Jan Radford

Promotional graphic for BMJ Medicine featuring an illustration of a person with a magnifying glass, analysing icons representing research methods and reporting, including charts and gears. The image includes text that reads 'NEW: Research Methods and Reporting,' with a call to action reading 'READ NOW.' There's also a reference to case studies and a guide for researchers

Calling all researchers and educators📣 This new RMR by @trishgreenhalgh.bsky.social on how to conduct effective case studies, offers guidance for using them for learning & decision-making.

Essential reading for robust research!

https://bit.ly/47PL01l

New research featuring DCRI’s Stephen Greene assessed the effects of GLP-1RAs on heart failure hospitalization and cardiovascular death across populations with varying type and number of CKM comorbidity, finding the treatment helped reduce deaths. Read more: onlinelibrary.wiley.com/doi/10.1002/...

Ancient hybridization underlies tuberization and radiation of the potato lineage "Interspecific hybridization may trigger species radiation by creating allele combinations and traits. Cultivated potato and its 107 wild relatives from the Petota lineage all share the distinctive trait of underground tubers, but the underlying mechanisms for tuberization and its relationship to extensive species diversification remain unclear. Through analyses of 128 genomes, including 88 haplotype-resolved genomes, we revealed that Petota is of ancient hybrid origin, with all members exhibiting stable mixed genomic ancestry, derived from the Etuberosum and Tomato lineages ca. 8-9 million years ago. Our functional experiments further validated the crucial roles of parental genes in tuberization, indicating that interspecific hybridization is a key driver of this innovative trait. This trait, along with the sorting and recombination of hybridization-derived polymorphisms, likely triggered the explosive species diversification of Petota by enabling occupation of broader ecological niches. These findings highlight how ancient hybridization fosters key innovation and drives subsequent species radiation."

Ancient hybridization underlies tuberization and radiation of the potato lineage

We studied over 160,000 pregnancies to show how your postcode affects you and your baby New research shows fast-food outlets and with few healthy food options was strongly linked to indicators of poorer health for both mother and baby.

A great study of over 160,000 Melbourne pregnancies to show how your postcode affects you and your baby
theconversation.com/we-studied-o...

Mechanisms of enhanced renal and hepatic erythropoietin synthesis by sodium–glucose cotransporter 2 inhibitors Abstract. Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of major heart failure events, an action that is statistically linked to enhanc

#Medsky🧪 #Cardiosky #pharmsky #publichealth
#SGLT2 inhibitors alleviate inflammation-induced functional #irondeficiency by suppressing hepcidin & mobilizing iron stores, thereby enhancing iron availability for erythropoiesis and tissue function.

National Climate Change Risk Assessment out now 👇🏽

Risk to current ecosystems VERY HIGH. Rick by 2050 VERY HIGH to SEVERE

Our antibiotic stewardship in Australian #generalpractice co-design phase paper is out. www.mdpi.com/3493602

Apolipoprotein B outperforms low density lipoprotein particle number as a marker of cardiovascular risk in the UK Biobank - PubMed This study suggests that ApoB is a more accurate marker for cardiovascular risk than LDL-P when discordant, as marked by ApoB levels in excess of LDL-P. Notably, risk was already elevated at as little...

"This study suggests that ApoB is a more accurate marker for cardiovascular risk than LDL-P when discordant, as marked by ApoB levels in excess of LDL-P." Analysis of UK Biobank data by Elizabeth Epstein, et al. #cardiosky pubmed.ncbi.nlm.nih.gov/40887080/

Effect of antidepressants on death in patients with heart failure: a systematic review and meta-analysis - Heart Failure Reviews Depression is associated with an increased risk of death in patients with heart failure (HF); however, the association between the use of antidepressants and HF prognoses remains controversial. Theref...

#gerontology #geriatrics #primaryhealthcare #health #ehealth #telemedicine #cardiology #publichealth #neurology #mentalhealth #NCDs

Antidepressants
increase the risk of death
in patients with heart failure:

TCAs RR = 1.30
SSRIs RR = 1.26
SNRIs RR = 1.17

link.springer.com/article/10.1...

JAMA Network Open article: "Participation of Women in Cardiovascular Trials From 2017 to 2023 A Systematic Review". Includes 2 line graphs showing Median Participation: Prevalence Ratio in Cardiovascular Trials.

From @jamanetworkopen.com: Despite advances in trial design, women are underrepresented in cardiovascular research, especially for high-risk conditions like arrhythmias, coronary heart disease, and acute coronary syndrome.

#ESCCongress #WCCardio

ja.ma/45TKJYw

Weight loss drugs can halve heart patients’ risk of early death, study finds GLP-1 agonists could be given to millions with heart conditions to help them stay out of hospital and live longer Weight loss drugs can reduce by half the risk of heart patients being hospitalised or...

Weight loss drugs can halve heart patients’ risk of early death, study finds #Science #HealthandMedicine #Cardiology #WeightLoss #HeartHealth #MedicalResearch

Doctors find drug that is better than aspirin at preventing heart attacks Discovery that clopidogrel is a more effective blood thinner could transform health guidelines worldwide Doctors have found a drug that is better than aspirin at preventing heart attacks and strokes,...

