Poster A-098: Pfam database in 2025 – towards expanding protein families coverage
Nicole Morveli Flores
Session A: 21/07/2025
10:00 – 11:20 and
16:00 – 16:40 BST
Image credit: BioImage Archive accession S-BSST584.
Design credit: Karen Arnott/EMBL-EBI
InterProScan 6: a modern large-scale protein function annotation pipeline
Matthias Blum
21/07/2025 14:20
Room 03A
Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI
Poster A-205: Carbohydrate active enzymes in Pectobacteriaceae: coevolving enzyme sets and host adaptation
Emma Hobbs
Session A: 21/07/2025
10:00 – 11:20 and
16:00 – 16:40 BST
Image credit: BioImage Archive accession S-BSST584.
Design credit: Karen Arnott/EMBL-EBI
Accelerating protein family classification in InterPro with AI innovations
Matthias Blum
22/07/2025 16:40
Room 12
Image credit: BioImage Archive accession S-BSST584.
Design credit: Karen Arnott/EMBL-EBI
🧬 The InterPro/Pfam team will be presenting at #ISMB2025 next week in Liverpool!
🎤 Multiple talks & 📊 posters on protein analysis & classification
💻🧪
18.07.2025 14:11 — 👍 1 🔁 1 💬 0 📌 0
The InterPro/Pfam team members attending ISMB/ECCB 2025: Alex Bateman, Emma Hobbs, Matthias Blum, Nicole Morvelli, Antonina Andreeva
Image credit: BioImage Archive accession S-BSST584.
Design credit: Karen Arnott/EMBL-EBI
🧬 The InterPro/Pfam team will be presenting at #ISMB2025 next week in Liverpool!
Join us July 20-24 at the world's largest #bioinformatics conference!
#ISMBECCB2025 #ProteinAnalysis #ComputationalBiology
💻🧪
18.07.2025 14:09 — 👍 2 🔁 1 💬 0 📌 0
JOBIM 2025 logo
8 to 11th July 2025 Bordeaux
🧬✨ Excited to present at @jobim2025.bsky.social this week in Bordeaux!
🎤 Talk 08/07 16:50, amphi E: Pfam: embracing AI/ML by @typhainepl.bsky.social
📊 Poster #97: InterPro: Accelerating Protein Annotation with AI by @matthiasblum.bsky.social
💻🧪
07.07.2025 08:21 — 👍 3 🔁 0 💬 0 📌 2
Level up your protein prediction skills with the updated EMBL-EBI Training AlphaFold practical course.
Now featuring #AlphaFold Server and AlphaFold 3. Start your training today: www.ebi.ac.uk/training/onl...
AlphaFold, developed by @ebi.embl.org and Google DeepMind.
26.06.2025 08:36 — 👍 9 🔁 3 💬 0 📌 0
Schematic diagram showing taste signal transmission between the tongue (with taste buds that contain taste cells harbouring GPCRs) and brain. Taste GPCRs are activated by specific food compounds, recruit specific G proteins that further induce intracellular calcium release. Adapted from [https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/Unit_IV_-_Special_Topics/28:_Biosignaling_-_Capstone_Volume_I/28.18:_Signal_Transduction_-_Taste_(Gustation)].
Does taste depend on our genes? Discover how variations in taste receptors—from TAS2Rs that gate bitterness to olfactory genes that make cilantro taste soapy—and even pain receptors for spice shape what we love (and hate) on our plates. Read more: proteinswebteam.github.io/interpro-blo... 💻🧪👅🧬
26.06.2025 09:44 — 👍 1 🔁 0 💬 0 📌 0
InterPro 106.0
19th June 2025
Databases updates:
Pfam 37.4
New entries:
683 new entries with:
613 Pfam
78 NCBIfam
30 CDD
4 PANTHER
...
🚀 InterPro 106.0 is now live!
✨ Updated to Pfam 37.4
✨ 683 new entries added
✨ Enhanced protein classification coverage
Explore the latest annotations and discover new protein insights.
Explore it now: interpro.ebi.ac.uk 💻🧪🧬
#Bioinformatics #ProteinScience #Pfam #EMBLEBI
20.06.2025 08:22 — 👍 8 🔁 2 💬 0 📌 0
What’s new in the redesigned PDBe entry pages?
