Jelle van den Ameele's Avatar

Jelle van den Ameele

@jellevda.bsky.social

230 Followers  |  58 Following  |  1 Posts  |  Joined: 04.01.2025  |  1.7812

Latest posts by jellevda.bsky.social on Bluesky

Senior Research Associate (Fixed Term) Nuclear-mitochondrial genetic interactions in health and neurodegenerative diseases Fixed-term: The funds for this post are available until 30 September 2028 in the first instance. The University of

πŸ“’ We are hiring a Senior Research Associate in Bioinformatics & Statistical genetics @cam.ac.uk @mrc-mbu.bsky.social @camneurodept.bsky.social @jellevda.bsky.social It's a great time to join this dynamic and world leading team working on #mitochondria Closes 28/8/25

www.cam.ac.uk/jobs/senior-...

01.08.2025 13:50 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Welcome to the new serie of Cambridge Fly Club meetings. We organise several events every year to foster collaboration and maintain a positive dynamic between Drosophila groups in Cambridge.

23.05.2025 14:43 β€” πŸ‘ 7    πŸ” 3    πŸ’¬ 1    πŸ“Œ 1
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Thanks to @lilyfoundation.bsky.social for taking these snaps of the centre leads and team members! Together we hope to do great things over the next 5 years of the LifeArc Centre! #mito @ucl-qs-cnmd.bsky.social @taylorlabncl.bsky.social @ritahorvath.bsky.social @jellevda.bsky.social

08.05.2025 16:42 β€” πŸ‘ 6    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Plaque showing that we are proudly part of the LifeArc Centre for Rare Mitochondrial Diseases, with funding from MDUK

Plaque showing that we are proudly part of the LifeArc Centre for Rare Mitochondrial Diseases, with funding from MDUK

We spent a great afternoon at the House of Lords for the launch of the @lifearc.bsky.social Centre for #Rare #Mitochondrial Diseases, supported by @mdukcharity.bsky.social The event centre hosted staff, dignitaries, patients, MPs & those involved in rare disease policy & research. We even unveiled…

07.05.2025 20:13 β€” πŸ‘ 8    πŸ” 3    πŸ’¬ 2    πŸ“Œ 0

It was a great day and a fantastic #PPIE workshop!! @lifearc.bsky.social @ritahorvath.bsky.social @jellevda.bsky.social @robpitceathly.bsky.social @taylorlabncl.bsky.social @dwong47.bsky.social @mitogene.bsky.social @mrc-mbu.bsky.social @mitonewcastle.bsky.social @uclqsion.bsky.social

15.04.2025 18:36 β€” πŸ‘ 9    πŸ” 2    πŸ’¬ 0    πŸ“Œ 1
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🚨 Join us for the @faseborg.bsky.social
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. πŸ“… Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!

12.04.2025 13:42 β€” πŸ‘ 15    πŸ” 15    πŸ’¬ 0    πŸ“Œ 0

2x CRA posts extended until end of April. So you have another chance to work with #mito disease patients as part of the @lifearc.bsky.social centre for #rare #mito diseases! See links below to apply!
@eastgenomics.bsky.social @camneuro.bsky.social @cuhnhs.bsky.social

11.04.2025 06:23 β€” πŸ‘ 6    πŸ” 3    πŸ’¬ 0    πŸ“Œ 1
Data collected with the new sequencing platform HyDrop v2 is shown. First, a schematic overview of the bead batches of the microfluidic beads is followed by a tSNE and a barplot showing the costs in comparison to 10x Genomics. 
Then, a track of mouse data (cortex) is shown together with nucleotide contribution scores in the FIRE enhancer in microglia. Here, the HyDrop and 10x based models show the same contributions. 
On the right, the Drosophila embryo collection is explained; in the paper HyDrop v2 and 10x data are compared to sciATAC data. Then, a nucleotide contribution score is also shown, whereas HyDrop v2 and 10x models show the same contribution, just as in mouse.

Data collected with the new sequencing platform HyDrop v2 is shown. First, a schematic overview of the bead batches of the microfluidic beads is followed by a tSNE and a barplot showing the costs in comparison to 10x Genomics. Then, a track of mouse data (cortex) is shown together with nucleotide contribution scores in the FIRE enhancer in microglia. Here, the HyDrop and 10x based models show the same contributions. On the right, the Drosophila embryo collection is explained; in the paper HyDrop v2 and 10x data are compared to sciATAC data. Then, a nucleotide contribution score is also shown, whereas HyDrop v2 and 10x models show the same contribution, just as in mouse.

Our new preprint is out! We optimized our open-source platform, HyDrop (v2), for scATAC sequencing and generated new atlases for the mouse cortex and Drosophila embryo with 607k cells. Now, we can train sequence-to-function models on data generated with HyDrop v2!
www.biorxiv.org/content/10.1...

04.04.2025 08:52 β€” πŸ‘ 54    πŸ” 25    πŸ’¬ 2    πŸ“Œ 2
Bioinformatician - disease gene discovery - inherited mitochondrial diseases (Fixed Term) - Job Opportunities - University of Cambridge Bioinformatician - disease gene discovery - inherited mitochondrial diseases (Fixed Term) in the Division of Neurology at the University of Cambridge.

