Simon Bullock

A beautiful model of an mRNA transport complex that looks like a Texas congressional district

Sometimes, knocking out a gene isn't a good way to figure out the function of that gene ...

In our new @jcellsci.bsky.social paper, we report potent transcriptional adaptation by cytotoxic T lymphocytes (CTLs) in response to CRISPR/Cas9-mediated deletion of the important polarity protein CDC42 🧵⬇️

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...

Our latest work, in collaboration with the terrific @kashishsingh.bsky.social in the Carter lab @mrclmb.bsky.social is out. So proud of this study and everyone involved...

In-cell structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cells In eukaryotic cells, LINC complexes physically bridge the two nuclear membranes to cytoskeletal filaments, transmitting mechanical forces to the nucleus. Due to their dynamic and membrane-embedded nat...

Fantastic work by the group of @matteoall.bsky.social : a SUN5:Nesprin3 complex at the head:tail junction of sperm cells. 🤯 #teamtomo

www.biorxiv.org/content/10.1...

Our new work on the establishment of quiescence in #adultneurogenesis , done at @institutocajal.bsky.social @csic.es, is out in @plosbiology.org .
Proud of a Great team, Cristina Medina,
@paulatiradom.bsky.social , Lingling Li , @pilar-rguezm.bsky.social and the rest ! 🎊🎉🧠

Research Group Leader in Chemical/Synthetic Biology at MRC Laboratory of Molecular Biology Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...

We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).

Multi-scale Molecular Imaging of Human Cells reveals COPI and COPII Vesicles at ER Exit Sites Trafficking from the endoplasmic reticulum to the Golgi apparatus comprises the first steps toward the correct localization of 30% of eukaryotic proteins. Coat protein complexes COPII and COPI are inv...

Go check out the latest preprint from Giulia Zanetti's lab. @dr-downes.bsky.social used cryo-tomography to directly visualize COPI and COPII coated vesicles in situ at unprecedented resolution in human cells. Amazingly beautiful, rigorous, insightful work.
www.biorxiv.org/content/10.1...

Escherichia coli with a 57-codon genetic code The near-universal genetic code uses 64 codons to encode the 20 canonical amino acids and protein synthesis. Here we designed and generated Escherichia coli with a 4 Mb synthetic genome in which we re...

Escherichia coli with a 57-codon genetic code | Science www.science.org/doi/10.1126/...

In 2025, the Brennecke lab revealed how ancient endogenous retrotransposons diversified like Darwin’s finches, each adapting to a specific cell type within the Drosophila ovary. Read more about the Brennecke Lab’s research: imba.science/BrenneckeLab

Fly folks - want to do RNAi in embryos to look at patterning. Haven't delved into this before - any suggestions of good Gal4 drivers? #Drosophila

mRNA trafficking directs cell-size-scaling of mitochondria distribution and function - Nature Communications How mitochondria positioning dynamically adapts to changes in cell shape is poorly understood. Here, Bradbury et al. show that cell-size-dependent trafficking of TRAK2 mRNA underpins the cell-size-sca...

If you’ve ever wondered how cells tune positioning of organelles in response to cell shape change, and what happens when this goes wrong, please check out our new manuscript – mRNA trafficking controls cell-size-scaled organelle dynamics! www.nature.com/articles/s41...

The image features a message from Richard Hodge, a cancer editor at PLOS Biology, inviting submissions of primary research papers that offer novel insights into tumor progression and therapeutic contexts, displayed alongside the PLOS Biology logo and a photograph of Richard Hodge.

In this new #Biologue post, we speak to Richard Hodge, a cancer editor at #PLOSBiology about the new Collection “Unveiling cancer crosstalk across spatial and temporal scales”, his background in #CancerResearch and his vision for #cancer biology at the journal 🧪
plos.io/3U6GXFW

The Dunn School is a really great environment for taking up a Career Development Fellowship, and we are looking for candidates! Please spread the word.

Our lab is looking to recruit a new postdoc to join our team. You can visit us at leritlab.org to learn more and submit applications here: faculty-emory.icims.com/jobs/149999/... (or scan the QR in the ad below!) Review will commence in early August.

Postdoc in Structural Biology of RNA processing complexes Postdoctoral positions in structural biology of macromolecular complexes are available in the laboratory of Dr. Eva Kowalinski at the EMBL Grenoble, France. We are looking for highly motivated and amb...