🧪 Cleaner layout
🧪 Interactive 3D viewers
🧪 Contextual annotations
🧪 Easier navigation
See for yourself:
wwwdev.ebi.ac.uk/pdbe/entry/p...
#PDBeBeta #Bioinformatics #Biochemistry #Science
16.06.2025 15:40 — 👍 11 🔁 5 💬 0 📌 0
InterPro just got one of its biggest updates ever.
Now with 1.8 billion AI-driven protein annotations, AlphaFold-based TED domains, and viral proteins from the Big Fantastic Virus Database (BFVD).
See it all at www.ebi.ac.uk/interpro
🖥️🧬
@interprodb.bsky.social
12.06.2025 15:27 — 👍 25 🔁 16 💬 0 📌 0
@martinsteinegger.bsky.social
03.06.2025 12:55 — 👍 0 🔁 0 💬 0 📌 0
CATH-Gene3D annotation visualised on BFVD structure prediction of UniProt A0A075FDU7
🦠🧬Exciting news! BFVD predicted viral protein structures are now available in @InterProDB!
For the first time, explore InterPro functional annotations directly on 3D structures of viral proteins not covered by AlphaFold DB. This bridges a critical gap in structural virology research.
03.06.2025 12:47 — 👍 29 🔁 9 💬 2 📌 1
We are saddened to hear of the passing of Daniel Kahn, the creator of the ProDom database. His pioneering work in protein domain classification laid important groundwork for InterPro and the wider bioinformatics community. We honour his lasting contributions. 🧬🕊️
20.05.2025 08:29 — 👍 1 🔁 0 💬 0 📌 0
🧬 MAJOR UPDATE: InterPro-N matches now available in InterPro!
1.8 billion AI-driven protein annotations developed with Google DeepMind are now live.
✨ Look for the sparkles icon to identify them
📊 Options menu lets you view: InterPro only | InterPro-N-only | Stacked
💻🧪
15.05.2025 17:07 — 👍 4 🔁 1 💬 0 📌 0
TED domains alongside InterPro annotations for UniProt P05067
🔍 NEW: TED domains in InterPro 105.0!
For the first time, see AlphaFold-derived structural domains directly alongside InterPro annotations in one powerful visualisation. Bridging the sequence-structure divide in protein analysis. 💻🧪
Explore now: www.ebi.ac.uk/interpro/pro...
08.05.2025 14:54 — 👍 13 🔁 5 💬 0 📌 0
InterPro 105.0: AI for protein classification
InterPro 105.0 is now live. This AI-driven update makes it easier than ever to explore the protein universe
📝 Check out our new blog post highlighting the groundbreaking features in InterPro 105.0!
Learn how InterPro-N, TED domains and viral protein structures are transforming protein classification: ebi.ac.uk/about/news/u...
01.05.2025 16:35 — 👍 3 🔁 1 💬 0 📌 0
InterPro 105.0
24th April 2025
Databases updates
Pfam 37.3
PROSITE patterns 2025_01
PROSITE profiles 2025_01
HAMAP 2025_01
New entries
342 new entries with:
318 Pfam
40 NCBIfam
12 Prosite profiles
6 PANTHER
5 CDD
New features
InterPro-N annotations
BFVD structure predictions
Simplified structure pages
📢InterPro release 105.0 is live!
✨Update to Pfam 37.3, PROSITE patterns 2025_01
PROSITE profiles 2025_01 and HAMAP 2025_01
✨342 new entries
✨Addition of InterPro-N annotations
✨Addition of BFVD structure predictions from @martinsteinegger.bsky.social's lab
Have a look: ebi.ac.uk/interpro/htt...
💻🧪🆕
24.04.2025 16:07 — 👍 19 🔁 10 💬 1 📌 0
LLM generated summaries for protein classification at InterPro
Missed our latest webinar about LLM generated summaries for protein classification at InterPro delivered by
@matthiasblum.bsky.social?
