InterPro's Avatar

InterPro

@interprodb.bsky.social

InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. ebi.ac.uk/interpro/

394 Followers  |  381 Following  |  27 Posts  |  Joined: 19.11.2024  |  1.9225

Latest posts by interprodb.bsky.social on Bluesky

Poster A-098: Pfam database in 2025 – towards expanding protein families coverage
Nicole Morveli Flores
Session A: 21/07/2025
10:00 – 11:20 and
16:00 – 16:40 BST
Image credit: BioImage Archive accession S-BSST584. 
Design credit: Karen Arnott/EMBL-EBI

Poster A-098: Pfam database in 2025 – towards expanding protein families coverage Nicole Morveli Flores Session A: 21/07/2025 10:00 – 11:20 and 16:00 – 16:40 BST Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI

InterProScan 6: a modern large-scale protein function annotation pipeline
Matthias Blum 
21/07/2025 14:20 
Room 03A 
Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI

InterProScan 6: a modern large-scale protein function annotation pipeline Matthias Blum 21/07/2025 14:20 Room 03A Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI

Poster A-205: Carbohydrate active enzymes in Pectobacteriaceae: coevolving enzyme sets and host adaptation
Emma Hobbs
Session A: 21/07/2025
10:00 – 11:20 and
16:00 – 16:40 BST
Image credit: BioImage Archive accession S-BSST584. 
Design credit: Karen Arnott/EMBL-EBI

Poster A-205: Carbohydrate active enzymes in Pectobacteriaceae: coevolving enzyme sets and host adaptation Emma Hobbs Session A: 21/07/2025 10:00 – 11:20 and 16:00 – 16:40 BST Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI

Accelerating protein family classification in InterPro with AI innovations
Matthias Blum 
22/07/2025 16:40
Room 12
Image credit: BioImage Archive accession S-BSST584. 
Design credit: Karen Arnott/EMBL-EBI

Accelerating protein family classification in InterPro with AI innovations Matthias Blum 22/07/2025 16:40 Room 12 Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI

🧬 The InterPro/Pfam team will be presenting at #ISMB2025 next week in Liverpool!
🎤 Multiple talks & 📊 posters on protein analysis & classification
💻🧪

18.07.2025 14:11 — 👍 1    🔁 1    💬 0    📌 0
The InterPro/Pfam team members attending ISMB/ECCB 2025: Alex Bateman, Emma Hobbs, Matthias Blum, Nicole Morvelli, Antonina Andreeva
Image credit: BioImage Archive accession S-BSST584. 
Design credit: Karen Arnott/EMBL-EBI

The InterPro/Pfam team members attending ISMB/ECCB 2025: Alex Bateman, Emma Hobbs, Matthias Blum, Nicole Morvelli, Antonina Andreeva Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI

🧬 The InterPro/Pfam team will be presenting at #ISMB2025 next week in Liverpool!
Join us July 20-24 at the world's largest #bioinformatics conference!
#ISMBECCB2025 #ProteinAnalysis #ComputationalBiology
💻🧪

18.07.2025 14:09 — 👍 2    🔁 1    💬 0    📌 0
JOBIM 2025 logo
8 to 11th July 2025 Bordeaux

JOBIM 2025 logo 8 to 11th July 2025 Bordeaux

🧬✨ Excited to present at @jobim2025.bsky.social this week in Bordeaux!
🎤 Talk 08/07 16:50, amphi E: Pfam: embracing AI/ML by @typhainepl.bsky.social
📊 Poster #97: InterPro: Accelerating Protein Annotation with AI by @matthiasblum.bsky.social
💻🧪

07.07.2025 08:21 — 👍 3    🔁 0    💬 0    📌 2
Video thumbnail

Level up your protein prediction skills with the updated EMBL-EBI Training AlphaFold practical course.

Now featuring #AlphaFold Server and AlphaFold 3. Start your training today: www.ebi.ac.uk/training/onl...

AlphaFold, developed by @ebi.embl.org‬ and Google DeepMind.

26.06.2025 08:36 — 👍 9    🔁 3    💬 0    📌 0
Schematic diagram showing taste signal transmission between the tongue (with taste buds that contain taste cells harbouring GPCRs) and brain. Taste GPCRs are activated by specific food compounds, recruit specific G proteins that further induce intracellular calcium release. Adapted from [https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/Unit_IV_-_Special_Topics/28:_Biosignaling_-_Capstone_Volume_I/28.18:_Signal_Transduction_-_Taste_(Gustation)].