We are hiring #bioinformaticians. One post to work on the new @lifearc.bsky.social centre for rare #mitochondrial diseases, and one is a joint project @mrc-mbu.bsky.social with Prof Patrick Chinnery & @mitogene.bsky.social
Apply here:
www.jobs.cam.ac.uk/job/50861/
www.jobs.cam.ac.uk/job/50860/

02.04.2025 13:52 β€” πŸ‘ 5    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0
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Exited to share our latest preprint! mRNA-LNPs are efficiently delivered to healthy livers, but what about liver tumours? Our postdoc @laura-leighton.bsky.social found liver tumours efficiently take up mRNA, enabling next generation mRNA-LNP cancer therapeutics.

www.biorxiv.org/content/10.1...

20.03.2025 04:38 β€” πŸ‘ 8    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Description of 3 job advertisements and the MitoCAMB team

Description of 3 job advertisements and the MitoCAMB team

All the jobs, all in one place!!

28.02.2025 14:42 β€” πŸ‘ 4    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
QR code for 3 jobs

QR code for 3 jobs

πŸ“’ We have not 1 but 3 clinical/patient-facing jobs working with #mitoCAMB on the #LifeArc #raredisease centre for #mito diseases.

1x pre/post-doctoral CRA;
1x post-doctoral CRA (with potential to become a 4 year ACL); 1x research coordinator

Join us! Links below.

28.02.2025 10:56 β€” πŸ‘ 7    πŸ” 9    πŸ’¬ 5    πŸ“Œ 1
LinkedIn This link will take you to a page that’s not on LinkedIn

We are hiring.🚨 The Tissue Gene Regulation Lab is looking for an experimental PhD student or PostDoc to join our efforts in devising new single cell methods and decoding gene regulation. πŸ’»πŸ”¬πŸ§«
Come join me and my lab in beautiful Copenhagen. πŸ‡©πŸ‡°

PhD - lnkd.in/dtKz_gnA
PostDoc - lnkd.in/dBgn6AcK

26.02.2025 10:37 β€” πŸ‘ 6    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0
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Brain drug cure needed for future 'trapped in' generations Scientists hope to find a cure for a genetic condition linked back to a single Cumbrian family line.

BBC news article about one of our patients with #neuroferritinopathy on the DefINe clinical trial, funded by #LifeArc. Spread the word about this disease, and also this trial - more participants needed!

www.bbc.com/news/article...

@ritahorvath.bsky.social @jellevda.bsky.social

11.02.2025 10:08 β€” πŸ‘ 4    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
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LifeArc on LinkedIn: Rare disease research faces unique challenges including lack of… Rare disease research faces unique challenges including lack of investment, small patient populations, fragmented research and challenging routes to…

Very excited to share this #LifeArc video about the 4 new #rare disease centres across the UK, with our centre for #mitochondrial diseases being one of them!

@jellevda.bsky.social @ritahorvath.bsky.social @frisophagy.bsky.social @mrc-mbu.bsky.social

www.linkedin.com/posts/lifear...

29.01.2025 10:54 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 1

Congratulations Meghana, Marco and Eva! Great to have played a small part in this beautiful work!

27.01.2025 19:38 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 1
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H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development In the life of a vertebrate embryo, gene expression is initiated for the first time at zygotic genome activation (ZGA). Maternally expressed transcription factors present in the embryo are essential f...

✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window β€” crucial for proper zygotic genome activation and development. 🐸🧬✨

πŸ“„ Check it out here:
doi.org/10.1101/2025...

πŸ‘‡ Highlights below

22.01.2025 13:56 β€” πŸ‘ 48    πŸ” 20    πŸ’¬ 1    πŸ“Œ 4
Research Coordinator (Fixed Term) - Job Opportunities - University of Cambridge Research Coordinator (Fixed Term) in the Division of Neurology at the University of Cambridge.

Final week to apply for this research coordinator position, working on all things #mito & the LifeArc centre for rare diseases. Join us! www.jobs.cam.ac.uk/job/48491/
@ritahorvath.bsky.social @jellevda.bsky.social

18.01.2025 10:45 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Research Zone - The Lily Foundation Your hub for the latest news, views and breakthroughs in mitochondrial disease research. categories: Research on the road,Researcher spotlight,PPIE round-up,Science unwrapped,Journal club,Trials hub

For any patients (or researchers) interested in #mito research, the Lily Foundation has launched its new 'research zone': www.thelilyfoundation.org.uk/affected-by-...

@ritahorvath.bsky.social @jellevda.bsky.social

09.01.2025 08:57 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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MitoCAMB - Cambridge Clinical Mitochondrial Research Group Studying the genetic basis and mechanisms of mitochondrial diseases. Our aim is to provide a precise diagnosis and to discover new treatments.

New year, new bluesky account, and new website: mitocamb.medschl.cam.ac.uk

03.01.2025 16:32 β€” πŸ‘ 4    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

@jellevda is following 20 prominent accounts