Doctors find drug that is better than aspirin at preventing heart attacks #Science #HealthandMedicine #Cardiology #HeartHealth #AspirinAlternatives

JAMA article displays a graph titled 'Primary Outcome' comparing 'Culprit-only revascularization' and 'Complete revascularization' over 12 months. The former shows a higher cumulative probability of death, myocardial infarction, or stroke.

@jama.com: Among patients w/ NSTEMI and multivessel disease, FFR-guided complete revascularization reduced risk of death, nonfatal myocardial infarction, revascularization, and stroke at 1 year compared with culprit-only revascularization.

#ESCCongress #WCCardio

ja.ma/3VqoBQB

An editorial from JAMA, published online August 31, 2025, titled "Lifelong Anticoagulation After AF Ablation—Time to Reconsider?" by Edward P. Gerstenfeld, MD, and Xiang Wen Lee, MBBS. The article discusses the controversies surrounding ablation therapy.

Editorial: Discontinuing anticoagulation therapy after AF ablation may be beneficial for patients at intermediate stroke risk and high bleeding risk, although careful monitoring and shared decision-making are essential.

#ESCCongress #WCCardio

ja.ma/4n8N8Wq

Flowchart outlining a study on Semaglutide and Tirzepatide for heart failure. It shows patient filtering and eligibility criteria in emulated trials and expanded populations. The study includes patients initiating semaglutide, tirzepatide, or sitagliptin across the US.

From @jama.com: In patients w cardiometabolic #HFpEF, #semaglutide and #tirzepatide reduced the risk of hospitalization for heart failure or all-cause mortality vs sitagliptin, but tirzepatide offered no additional benefit over semaglutide.

#ESCCongress #WCCardio

ja.ma/4nbWuRk

Strep ❤️

Viridans streptococci DNA found in ~42% of coronary plaques, forming biofilms ignored by macrophages

Once fragments escape, TLR2 senses them—potentially triggering an inflammatory response that disrupts plaque stability and increases heart attack risk

www.ahajournals.org/doi/10.1161/...

Heart failure: time to prioritise prevention Heart failure is a major contributor to the global burden of cardiovascular disease, affecting more than 55 million people. Prevalence has more than doubled over the past three decades, and it is the ...

Heart failure: time to prioritise prevention @thelancet.com www.thelancet.com/journals/lan...

Potassium-rich diet may cut risk of heart failure by 24%, study suggests Eating foods such as avocados, bananas and spinach linked to lower risk of heart conditions, hospitalisation or death

www.theguardian.com/society/2025...

Gut-brain nexus: Mapping multimodal links to neurodegeneration at biobank scale Co-occurring disorders of the gut-brain axis combined with genetic and proteomic data can better predict neurodegenerative risk.

he more data for an individual, the better we are getting for accurate prediction of risk for Alzheimer's and Parkinson's diseases, adding layers related to the gut-brain axis
science.org/doi/full/10....

New review introduces the LEAD framework—Leveraging Evidence and Data—to strengthen pediatric screening protocols for familial hypercholesterolemia (FH). Early detection, backed by solid data, can save lives.
Read more: ow.ly/fPIT50WN1F9

Your DNA sequence reveals a rare mutation. Will you get the disease, i.e. penetrance? A new study using machine learning predicts this across 10 common diseases, 1,600 genomic variants
New @science.org
science.org/doi/10.1126/...

Kids with ‘developmental delay’ will be diverted from the NDIS. But how do you know if your child is delayed? Developmental delay might mean a toddler isn’t using sentences when expected, or not meeting milestones such as walking or feeding themself.

Kids with ‘developmental delay’ will be diverted from the NDIS. But how do you know if your child is delayed?
theconversation.com/kids-with-de...

Long COVID is more than fatigue. Our new study suggests its impact is similar to a stroke or Parkinson’s Long COVID isn’t just a bunch of lingering symptoms. A new study shows it can stop peoole doing what they want to do, and need to do.

Long COVID is more than fatigue. Our new study suggests its impact is similar to a stroke or Parkinson’s
theconversation.com/long-covid-i...

Science has more than doubled our life expectancy, revolutionized our quality of life, and powered unprecedented technological advancement. But can we afford to take scientific progress for granted? What happens when science funding is slashed, diversity is suppressed, and pseudoscience takes hold?

Graph titled 'Adjusted Percentage With 30% or Greater Reduction in Pain Severity (Primary Outcome)'. It plots 'Usual care plus', 'painTRAINER', and 'Health coach' over 12 months, showing pain reduction percentages.

Remote, scalable cognitive behavioral therapy–based chronic pain programs are effective for treating individuals with high-impact #chronicpain.

ja.ma/41JDFfM

#Exercise training in #HFpEF
💚ET works better than #exercise counselling
💚RT dose in combination w AT matters
Discover more 👉doi.org/10.1093/eurj...
@EJPCEiC @ESC_Journals @AboyansV @PeroneFrancesco @justvick @PTBuketAkinci @HFA_President
Editorial 👉doi.org/10.1093/eurj...

A Silent Legacy of Lipids. 🫀

Familial hypercholesterolemia (FH) isn’t rare—it’s just rarely diagnosed.

One family’s story shows the generational toll of undetected FH, and the hope that comes with awareness, testing & treatment.

www.sciencedirect.com/science/arti...

#HeartHealth #FH #Cardiology

Does weightlifting improve bone density? Bone density is strongly linked to your risk of a fracture.

Does weightlifting improve bone density?
theconversation.com/does-weightl...