Schematic diagram showing taste signal transmission between the tongue (with taste buds that contain taste cells harbouring GPCRs) and brain. Taste GPCRs are activated by specific food compounds, recruit specific G proteins that further induce intracellular calcium release. Adapted from [https://bio.libretexts.org/Bookshelves/Biochemistry/Fundamentals_of_Biochemistry_(Jakubowski_and_Flatt)/Unit_IV_-_Special_Topics/28:_Biosignaling_-_Capstone_Volume_I/28.18:_Signal_Transduction_-_Taste_(Gustation)].

Does taste depend on our genes? Discover how variations in taste receptors—from TAS2Rs that gate bitterness to olfactory genes that make cilantro taste soapy—and even pain receptors for spice shape what we love (and hate) on our plates. Read more: proteinswebteam.github.io/interpro-blo... 💻🧪👅🧬

26.06.2025 09:44 — 👍 1    🔁 0    💬 0    📌 0
InterPro 106.0
19th June 2025

InterPro 106.0 19th June 2025

Databases updates:
Pfam 37.4

Databases updates: Pfam 37.4

New entries:
683 new entries with:
613 Pfam 
78 NCBIfam
30 CDD
4 PANTHER 
...

New entries: 683 new entries with: 613 Pfam 78 NCBIfam 30 CDD 4 PANTHER ...

🚀 InterPro 106.0 is now live!
✨ Updated to Pfam 37.4
✨ 683 new entries added
✨ Enhanced protein classification coverage
Explore the latest annotations and discover new protein insights.
Explore it now: interpro.ebi.ac.uk 💻🧪🧬
#Bioinformatics #ProteinScience #Pfam #EMBLEBI

20.06.2025 08:22 — 👍 8    🔁 2    💬 0    📌 0
Video thumbnail

What’s new in the redesigned PDBe entry pages?

🧪 Cleaner layout
🧪 Interactive 3D viewers
🧪 Contextual annotations
🧪 Easier navigation

See for yourself:
wwwdev.ebi.ac.uk/pdbe/entry/p...

#PDBeBeta #Bioinformatics #Biochemistry #Science

16.06.2025 15:40 — 👍 11    🔁 5    💬 0    📌 0
Video thumbnail

InterPro just got one of its biggest updates ever.

Now with 1.8 billion AI-driven protein annotations, AlphaFold-based TED domains, and viral proteins from the Big Fantastic Virus Database (BFVD).

See it all at www.ebi.ac.uk/interpro

🖥️🧬

@interprodb.bsky.social

12.06.2025 15:27 — 👍 25    🔁 16    💬 0    📌 0

@martinsteinegger.bsky.social

03.06.2025 12:55 — 👍 0    🔁 0    💬 0    📌 0
CATH-Gene3D annotation visualised on BFVD structure prediction of UniProt A0A075FDU7

CATH-Gene3D annotation visualised on BFVD structure prediction of UniProt A0A075FDU7

🦠🧬Exciting news! BFVD predicted viral protein structures are now available in @InterProDB!
For the first time, explore InterPro functional annotations directly on 3D structures of viral proteins not covered by AlphaFold DB. This bridges a critical gap in structural virology research.

03.06.2025 12:47 — 👍 29    🔁 9    💬 2    📌 1

We are saddened to hear of the passing of Daniel Kahn, the creator of the ProDom database. His pioneering work in protein domain classification laid important groundwork for InterPro and the wider bioinformatics community. We honour his lasting contributions. 🧬🕊️

20.05.2025 08:29 — 👍 1    🔁 0    💬 0    📌 0
Video thumbnail

🧬 MAJOR UPDATE: InterPro-N matches now available in InterPro!
1.8 billion AI-driven protein annotations developed with Google DeepMind are now live.
✨ Look for the sparkles icon to identify them
📊 Options menu lets you view: InterPro only | InterPro-N-only | Stacked
💻🧪

15.05.2025 17:07 — 👍 4    🔁 1    💬 0    📌 0
TED domains alongside InterPro annotations for UniProt P05067

TED domains alongside InterPro annotations for UniProt P05067

🔍 NEW: TED domains in InterPro 105.0!

For the first time, see AlphaFold-derived structural domains directly alongside InterPro annotations in one powerful visualisation. Bridging the sequence-structure divide in protein analysis. 💻🧪

Explore now: www.ebi.ac.uk/interpro/pro...

08.05.2025 14:54 — 👍 13    🔁 5    💬 0    📌 0
InterPro 105.0: AI for protein classification
InterPro 105.0 is now live. This AI-driven update makes it easier than ever to explore the protein universe

InterPro 105.0: AI for protein classification InterPro 105.0 is now live. This AI-driven update makes it easier than ever to explore the protein universe

📝 Check out our new blog post highlighting the groundbreaking features in InterPro 105.0!
Learn how InterPro-N, TED domains and viral protein structures are transforming protein classification: ebi.ac.uk/about/news/u...

