamics explain pathogen resilience to perturbations" [1/8]

www.biorxiv.org/content/10.1...

Generic Indicators for Loss of Resilience Before a Tipping Point Leading to Population Collapse Experiments in yeast confirm that statistical indicators can signal the approach of population crashes.

I was always impressed by how cleanly the empirical results matched dynamical systems theory in this work from Jeff Gore's lab about critical slowing down before population collapse: www.science.org/doi/10.1126/...

Geospatial and demographic patterns of SARS-CoV-2 spread in Massachusetts from over 130,000 genomes Despite intensive study, gaps remain in our understanding of SARS-CoV-2 transmission patterns during the COVID-19 pandemic, in part due to limited contextual metadata accompanying most large genomic s...

I’m thrilled to share our latest preprint! We analyzed >130,000 SARS-CoV-2 genomes from MA to investigate complex transmission dynamics—from statewide patterns, within specific facilities, and at the individual level 🦠🧬

Check out the preprint here ⬇️
www.medrxiv.org/content/10.1...

US map via scienceimpacts.org visualization of economic loss due to IDC cuts to 15% as part of Feb 7, 2025 executive order, with shading denoting intensity of cuts.

Working with an interdisciplinary team, we have developed a website to communicate how the White House's proposed cuts to health research would cause losses of $16B and 68,500 jobs.

Find out how your community may be impacted.

Explore more at SCIMaP: scienceimpacts.org

a 🧵

So glad to share this work by @bradfordptaylor.bsky.social from his time working with us. It's a simple but elegant tweak to some of the established ID epi models. Among other things it helps explain why the great majority of 'variants' did not become dominant
elifesciences.org/reviewed-pre...

How Science Can Adapt to a New Normal Opinion | In the wake of attacks on the research enterprise, scientists need to focus on protecting its fragile infrastructure.

"No one is coming out of the sky to give you your grant money. Your citation portfolio won’t survive this market crash. Your credentials mean nothing. Everything is going to change."

New for @undark.org

undark.org/2025/03/06/o...

@npr.org is contributing to misinformation by not contextualizing Musk’s statements with 1) all feds responded to prior required DOGE emails (existence proof) and 2) that some agencies notified their employees of security dangers in responding to the non-mandatory 5 bullet email

Solid. I now realize I might've just misinterpreted the plot because the blue line does not span the entire domain. Since it met the red perfectly visually I thought it was plotted over at later time points (which in retrospect wouldn't make any sense).

You're creating, and I'm just destroying :-\. Appreciate it all, especially your book

Looks like it's after 365 days too

Seems odd blue and red lines merge. Any sense what's up?

Enterobacteriaceae isolated from patients share antibiotic resistance conferring plasmids recently acquired from those isolated from sinks in the same treatment room Identifying how and where pathogens acquire antibiotic resistance is crucial to developing effective strategies to limit its spread. Many bacterial species carry and share plasmids harboring antibioti...

Not the most visually appealing, but I’ve found dot plots (eg, via mummer/nucmer) adequate

Check out our preprint: www.biorxiv.org/content/10.1...

Caveat, the results in the paper are underpowered because a lack of funding to sequence more. The figures are fine though

26 households too, so that variance is probably up there, but not shown

This is certainly interesting… and in Utah. Shifting demographics between groups likely explains the curious nonlinearity.

Would love an add

I agree feeds would create different attachment dynamics. I also wonder about whether some differences are transient -- currently being driven by founder effects given bsky's nascence

Should I stay or should I go? 🎵

In a new opinion piece, Claudia Igler, Andrina Bernhard and I discuss how conjugative plasmids and temperate bacteriophages balance vertical and horizontal transmission: ecoevorxiv.org/repository/v...

Our framework sheds light on many aspects of MGE biology (1/7)

It's real.

Asymptomatic: The Silent Spread of COVID-19 and the Future of Pandemics

Pre-order in advance of 10/22 release by Johns Hopkins University Press.

bit.ly/asymptomatic...

More soon on events and interactions to come.
.

Let’s me say “motherfucking piece of shit MAGA isn’t working” in a professional context. I like that.

There is now a cover. Asymptomatic is available for pre-order, forthcoming from JHU Press on October 22, 2024.

www.amazon.com/Asymptomatic...

I'm not affiliated, but this is public on the meren lab website: merenlab.org/culture/

Reminds me of two classics: journals.aps.org/prl/abstract...

and:

www.jstor.org/stable/29775...

Cool work from friends & mentors: "we deployed a high-throughput combinatorial screening platform, DropArray, to evaluate the interactions of over 30,000 compounds with up to 22 antibiotics and 6 strains of Gram-negative ESKAPE pathogens, totaling to over 1.3 million unique combinations"

New @biorxiv-microbiol.bsky.social preprint on optimizing experiments to infer multiphasic decay of infectious viruses, led by Jeremy Seurat w/Justin Meyer & team, we leverage synthetic sims to design, implement, & identify a hidden majority of rapidly decaying phage

www.biorxiv.org/content/10.1...

A thread on using 'Quantitative Biosciences: Dynamics Across Cells, Organisms, and Populations' & the computational guides in Python, R or MATLAB in a classroom setting (release 3/5/24 via @princetonupress.bsky.social).

The central point for students: you can do it!

bit.ly/qbios_book

Quantitative Biosciences: Dynamics Across Cells, Organisms and Populations. Released date: March 5, 2024 via Princeton U Press. Companion guides in MATLAB, Python, and R.

After nearly 10 years in development, delighted to share news that 'Quantitative Biosciences: Dynamics across Cells, Organisms, and Populations' is available for pre-order from Princeton University Press:

press.princeton.edu/books/paperb...

Ross McInnes, a post-doc in my group, will sadly be leaving in Spring 2024 as we reach the end of a grant.

He is now looking for a job. Ross is excellent and has a skill set that includes molecular biology, functional and comparative genomics, and microbiome research: rosssmcinnes.github.io

Are you an undergrad and love math modeling (or tolerate it and want to know more)? One week left to apply for the Workshop to Increase Diversity in Mathematical Modeling & Public Health! March 4-5, 2024 in Boston. #episky #idsky
ccdd.hsph.harvard.edu/increase-div...