Jean-Ehrland RICCI

Check how Kindlin-1 loss in SCC can promote invasion through the upregulation of MMP13 and how this leads to the development of a hypoxic environment that is permissive for tumor growth.

“Involvement of Kindlin-1 in cutaneous squamous cell carcinoma”

🔷 Interesting research led by Valerie G. Brunton has been featured in #Oncogenesis.

▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how the authors elucidate the interplay between SLC7A5, mTOR signalling, and autophagy pathways, providing insights into potential strategies to overcome drug resistance in BPA-BNCT therapy.

“Targeting SLC7A5 in lung SC carcinoma: implications for cancer metabolism shift and boron neutron capture therapy resistance”

🔷 High-impact research led by Min-Yuan Chou & Yu-Ting Chou has been featured in #Oncogenesis.

▶️ Read the full open access article here: www.nature.com/articles/s41...

Check why platelet-derived exosomes play an important role in enhancing MM proliferation and how blocking LRG1 is a promising therapeutic strategy for the treatment of MM.

“Activated platelet-derived exosomal LRG1 promotes multiple myeloma cell growth”

🔵 Yanwei Luo’s groundbreaking research appeared in #Oncogenesis

▶️ Read the full open access article here: www.nature.com/articles/s41...

Early methionine availability attenuates T cell exhaustion - Nature Immunology The tumor environment is nutrient deficient. Here the authors show that early availability of methionine is critical for optimal T cell activation and prevents T cell dysfunction, and that dietary met...

www.nature.com/articles/s41...

Check how the authors point to a novel combination therapy that can be further exploited in the treatment of adenomas and CRC.

Check how the authors identified a novel synergistic relationship with berzosertib, olaparib, and talazoparib in combination with first line MIBC therapy cisplatin.

“STAG2 expression imparts distinct therapeutic vulnerabilities in muscle-invasive bladder cancer cells”

🔷 High-impact research led by Anna Woloszynska has been featured in #Oncogenesis.

▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how the authors discovered that EZH2 regulates HMGCS2, one of the rate-limiting steps of ketone metabolism enzymes, and how combining a ketone drink with FDA-approved drugs enzalutamide and Tazemetostat further suppresses tumor progression.

“Ketone drink enhances therapeutic efficacy in prostate cancer by targeting EZH2”

🔵‪Rendong Yang (@yang-lab.bsky.social)‬ & Qi Cao's latest research is now featured in #Oncogenesis!

▶️Read the full open access article here: www.nature.com/articles/s41...

Check how the authors explored the importance of PSPH genetic alterations in glioblastoma in promoting tumor aggressiveness and immunosuppression, which could be effectively targeted by a novel combinatorial therapeutic strategy of sertraline plus chloroquine.

🔵 Dong-Joo Cheon latest research is now available to read in #Oncogenesis

“Lipid droplet-associated hydrolase (LDAH) knockdown enhances TAG hydrolysis and promotes ovarian cancer progression and chemoresistance”

▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how this study shows the relevance of lipid metabolism to the progression and chemoresistance of ovarian cancer and the potential of targeting lipid droplets metabolic steps to mitigate the progression of the disease.

Check the CLiPS-based approach the authors used to identify protease substrates with high selectivity and sensitivity for Pancreatic Ductal Adenocarcinoma (PDAC) that could be employed in protease-dependent targeted strategies to minimize off-target toxicities.

Groundbreaking research led by C. Arnold Spek has been featured in #Oncogenesis.

“Identification of pancreatic cancer-specific protease substrates for protease-dependent targeted delivery”

Read the full open access article here: www.nature.com/articles/s41...

Check how CD147-high EVs impair endothelial barriers in gastric cancer and why they could be a potential diagnostic and prognostic biomarkers.

Discover Min Li's newest findings, now featured in #Oncogenesis

“CD147-high extracellular vesicles promote gastric cancer metastasis via VEGF/AKT/eNOS and AKT/mTOR pathways”

Read the full open access article here: www.nature.com/articles/s41...

Check why the authors concluded that the intrinsically disordered domain of cyclin D1 may provide a rationale new target to complement CDK-extinction strategies.

Richard G. Pestell’s impactful study has been published in #Oncogenesis

“A cyclin D1 intrinsically disordered domain accesses modified histone motifs to govern gene transcription”

▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how NUCKS1 and HDAC2 may serve as biomarkers for the early detection of colorectal cancer (CRC) metastasis, and how they could be leveraged as potential therapeutic targets.

🔵 Jun Chen & Yang Song latest research is now available to read in #Oncogenesis

“NUCKS1 promotes invasion and metastasis of colorectal cancer by stabilizing HDAC2 and activating AKT”

▶️ Read the full open access article here: www.nature.com/articles/s41...

Fumarate hits the brakes on mitophagy In this issue of Molecular Cell, Ham et al.1 demonstrate that the metabolite fumarate, when accumulated in cells, can influence mitochondrial quality …

www.sciencedirect.com/science/arti...

Have a look at our views on the recent paper about fumarate and mitophagy.

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Submit your best work to Oncogenesis — and be part of a growing, high-impact platform.

Oncogenesis is proud to announce that our 2024 #ImpactFactor has increased to 6.4, placing us 50th out of 326 journals in #Oncology!

🏅 Top 50 Oncology Journal
📈 2024 Impact Factor: 6.4

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Check the details on how the authors targeted the mitochondrial bioenergetics of multiple myeloma-mesenchymal stem cells with Venetoclax to sensitized multiple myeloma cells to Bortezomib.

Discover Liat Drucker's newest findings, now featured in #Oncogenesis

“Myeloma mesenchymal stem cells’ bioenergetics afford a novel selective therapeutic target”

Read the full open access article here: lnkd.in/gB6Z2bws

Check how the authors unravel the intricate role of USP10 in the context of EGF signaling in colon cancer and how it opens the door to a nuanced discussion of the multiple treatment options that may arise from the identification of the USP10-INPP4B interplay.

Groundbreaking research led by Thomas Kietzmann has been featured in #Oncogenesis.

“Ubiquitin-specific protease 10 determines colorectal cancer outcome by modulating epidermal growth factor signaling via INPP4B”

Read the full open access article here: www.nature.com/articles/s41...