Michelle Vincendeau

An ancient anthozoan protein reveals an alternative evolutionary path of antiviral signaling How antiviral immunity first arose in animals is a central question in evolutionary biology. Using the sea anemone Nematostella vectensis, we identify CARDIB, a previously uncharacterized gene located...

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🚨🚨 preprint alert! 🚨🚨
I wish to introduce CARDIB, not the singer, but the protein.
CARDIB=CARD Inhibitory Binding protein.
In our new work we discover this antiviral protein that is found in all Anthozoa (sea anemones and corals 🪸) but not in other animals.
www.biorxiv.org/content/10.1...

#TEsky Draft Genome Assembly of Parnassius epaphus Provides New Insights into Transposable Elements That Drive Genome Expansion in Alpine Parnassius butterflies doi.org/10.3390/d171...

Join us tomorrow for a Night Science Seminar Series presentation! Jennifer Oyler-Yaniv from Harvard will talk about how a scientific journey can be viewed as a mythological Hero's Quest by sharing work from her lab on how epithelial tissues restrict the spread of viruses.
cassyni.com/events/ZYQow...

A specialized bacterial group II intron is a highly efficient retrotransposon - Mobile DNA Mobile group II introns are site-specific retrotransposons composed of a large self-splicing ribozyme and an intron-encoded reverse transcriptase that are widespread in bacterial and organellar genome...

#TEsky #RNAsky A specialized bacterial group II intron is a highly efficient retrotransposon doi.org/10.1186/s131...

Spatial dynamics of brain development and neuroinflammation - Nature A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.

Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com

www.nature.com/articles/s41...

GitHub - vibhachand/slim-TE-demography-simulation-project Contribute to vibhachand/slim-TE-demography-simulation-project development by creating an account on GitHub.

Writing a letter for a great undergrad researcher in the lab. Check out their awesome GitHub repo on the transposable element simulations they wrote in slim! github.com/vibhachand/s...

Chimpanzees rationally revise their beliefs The selective revision of beliefs in light of new evidence has been considered one of the hallmarks of human-level rationality. However, tests of this ability in other species are lacking. We examined...

Even chimpanzees think rationally and weigh the evidence when making a choice ;-)
@science.org
www.science.org/doi/10.1126/...

Do duplication-inducing elements ‘cooperate’ with genes in evolutionary arms races? A case study on cereal crop pathogenesis - BMC Plant Biology Crop improvement depends on the human ability to harness naturally- or artificially-occurring gene variants. Genomic segmental duplication can create redundant gene copies that can more freely ‘explor...

#TEsky Do duplication-inducing elements ‘cooperate’ with genes in evolutionary arms races? A case study on cereal crop pathogenesis doi.org/10.1186/s128...

Only 6 days left to apply! We’re recruiting a PhD student to study the immunogenic roles of transposable elements in pediatric AML. The project involves working with clinical trial samples in collaboration with Dr. Richard Dillon (KCL). If interested, get in touch!

Job posting. We look for a Full Professor (W3) of Stress Resilience of Plants at the RWTH Aachen.

We are looking for a colleague to join us at RWTH Aachen University:

🌱 Full Professor in Stress Resilience of Plants (W3 tenured)

📌What are we looking for? Someone working with us strategically at the interface of plant biology/ physiology/ resilience

#academicjobs #facultyjobs #PlantJobs

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[2026] – Endogenous retroviruses in human embryogenesis

My lab is seeking two PhD candidates to investigate the function and regulation of endogenous retroviruses in the early stages of human development 🦠👩‍🔬. Apply through the International Max Planck Research School (IMPRS) program: www.molgen.mpg.de/IMPRS/applic.... www.molgen.mpg.de/5094682/Fuey...

For obvious reasons, I've become fascinated with retrotransposons. So we ( @alexwhiteley.bsky.social and I) wrote an article now out in Neuron @cellpress.bsky.social on how we think retrotransposons influence brain function and health! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

Early career group leaders We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

The @crick.ac.uk is recruiting Early Career Group Leaders

- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology

Deadline 27 Nov

www.crick.ac.uk/careers-stud...

