A chance to join Fenaβs group @fenaochs.bsky.social @cgen2025.bsky.social! Great lab and center - plus you will become our neighbourπ
01.12.2025 13:04 β π 1 π 0 π¬ 0 π 0
Thank you to everyone involved and support from colleagues at @cgen2025.bsky.social and @ucph.bsky.social
07.11.2025 12:17 β π 0 π 0 π¬ 0 π 0
Key takeaways:
π Oxidative damage causes an instant shutdown of transcription, but unlike UV, without RNAPII degradation
π Stalled RNAPII resumes transcription from within the gene body
π PARylation controls early elongation restart
π BER and SSBR repair enable RNAPII recovery in the gene body
07.11.2025 12:16 β π 0 π 0 π¬ 0 π 0
This beautiful work, led by Quentin Thomas, revealed a surprising spatial organization of the transcriptional response:
π¬ Promoter regions: PARylation governs early RNAPII release
π¬ Gene body: DNA damage and repair drive RNAPII stalling
07.11.2025 12:15 β π 0 π 0 π¬ 0 π 0
Oxidative stress triggers RNAPII arrest through PARylation and DNA damage
UV or gamma irradiation, as well as certain chemicals, generate DNA damage that disrupts transcription through a variety of well-characterised mechanisms. In contrast, the transcriptional response to ...
What happens to transcription upon oxidative DNA damage? π§¬π₯
RNAPII halts instantly within genes βοΈ and even more surprisingly: It restarts from where it stopped without leaving the DNA template π¦
ππ How does this happen? Find out in our new preprintπ www.biorxiv.org/cgi/content/...
07.11.2025 12:13 β π 8 π 1 π¬ 3 π 0
Huge thanks to our amazing team and members within @cgen2025.bsky.social for fruitful discussions π
24.10.2025 10:34 β π 1 π 0 π¬ 0 π 0
What did we find? β
Elongation rates vary between genes β
β¦and within genes β
Histone marks & elongation factors correlate with rate subclasses
24.10.2025 10:31 β π 1 π 0 π¬ 0 π 0
Existing methods either rely on indirect estimates or are limited to a handful of long genes. So we built DRB/TTchem-seq2: Short timepoint sampling, new computational framework π leading to a ~7 fold increased individual gene elongation rates measurements!
24.10.2025 10:30 β π 1 π 0 π¬ 0 π 0
Kinetic measurement of gene-specific RNA polymerase II transcription elongation rates
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
Interested in measuring RNAPII elongation rates? We developed DRB/TTchem-seq2 to directly measure rates across 3,000+ genes π§¬
genome.cshlp.org/content/earl...
This fantastic work led by Haiyue Liu reveals gene and intra-genic variation, links to histone marks & elongation factors
Details below! π
24.10.2025 10:25 β π 9 π 2 π¬ 4 π 0
Such a beautiful example of how tight control of transcriptional activity is achieved and even more important: plays a crucial developmental role. Congratulations @jzylicz.bsky.social and team!
18.09.2025 12:47 β π 1 π 0 π¬ 0 π 0
βοΈOne more week to apply for a PhD position in our groupπ
28.02.2025 12:39 β π 2 π 0 π¬ 0 π 0
Gegersen Lab
The aim of the lab is to understand regulation of transcription and co-transcriptional processing in human cells
Another chance to join our group! Center for Gene Expression has 2 or more postdoc positions @ucph.bsky.social in wonderful Copenhagen. Want to join our team to work on transcriptional regulation? More information at: gregersenlab.com Deadline March 18. Apply here: jobportal.ku.dk/phd/?show=16...
21.02.2025 08:56 β π 3 π 3 π¬ 0 π 0
We are recruiting! Center for Gene Expression has 2 or more open positions for PhDs @ucph.bsky.social. Come join our team to work on RNAPII and transcriptional regulation (gregersenlab.com). It's a wonderful city and amazing research environment. Deadline March 6. jobportal.ku.dk/phd/?show=16...