01.05.2025 16:35 — 👍 3    🔁 1    💬 0    📌 0
InterPro 105.0
24th April 2025

InterPro 105.0 24th April 2025

Databases updates
Pfam 37.3
PROSITE patterns 2025_01
PROSITE profiles 2025_01
HAMAP 2025_01

Databases updates Pfam 37.3 PROSITE patterns 2025_01 PROSITE profiles 2025_01 HAMAP 2025_01

New entries
342 new entries with:
318 Pfam 
40 NCBIfam
12 Prosite profiles
6 PANTHER 
5 CDD

New entries 342 new entries with: 318 Pfam 40 NCBIfam 12 Prosite profiles 6 PANTHER 5 CDD

New features 
InterPro-N annotations
BFVD structure predictions
Simplified structure pages

New features InterPro-N annotations BFVD structure predictions Simplified structure pages

📢InterPro release 105.0 is live!
✨Update to Pfam 37.3, PROSITE patterns 2025_01
PROSITE profiles 2025_01 and HAMAP 2025_01
✨342 new entries
✨Addition of InterPro-N annotations
✨Addition of BFVD structure predictions from @martinsteinegger.bsky.social's lab
Have a look: ebi.ac.uk/interpro/htt...
💻🧪🆕

24.04.2025 16:07 — 👍 19    🔁 10    💬 1    📌 0
LLM generated summaries for protein classification at InterPro

LLM generated summaries for protein classification at InterPro

Missed our latest webinar about LLM generated summaries for protein classification at InterPro delivered by
@matthiasblum.bsky.social?
The recording is now available: lnkd.in/ei4fKGXd

11.04.2025 08:50 — 👍 7    🔁 1    💬 0    📌 0

Want to use the InterPro API but not sure how to start? Join this upcoming workshop, where @typhainepl.bsky.social will guide you through the fundamentals and practical applications. Discover how to integrate this powerful tool into your workflow! Register now to secure your spot. 💻🧪

02.04.2025 09:36 — 👍 5    🔁 2    💬 0    📌 0
Post image

Are you going to ISMB/ECCB 2025 @iscb.bsky.social in Liverpool 🇬🇧? Register for our tutorial on 'Genomic Variant Interpretation & prioritisation for clinical research'. More info: tinyurl.com/ahav9djn
#genomics #bioinformatics

25.03.2025 14:38 — 👍 10    🔁 3    💬 0    📌 3
InterProScan Version: 5.73-104.0
6th February 2025

InterProScan Version: 5.73-104.0 6th February 2025

Databases updates:
Pfam 37.2
NCBIfam 17.0
CDD 3.21

Databases updates: Pfam 37.2 NCBIfam 17.0 CDD 3.21

Ways to access:
1) InterPro website: sequence search
2) Local installation
Software download
Docker container

Ways to access: 1) InterPro website: sequence search 2) Local installation Software download Docker container

🆕 New version of InterProScan: 5.73-104.0
3 ways to use it:
1️⃣ Sequence search on the InterPro website: ebi.ac.uk/interpro/sea...
2️⃣ Local installation: interproscan-docs.readthedocs.io/en/v5/Instal...
3️⃣ Local installation using a container: interproscan-docs.readthedocs.io/en/v5/HowToU...
💻🧪

25.02.2025 11:22 — 👍 4    🔁 3    💬 0    📌 0
InterPro 104.0
6th February 2025

InterPro 104.0 6th February 2025

Databases udpates:
Pfam 37.2, NCBIfam 17.0, CDD 3.21

Databases udpates: Pfam 37.2, NCBIfam 17.0, CDD 3.21

661 new entries, containing:
663 Pfam 
5 NCBIfam
5 PANTHER 
9 CDD

661 new entries, containing: 663 Pfam 5 NCBIfam 5 PANTHER 9 CDD

New features:
Redesigned protein viewer for sequence searches
Wikipedia articles for Pfam clans
Addition of PTM from the PRIDE database

New features: Redesigned protein viewer for sequence searches Wikipedia articles for Pfam clans Addition of PTM from the PRIDE database

🔈InterPro release 104.0 is live!
✨Update to Pfam 37.2, NCBIfam 17.0, CDD 3.21.
✨661 new entries, including 682 signatures from the Pfam (663), NCBIfam (5), PANTHER (5), CDD (9) databases. Have a look: ebi.ac.uk/interpro/ 💻🧪

06.02.2025 14:19 — 👍 4    🔁 4    💬 0    📌 0

New webinar series featuring InterPro, register now!