The recording is now available: lnkd.in/ei4fKGXd
11.04.2025 08:50 — 👍 7 🔁 1 💬 0 📌 0
Want to use the InterPro API but not sure how to start? Join this upcoming workshop, where @typhainepl.bsky.social will guide you through the fundamentals and practical applications. Discover how to integrate this powerful tool into your workflow! Register now to secure your spot. 💻🧪
02.04.2025 09:36 — 👍 5 🔁 2 💬 0 📌 0
Are you going to ISMB/ECCB 2025 @iscb.bsky.social in Liverpool 🇬🇧? Register for our tutorial on 'Genomic Variant Interpretation & prioritisation for clinical research'. More info: tinyurl.com/ahav9djn
#genomics #bioinformatics
25.03.2025 14:38 — 👍 10 🔁 3 💬 0 📌 3
InterProScan Version: 5.73-104.0
6th February 2025
Databases updates:
Pfam 37.2
NCBIfam 17.0
CDD 3.21
Ways to access:
1) InterPro website: sequence search
2) Local installation
Software download
Docker container
🆕 New version of InterProScan: 5.73-104.0
3 ways to use it:
1️⃣ Sequence search on the InterPro website: ebi.ac.uk/interpro/sea...
2️⃣ Local installation: interproscan-docs.readthedocs.io/en/v5/Instal...
3️⃣ Local installation using a container: interproscan-docs.readthedocs.io/en/v5/HowToU...
💻🧪
25.02.2025 11:22 — 👍 4 🔁 3 💬 0 📌 0
InterPro 104.0
6th February 2025
Databases udpates:
Pfam 37.2, NCBIfam 17.0, CDD 3.21
661 new entries, containing:
663 Pfam
5 NCBIfam
5 PANTHER
9 CDD
New features:
Redesigned protein viewer for sequence searches
Wikipedia articles for Pfam clans
Addition of PTM from the PRIDE database
🔈InterPro release 104.0 is live!
✨Update to Pfam 37.2, NCBIfam 17.0, CDD 3.21.
✨661 new entries, including 682 signatures from the Pfam (663), NCBIfam (5), PANTHER (5), CDD (9) databases. Have a look: ebi.ac.uk/interpro/ 💻🧪
06.02.2025 14:19 — 👍 4 🔁 4 💬 0 📌 0
New webinar series featuring InterPro, register now!
14.02.2025 09:11 — 👍 1 🔁 1 💬 0 📌 0
RT please: Just 1.5 months away from our joint 3DBioinfo/3DSIG amazing conference!
These are our two great keynote speakers!
@rolanddunbrack.bsky.social & @silviaosuna.bsky.social!
Check our preliminary programme here:
www.iscb.org/3dbioinfo202...
Registration link:
www.iscb.org/3dbioinfo202...
13.02.2025 10:41 — 👍 18 🔁 10 💬 1 📌 1
InterPro 104.0
6th February 2025
Databases udpates:
Pfam 37.2, NCBIfam 17.0, CDD 3.21
661 new entries, containing:
663 Pfam
5 NCBIfam
5 PANTHER
9 CDD
New features:
Redesigned protein viewer for sequence searches
Wikipedia articles for Pfam clans
Addition of PTM from the PRIDE database
🔈InterPro release 104.0 is live!
✨Update to Pfam 37.2, NCBIfam 17.0, CDD 3.21.
✨661 new entries, including 682 signatures from the Pfam (663), NCBIfam (5), PANTHER (5), CDD (9) databases. Have a look: ebi.ac.uk/interpro/ 💻🧪
06.02.2025 14:19 — 👍 4 🔁 4 💬 0 📌 0
1/ 🌟At Europe PMC, we are at the heart of open science ♥️🔓
Our mission? To support open science, promote innovation, and connect publications with other research outputs to empower users worldwide.
But how do we do it? Let’s break it down 🧵👇
30.01.2025 09:15 — 👍 6 🔁 4 💬 1 📌 0
Parkinson's disease molecular mechanisms.
Source: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)61393-3/fulltext#fig3
🧬🧪💻 New blog post: Diving deep into the key proteins behind Parkinson's disease. From α-synuclein to LRRK2, we're unravelling the molecular mysteries that could hold the key to treatment breakthroughs. Read more: proteinswebteam.github.io/interpro-blo... #Parkinsons #Neuroscience
31.01.2025 16:19 — 👍 4 🔁 1 💬 0 📌 0
InterPro website Help page
🔍 Lost in InterPro data? Our redesigned Help page has you covered! From quick answers to deep dives into protein families, find exactly what you need at www.ebi.ac.uk/interpro/help/ 💻🧪
24.01.2025 11:03 — 👍 8 🔁 2 💬 0 📌 0
Protein structure prediction from the AlphaFold Database
Prediction confidence scores help #AlphaFold users gauge the reliability of protein structure predictions. 🖥️🧬
But things get more challenging for protein families.