13.02.2025 20:09 β π 6 π 9 π¬ 0 π 1
We're hiring a motivated PhD student! Join reNEW @ucph.bsky.social & @nucleardn.bsky.social to study how metabolism regulates chromatin & stem cell fate thanks to generous Marie SkΕodowska-Curie Fellowship. Remember to apply both at shorturl.at/yf7Qq & nuclear-dn.eu.
07.02.2025 15:20 β π 13 π 12 π¬ 0 π 1
PhD-Beusch_202501_final.pdf
Now official: We have another opening for a fully funded #PhDposition in the Beusch lab (www.beuschlab.org) at @uniwuerzburg.bsky.social! More details here: tinyurl.com/947xcw85 If you or someone you know is curious about #splicing please apply or contact me for more information! #RNAsky #RNAbiology
29.01.2025 08:52 β π 10 π 15 π¬ 0 π 1
Posts from the NovoaLab members @CRG - Epitranscriptomics And RNA Dynamics Lab. #RNAmodifications #nanopore #ribosome #tRNA #translation #specializedribosomes #inheritance #cancer #machinelearning #discover #imagine #funscience
novoalab.com
LEAD Postdoc fellow at the University of Copenhagen | RNA biologist | Mammalian synthetic biologist specialised in CRISPR tool development | Data scientist
Molecular Biologist (aemonten.github.io) δΈ¨Chief Editor @ CSH Protocols (cshprotocols.cshlp.org) δΈ¨Head of the Integrity in Publishing Group at CSHL Press δΈ¨Chair "Molecular Biosystems Conference" (molbiosystems.com) δΈ¨(Oxford) Comma King δΈ¨Central Dogma Police
Group leader at MRC Human Genetics Unit, University of Edinburgh. Interdisciplinary research on disease #epigenetics. Part-time solo dad. Occasional music and climbing.
https://institute-genetics-cancer.ed.ac.uk/research/research-groups-a-z/sproul-group
Computational Biology group located at Universtiy of WΓΌrzburg, Germany. We work on #alternative_splicing #RNAmodifications #RNAtransport #RNAstability #RBPs_in_disease #DNAreplication #DNAfragility
Assistant Prof @ Mount Sinai
β€οΈ RNA, viruses, viral non-coding RNAs β€οΈ
Lab head in stem cell and cancer epigenetics at PeterMac, UniMelb π¦πΊπ§¬
Scientist, mum, dreamer
She/her. Views are my own
www.eckmaslab.com
Institute of Molecular Biology, BAS
#DNArepair #Replication #Genomeintegrity #Cancer #Anticancerdrugs #Microscopy
Lise Meitner Research Group Leader @ Max Planck Institute for Multidisciplinary Sciences
Genome Organisation and Regulation
She/her
Associate Professor at UmeΓ₯ University, RNA biology, RNA modifications, cancer. I love traveling, music and books. Mother of two.
Postdoctoral researcher at @boultonlab @crick.ac.uk interest in ALT, Telomeres, Telomere maintenance mechanisms in cancer ποΈHiking and ποΈNature Lover.
Translational hepatology (liver and bile duct cancer research): Patient characterization and stratification, epi-therapy, immunogenomics, metabolic liver diseases.
We are part of the University of Copenhagen, Biotech Research and Innovation Centre
Postdoc@King's College London, RNA Biology.
PhD@Uni of Birmingham, UK.
MS Molecular Biology & Functional Genomics@Uni of Trieste and ICGEB, IT.
Postdoctoral researcher in the Boulton Lab 𧬠The Francis Crick Institute, London, UKβͺοΈinterest in genome stability, chromatin, cancer 𧫠π©βπ¬ EMBO and MSCA fellow
Researcher @grothlab.bsky.social, Danish cancer institute. Cellular plasticity and cell fate. Genome function. Chromatin biology. Chromatin replication.
Group leader Research Institute of Molecular Pathology (IMP) impvienna.bsky.social in Vienna, trained at MSKCC, working on #cancer #tumorimmunology #resistance. Mentor. Mum. Views are my own.
https://www.obenauflab.com/
https://www.imp.ac.at/
Senior Lecturer in Bioinformatics at the University of Sheffield. Likes gene regulation, 3' UTRs, non-coding RNA and dancing. He/Him/His
Also at IanSudbery@genomic.social
