Aligned with ferroptosis restricting circulating cancer cells, the BDH2β2,5-DHBA pathway protects mesenchymal cells from ferroptosis in the blood, boosting their capacity to seed secondary organs.
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Restoring BDH2 or supplementing 2,5-DHBA rescues iron transfer, lysosomal pH, and ferroptosis resistance.
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When BDH2 is lost, iron gets trapped in lysosomes, lysosomal pH rises, and contacts weaken. As a consequence, mesenchymal cells become highly vulnerable to ferroptosis.
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We show that BDH2 is a key regulator of inter-organelle Fe(II) transfer. In melanocytic cells, BDH2 localizes at mitochondriaβlysosome contacts. There it produces the siderophore 2,5-DHBA, which ferries Fe(II) into mitochondria. This supports respiration and lysosomal acidification.
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Excited to share my PhD paper out now in Nature Metabolism! π¨ We studied how intracellular iron trafficking controls ferroptosis vulnerability in melanoma. Shout-out to @agostinislab.bsky.social and all collaborators who made this possible! @natmetabolism.nature.com
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Review title
Review sections graphic
Sub compartments of mitochondria graphic
Mitochondrial.dynamics graphic
π¬ Curious about #mitochondria #imaging but unsure where to begin? Our review might help! πππ§ͺ
www.annualreviews.org/content/jour...
#Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA
17.11.2024 16:46 β π 145 π 43 π¬ 7 π 3
Let's bring the #CellDeath community together here on π¦
Just get in touch to join this Starter Pack
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16.11.2024 09:41 β π 62 π 44 π¬ 17 π 1
Hi Bluesky community ππ»π¦ just moved in! Iβm a PhD student @ VIB (Belgium), interested in iron metabolism, membrane contact sites, ferroptosis, and cancer biology. If this sounds like something for you, take a look at our latest preprint π www.researchsquare.com/article/rs-5...
15.11.2024 23:20 β π 7 π 1 π¬ 0 π 0
Nature Metabolism publishes studies that advance our understanding of metabolic and homeostatic processes in physiology and disease.
https://www.nature.com/natmetab/
ContactCTC is the only journal dedicated to discuss Inter-Organelle Communication. OpenAcess, PeerReviewed.
https://journals.sagepub.com/home/ctca From SAGE Publishing.
Editor-in-Chief: Tim Levine, UCL.
Researching the interplay between factors underlying metabolic health and disease, including diet, age, environment, and genetics, for the prevention and treatment of widespread chronic diseases. https://hsph.harvard.edu/department/molecular-metabolism/
We publish rigorous and engaging articles spanning from cellular bioenergetics to whole-body physiology. https://www.cell.com/trends/endocrinology-metabolism/home
Reviews journal by Cell Press publishes articles covering all aspects of human diseases, diagnostics, therapeutics, and disease prevention. Posts are by the editor, Dr. Aliki Perdikari. Explore more at: https://www.cell.com/trends/molecular-medicine/home
VIB-KU Leuven Center for Cancer Biology - our ambition is to contribute to a better understanding of the biology underlying cancer initiation, progression and metastatic dissemination.
π²π½β‘π§πͺ. LCGEJ, @liigh-unam.bsky.social Alumni.
Interest in cancer started with @daniela-oaks.bsky.social as undergrad.
Current PhD @marinelab.bsky.social applying bioinformatics.
PhD, Senior editor for oncology at Nature Medicine @natmedicine.bsky.social. Previously at Nature Reviews Cancer. Views are my own.
Postdoctoral researcher in the Molecular Neurogenetics Lab, Lund University.
π§π½ββοΈππ½ββοΈπ΄π½ββοΈππ½ββοΈ
The IMP is a leading life science centre in Europe with 220 researchers from 40 countries. Part of the ViennaBioCenter.
Vienna BioCenter Scientific Training Unit, we share opportunities that exist at the Vienna BioCenter (VBC), which include our PhD, Post Doc and Summer School programs. https://training.vbc.ac.at/
Postdoc at the Mancuso Lab, former De Strooper lab memberπ§
π΅πΉπ§πͺ Neuroscience & Dementia research π§ In a love affair with iPSCs & neurons 𧫠PostDoc Fellow @ Rosa Rademakers lab @ CMN_VIB 𧬠Science Communication π£ Women in STEM advocate π©βπ¬ Previously PhD Baekeland Fellow @ Bart De Strooper lab & Janssen Pharmaceutica π§ͺ
Look deeply and patiently into nature, and everything will become clearer.
Scientist investigating peroxisomes and metabolism and teaching Physiology at the University of Granada (Spain). Granada - BCN - NYC - CPH - Granada https://sites.google.com/view/perbiometlab/home
Forum for early career researchers to share and learn immunometabolism research
Professor, Biomedical Engineering, University of Michigan. Our lab works in the area of cancer metabolism, exosomal metabolism, tumor micro environment, metabolic flux analysis, and machine learning.
Labwebsite: https://nagrath.bme.umich.edu/
Scientist interested in clinical mass spectrometry #metabolomics #proteomics #lipidomics #bone #metabolism #cancer #bileacidsπ¨π΄π¬π§π¦πΉ πGraz - AT
Biochemist and engineer. Chair/Head of Systems Medicine @Imperial π¬π§ Research Director @CNRSπ«π· Adjunct Professor @McGill π¨π¦ human #metabolome #microbiome #holobiont in #cardiometabolic diseases and #environmental ecosystems too #OneHealth
Assistant Professor at UTSW Medical Center
www.nils-burger-lab.com
Postdoc Chouchani Lab at Dana-Farber Cancer Institute and Harvard Medical School | PhD University of Cambridge - Murphy Lab MRC Mitochondrial Biology Unit