Ready to start your own independent research programme?

We're inviting applications for early career group leaders in all areas of biology and biomedicine @crick.ac.uk

Apply by 27 Nov 2025:
www.crick.ac.uk/careers-stud...

#EarlyCareerResearchers #GroupLeader #ScienceCareers

🚀 We’re growing! Are you passionate about human pluripotent stem cells? We are looking for 1 PhD student + 1 Lab technician to join us ☀️

ior.usi.ch/institute/jobs

Interested in learning how to be a good speaker and give effective talks? Season 2 of the NYC Postdoc Night Science Club begins October 15th. Join us NYC Postdocs for a 2hr workshop and maybe also a drink at a bar! Free registration (usually ~100 come): docs.google.com/forms/d/1dII...

AussiERV 2025 AussiERV: Australia’s first symposium dedicated to endogenous retroviruses. Join us for this one-day virtual event on November 7th!

Do you research endogenous retroviruses (ERVs) or want to learn more about them? 🧬🤔

Consider presenting at or attending AuusiERV - an inaugural online symposium for ERV research in Australia 🇦🇺 (and abroad) 🗺️

Abstracts due 1st October!

events.humanitix.com/aussierv-2025

#ERV #retrovirus

Graphic with a blue background and light green dots. The text 'call for applications' appears in green, and 'Ausschreibung' in white. A white arrow on the right points diagonally upward.

Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...

Deep Intronic SVA_E Insertion Identified as the Most Common Pathogenic Variant Associated With Canavan Disease | Neurology Genetics Background and ObjectivesCanavan disease (CD) is a neurodegenerative disorder in which biallelic pathogenic variants in ASPA result in spongiform degeneration of the cerebral white matter, leading to ...

Another neurodegenerative disease caused by an SVA insertion. Not intron retention as seen in XPD, but aberrant splicing.

Dual transposon sequencing profiles the genetic interaction landscape in bacteria Gene redundancy complicates systematic characterization of gene function as single-gene deletions may not produce discernible phenotypes. We report dual transposon sequencing (dual Tn-seq), a platform...

Dual transposon sequencing profiles the genetic interaction landscape in bacteria | Science www.science.org/doi/10.1126/...

Our study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org!
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....

📣 Our department is hiring an Assistant Professor in Evolutionary Cell and Molecular Biology to join the @weillinstitute.bsky.social PLS spread the word!
academicjobsonline.org/ajo/jobs/30607

Frontiers | HERV-K10 as a mediator of immune modulation in hepatitis infections The human genome contains ~8% of endogenous retroviruses (HERVs), whose reactivation has been implicated in diseases such as cancer and autoimmune disorders....

My first postdoc paper in @m-vincendeau.bsky.social lab is out in Frontiers in Immunology.🥳

We identified that hepatitis viruses, especially HBV, upregulate specific human endogenous retrovirus (HERV) groups that are linked with autoimmune diseases.

doi.org/10.3389/fimm...

Check out our new paper 🎉. Thanks to everyone who was involved 🙏🏻.

My first first-author paper is out!🎉
Here we propose a model where a silencing complex, PIWI*, assembles on target RNAs to recruit effectors and shut down transposon activity.
Huge thanks to the Brennecke and Plaschka labs, especially Julius and Clemens, and all co-authors!

Call for a tenure-track position at our Department of Plant Molecular Biology in Lausanne! We are searching for promising early-career researchers in the broad field of plant-organismal interactions. Deadline: November 30, 2025 - Please re-post!

career5.successfactors.eu/career?caree...

Hi! We are looking for a PhD to work on the cross talk between transposable elements, insects and intracellular bacteria on the bioinformatics side. The PhD would be supervised by @mariefablet.bsky.social and myself along with @nicolasparisot.bsky.social Deadline December 2025! Please share! #tesky

Tenure-track faculty search of the UCSF Biochemistry & Biophysics Department is open for applications!

We are looking for creative, innovative scientists asking fundamental questions in any area of biology.

Join our vibrant, collaborative, and supportive community!

aprecruit.ucsf.edu/JPF05702