Adele Marston

Really looking forward to this meeting, still chance to register!

The Discovery Research Platform for Hidden Cell Biology now has a Bluesky account. Follow us here for news and events @drphcb-uoe.bsky.social

Last day for early bird registration!

A special thanks to the fly expert reviewers for helping us clarify a few points, including the late Scott Hawley, whose review was filled with the enthusiasm and generosity we all knew him for.

The functional organisation of the centromere and kinetochore during meiosis Meiosis generates gametes through a specialised cell cycle that reduces the genome by half. Homologous chromosomes are segregated in meiosis I and sis…

@lbkoch9.bsky.social and I wrote a Current Opinion piece highlighting recent progress in our understanding of centromere and kinetochore function in meiosis.
www.sciencedirect.com/science/arti...

Early bird registration is this Friday - don’t miss it!

Hidden cell dark genome 2025 Hidden cell dark genome 2025

📣 One week left for early bird registration and abstract submission for the 'Hidden Cell, Dark Genome' conference 3-4th April in Edinburgh. Regulatory functions of the dark genome, uncharted proteins & RNA complexity, cellular diversity, and atomic structures at the cellular scale 🧬! Join us #HCDG25

Don’t miss the early bird registration for this exciting meeting focused on neglected areas of genetics, cellular and structural biology. Lots of slots for speakers selected from abstracts. 2-4 April 2025 in Edinburgh.

I am very shocked and saddened to hear this news. He made so many important contributions in so many different ways.

📢The 2025 MAYosis webinar series will be held on consecutive Wednesdays, May 7-28, at 4 pm CET (7 am PST; 12 am JST) meiosis.cornell.edu/mayoss2025/ Apply to give a talk (deadline is March 8, trainees and junior faculty only): tinyurl.com/47k3cjpn Registration is free: tinyurl.com/39rs53yv

Molecular mechanism of condensin I activation by KIF4A | The EMBO Journal imageimageHow loss of KIF4A chromokinesin reduces chromosome association of condensin has remained unclear. This study demonstrates that human condensin I is auto-inhibited by short linear motifs (SLi...

See also related work by @eecutts.bsky.social and thanks to Erin and Luis for a great co-submission experience www.embopress.org/doi/full/10....

Molecular mechanism targeting condensin for chromosome condensation | The EMBO Journal imageimageHow the condensin complex is recruited to genomic domains to promote their condensation is incompletely understood. This study identifies a generalised molecular mechanism by which condensin...

Happy to see this out before the end of the year. Fantastic work by Lily Wang with help from our wonderful technologists in the Discovery Platform Proteomics Core managed by Christos Spanos. Great publishing experience @embojournal.bsky.social www.embopress.org/doi/full/10....

On the origin of mitosis-derived human embryo aneuploidy Nature Communications - Chromosome segregation errors are common in the early stages of human embryonic development. By examining the first mitotic divisions of human embryos using live cell...

Chromosome segregation errors are common in the early stages of human embryonic development. Read here our open access commentary on three recent studies of spindle architecture and positioning features that
could provide insights into why early embryos are predisposed to aneuploidy.
rdcu.be/d1TgG

Looking forward to the next cell cycle meeting at the Salk Institute! www.salk.edu/events/scien...

Two fully funded PhD opportunities in our lab. Interdisciplinary, DNA replication, cancer research, structural biology… deadlines in early Jan. Open to international students. t.co/WEJJIU4zU4

www.findaphd.com/phds/project...

Chromosome Segregation and Aneuploidy Aneuploidy is a hallmark of cancer and developmental disorders such as Down syndrome. Understanding how cells accomplish faithful chromosome segregation and how chromosomal instability (CIN) impacts …

Announcing the next EMBO Chromosome Segregation and Aneuploidy Meeting! Italy 2025. Please register and join us for another exciting and friendly meeting in a beautiful location meetings.embo.org/event/25-ane...

Great line up for EMBO meiosis 2025!

#Meiosis4eva starter pack. I am sure I missed many so please self nominate by commenting or just DMing me go.bsky.app/P3BJYze

Want to know how the abundance or phosphorylation of your favourite budding yeast protein changes during meiosis? Check out our new searchable online tool created by the talented Lori Koch meiphosprot.bio.ed.ac.uk. Also check out the preprint www.biorxiv.org/content/10.1... coming to @emboj soon!

9 days left to register for the Cell Cycle meeting in Roscoff. Register and abstract submission here: www.insb.cnrs.fr/fr/cycling-d...

A new preprint from our group in collaboration with @jvhooff.bsky.social and @eelcotromer.bsky.social. We discovered that trypanosomes have (a zombie of) Bub1-Bub3 despite the fact that tryps do not have a canonical spindle checkpoint! This is a team work involving Dan, WillC, Midori and Patryk

Overall we show that Mad3 acts outside of its checkpoint role to actively direct chromosome segregation.

We found that Mad3 binds the Stu1 (CLASP) microtubule regulator through its degenerate TOGL1 domain. We showed that Mad3-Stu1 association rescues the segregation of chromosomes that lack crossovers or fail to biorient in meiosis I.

We discovered that in addition to its well known role in delaying the cell cycle as part of the spindle checkpoint, Mad3, has a separate role in promoting chromosome alignment on the spindle in budding yeast meiosis.

Check out our new preprint. Great PhD work of Anu Mukherjee with expert mass spec from Christos Spanos. Checkpoint-independent association of Mad3BUBR1 with Stu1CLASP directs homolog alignment in meiosis I www.biorxiv.org/content/10.1...

Thanks! Indeed! 🎄

First post for our first human oocyte paper, finally published today! Congratulations to all authors, especially Bettina Mihalas who bravely traveled across the world to join a yeast lab and start a human oocyte project. Forever grateful! www.sciencedirect.com/science/arti...