14.02.2025 09:11 — 👍 1    🔁 1    💬 0    📌 0
Post image Post image

RT please: Just 1.5 months away from our joint 3DBioinfo/3DSIG amazing conference!
These are our two great keynote speakers!
@rolanddunbrack.bsky.social & @silviaosuna.bsky.social!

Check our preliminary programme here:
www.iscb.org/3dbioinfo202...
Registration link:
www.iscb.org/3dbioinfo202...

13.02.2025 10:41 — 👍 18    🔁 10    💬 1    📌 1
InterPro 104.0
6th February 2025

InterPro 104.0 6th February 2025

Databases udpates:
Pfam 37.2, NCBIfam 17.0, CDD 3.21

Databases udpates: Pfam 37.2, NCBIfam 17.0, CDD 3.21

661 new entries, containing:
663 Pfam 
5 NCBIfam
5 PANTHER 
9 CDD

661 new entries, containing: 663 Pfam 5 NCBIfam 5 PANTHER 9 CDD

New features:
Redesigned protein viewer for sequence searches
Wikipedia articles for Pfam clans
Addition of PTM from the PRIDE database

New features: Redesigned protein viewer for sequence searches Wikipedia articles for Pfam clans Addition of PTM from the PRIDE database

🔈InterPro release 104.0 is live!
✨Update to Pfam 37.2, NCBIfam 17.0, CDD 3.21.
✨661 new entries, including 682 signatures from the Pfam (663), NCBIfam (5), PANTHER (5), CDD (9) databases. Have a look: ebi.ac.uk/interpro/ 💻🧪

06.02.2025 14:19 — 👍 4    🔁 4    💬 0    📌 0

1/ 🌟At Europe PMC, we are at the heart of open science ♥️🔓
Our mission? To support open science, promote innovation, and connect publications with other research outputs to empower users worldwide.

But how do we do it? Let’s break it down 🧵👇

30.01.2025 09:15 — 👍 6    🔁 4    💬 1    📌 0
Parkinson's disease molecular mechanisms.
Source: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)61393-3/fulltext#fig3

Parkinson's disease molecular mechanisms. Source: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)61393-3/fulltext#fig3

🧬🧪💻 New blog post: Diving deep into the key proteins behind Parkinson's disease. From α-synuclein to LRRK2, we're unravelling the molecular mysteries that could hold the key to treatment breakthroughs. Read more: proteinswebteam.github.io/interpro-blo... #Parkinsons #Neuroscience

31.01.2025 16:19 — 👍 4    🔁 1    💬 0    📌 0
InterPro website Help page

InterPro website Help page

🔍 Lost in InterPro data? Our redesigned Help page has you covered! From quick answers to deep dives into protein families, find exactly what you need at www.ebi.ac.uk/interpro/help/ 💻🧪

24.01.2025 11:03 — 👍 8    🔁 2    💬 0    📌 0
Protein structure prediction from the AlphaFold Database

Protein structure prediction from the AlphaFold Database

Prediction confidence scores help #AlphaFold users gauge the reliability of protein structure predictions. 🖥️🧬

But things get more challenging for protein families.

A new method helps improve low confidence predictions within protein families.

academic.oup.com/bioinformati...

16.12.2024 09:28 — 👍 17    🔁 7    💬 0    📌 0
Example of Profile HMM page for Pfam PF22971. It contains HMM data and Profile HMM logo

Example of Profile HMM page for Pfam PF22971. It contains HMM data and Profile HMM logo

🆕The member database signature pages have undergone a thoughtful reorganisation to improve information accessibility.
1) Curation data are now in Overview
2) HMM information and logo are now in Profile HMM
Have a look: www.ebi.ac.uk/interpro/ent...

16.01.2025 11:39 — 👍 1    🔁 2    💬 0    📌 0
Video thumbnail

🆕We've implemented a new “Curation status” filter to help users distinguish between different types of entries (curated vs AI) in the Browse by InterPro and Member DB, have a look: www.ebi.ac.uk/interpro/ent... 💻🧪

10.01.2025 17:20 — 👍 2    🔁 0    💬 0    📌 0
Post image

2024 was a big year for InterPro! 🎉
🔹 Celebrated InterPro 100 with new features
🤖 Added AI-generated entries
🌟 Improved tools & navigation
📚 Expanded data with new signatures
💬 Joined Bluesky to connect with you!
Thank you for your support—here’s to 2025! 🚀
💻🧪

23.12.2024 10:33 — 👍 0    🔁 0    💬 0    📌 0

@interprodb is following 20 prominent accounts