A new method helps improve low confidence predictions within protein families.
academic.oup.com/bioinformati...
16.12.2024 09:28 — 👍 17 🔁 7 💬 0 📌 0
Example of Profile HMM page for Pfam PF22971. It contains HMM data and Profile HMM logo
🆕The member database signature pages have undergone a thoughtful reorganisation to improve information accessibility.
1) Curation data are now in Overview
2) HMM information and logo are now in Profile HMM
Have a look: www.ebi.ac.uk/interpro/ent...
16.01.2025 11:39 — 👍 1 🔁 2 💬 0 📌 0
🆕We've implemented a new “Curation status” filter to help users distinguish between different types of entries (curated vs AI) in the Browse by InterPro and Member DB, have a look: www.ebi.ac.uk/interpro/ent... 💻🧪
10.01.2025 17:20 — 👍 2 🔁 0 💬 0 📌 0
2024 was a big year for InterPro! 🎉
🔹 Celebrated InterPro 100 with new features
🤖 Added AI-generated entries
🌟 Improved tools & navigation
📚 Expanded data with new signatures
💬 Joined Bluesky to connect with you!
Thank you for your support—here’s to 2025! 🚀
💻🧪
23.12.2024 10:33 — 👍 0 🔁 0 💬 0 📌 0
💻 We are the Structural Bioinformatics and Computational Biology track of the International Society for Computational Biology (ISCB)
Professor at the University of Victoria. Structural biologist studying phosphoinositides, membrane signalling, and nanobodies using HDX-MS, x-ray crystallography and cryo EM
Proteins. Biochemistry. Pharmacy 𓂀
Compbiologist 🧬🦠| PI JRaviLab |
NewPI, Biomedical Informatics, CU Anschutz |
Founder, R-Ladies Aurora | AsiaR | R-Ladies East Lansing | Women+ Data Science
Obsessed with all things protein structure and other works of art. Love to spend time with my friends and family (including my four-legged kid).
Senior Scientific Training Office - Digital Learning for EMBL-EBI Training
Co-founder/CEO KPL ApS , #Proteomics researcher in Copenhagen, Denmark at Københavns Universitet, NNF Center for Protein Research #science, #technology, #culture, memes and vibes.
ARUK-RAD Fellow at the University of Dundee. I use proteomics to understand how microglia contribute to Alzheimer's Disease. GK for TNT Netball Club.
Structural Biology | Glycobiology | Proteomics | views are my own | 🏴🇬🇧🇮🇹🇪🇺
Evolutionary cell biology @EMBL
evonuclab.org
Professor at DTU NNF Center for Biosustainability with interest in bioactive compounds, comp. biol., WGS and much more; hobby photographer. Views are my own.
Professor of Biophysics, Drug Discovery, Photographer, Traveller and a Cultural succupus.
Scottish computational biologist working in the Benakis lab at LMU - @ISD_Research - Microbiota and stroke
Biochemist interested in membranes and proteins, specially when they mix. https://research.uv.es/membrana/
Dean @ccbiologiquesUV.bsky.social @uv.es 🇪🇺
Assoc. prof. at LUMC (Experimental Bacteriology/CMAT) @unileiden. Cdiff, DNA replication, AMR, microbiome, anaerobes. Clostpath Steering committee. Education officer ESGCD. Previously: @unigroningen and @mitofficial.
Assistant Professor @ Dep. Molecular Pharmaceutics, College of Pharmacy, @utah.edu | Molecular Pharmaceutics | ImmunoEngineering | Drug & Gene Delivery | Views are my own
The Saccharomyces Genome Database (SGD) provides comprehensive biological information for the budding yeast Saccharomyces cerevisiae along with search and analysis tools to explore these data, enabling scientific discovery.
She/Her. Project leader at @ebi. Developer. STEM ambassador. Creator of the Protein families game. Traveller. Photo. SBK dancer.
Protein Historian
Specially Appointed Associate Professor at the Earth-Life Science Institute, Institute of Science Tokyo
Affiliate Research Scientist at the Blue Marble Space Institute of Science
My academic journey: 🇺🇸 → 🇮🇱 → 🇯🇵