Postdoc positions in structural biology of RNA processing complexes.

An ERC-funded position will dissect pre-mRNA processing pathways in the infective organism Trypanosoma brucei. An ANR-funded position will characterise large complexes in RNA modification.

Details: tinyurl.com/postdoc-RNA-...

Pls. share widely

Calling all transposon fans & lovers of genetic innovation

MOBILE GENOME welcomes you in Heidelberg, Nov. 4–7 2025

→ Vibrant & friendly community
→ Cutting-edge talks from mechanisms to physiology
→ Plenty of surprises (TEs never stop innovating)

submit abstract by July 29

The important characterisation of the UK pop'n from More In Common highlights v low levels of trust in most former 'authoritative' professions.

Scientists are the exception.

Trust both fragile & valuable. We scientists must continue to *earn* it. Science communication is more important than ever.

MRC Postdoctoral Research Scientists x 5 - MRC Laboratory of Medical Sciences Applications are now open for up to five postdoctoral positions in the area of developmental epigenetics.

Interested in developmental epigenetics? So are we! Apply now to join us for your postdoc!

Multiple positions across multiple groups @mrc-lms.bsky.social

Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇

lms.mrc.ac.uk/work/vacanci...

We will start reviewing applications for this research technician position next week. If you’re thinking of applying, I encourage you to submit this week.

I am awaiting SOM approval for a postdoc hire and hope to advertise that position soon - stay tuned!

Sjors Scheres

Excellent opportunity for a postdoc to join @sjorsscheres.bsky.social in the LMB’s Structural Studies Division to work on #cryoEM structure determination of amyloid filaments in a lively, multi-disciplinary group.
Read more: www.nature.com/naturecareer...
Closes 03 AUG
#PostdocJobs #ScienceJobs

It’s too late on a Friday night for me to post sensibly about this work! But I’m super proud of Joanna’s determination to validate Parkin substrates and I love working with her robust and creative science!

This is a very exciting opportunity! 👇

Postdoctoral Scientist - Structural Studies - Dr Joe Greener - LMB 2633 - Cambridgeshire job with MRC Laboratory of Molecular Biology (LMB) | 12840475 Postdoctoral Scientist Salary £41,344 per annum  Fixed Term – 3 years MRC Laboratory of Molecular Biology, Cambridge, UK We are looking for a postd...

Interested in a postdoc position combining computational protein design and molecular simulation? There is an open position in my group at the MRC-LMB in Cambridge, UK.

www.nature.com/naturecareer...

Feel free to message me with any questions.

👋 Are you looking for a postdoc position? Do you think microtubules are fascinating? Then we might have the job for you! 2-year funded postdoc to join our lab!
👉 deadline 20/06
👇 check it out

www.godinholab.com

We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.

Temporal and spatial coordination of DNA segregation and cell division in an archaeon. Cells must coordinate DNA segregation with cytokinesis to ensure that each daughter cell inherits a complete genome. Here, we explore how DNA segregation and division are mechanistically coupled in ar...

We are excited to share our preprint describing how Sulfolobus cells coordinate DNA segregation with cell division! In eukaryotes this type of regulation involves checkpoints and CDK-cyclins. But how does this work in archaea? This is the question we ask in our paper: www.biorxiv.org/content/10.1...

⏰ Deadline approaching for postdoc position in my lab, Dunn School, University of Oxford.

We work on how the cell's antenna receives and transmits essential signals through motor protein driven transport.

❄️ Cryo-EM/ET, smTIRF, cell biology methods 🧪🔬

30/5/25 ➡️ tinyurl.com/KToropovaPDRA

Optical Pooled Screening has transformed large-scale cell biology, but lacks robust end-to-end computational strategies to process these Tb-sized datasets. New from Di Bernardo et al (@mat10d.bsky.social‬):

Brieflow. A game changer for OPS + new biological insights

www.biorxiv.org/content/10.1...

Cover image for the journal Traffic (July 2018) featuring an image captured by Dr. Pearl Ryder of mitotic spindles (green microtubules), condensed chromosomes (blue), and single molecule fluorescence in situ hybridization (smFISH) for Centrocortin mRNA (magenta)

Our protocol describing how we detect beautiful microtubules (and actin) in Drosophila embryos is now up at Current Protocols. We also added tips if you also want to image RNA via smFISH (see pic). If your institution does not subscribe, here's a free link: onlinelibrary.wiley.com/share/author...