Amy Lloyd

Low-dose metformin requires brain Rap1 for its antidiabetic action Metformin lowers blood glucose by inhibiting Rap1 in ventromedial hypothalamic neurons that regulate glucose balance.

Metformin, the first line drug for Type 2 diabetes, has been used for 60 years without a clearcut mechanism of action. It turns out it's not just reducing glucose output from the liver. Metformin also works via the brain www.science.org/doi/10.1126/...

Back home after a great week in Toronto for #AAIC25 @alzassociation.bsky.social - first time presenting this new work funded by Race Against Dementia with more exciting data to follow! 💙

YouTube video by Alzheimer's Association AAIC 2025 Highlights Reel | Alzheimer's Association

Thank you to the more than 11,700 researchers, clinicians and dementia professionals who joined us in Toronto & online for #AAIC25!

Together, you advanced science and clinical practice and have given hope to all those living with Alzheimer’s and all other dementia.

youtube.com/watch?v=6v9iL-EM9Jc

The human proteomic revolution proceeds with high-throughput assessment, AI analytics, correlation with health and disease, drug interactions, biomarkers
www.cell.com/cell/fulltex...

Sunset over the tay bridge from The school of life sciences building in dundee

One week left to apply for this job!!

I'm looking for a research tech to come and work on Alzheimers and ApoE! If you love cell culture, astrocytes, APOE or just fun science with fun people then come do science with us in beautiful Dundee!
tinyurl.com/a33kjn49

Seriously the sunsets are on point!

Can I join please? 😁

@mancusorenzo.bsky.social

Add me please 😁

🧠Re-sharing this as the list is growing. 🌲
Let me know if I've left you out - or if you think I should add someone! 🧠

go.bsky.app/S6FfsTp

Yes please!

go.bsky.app/Lyzro3M

!WELCOME!

thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.

apologies for missing many of you - please do reply to get added

and remember to repost so the newbies can find us!

Could I be added please? 😁

PXD014502 🚨

TMT Characterisation: iPSC vs HESC; Description: Detailed comparison of human pluripotent stem cells, to determine how hESC and IPSC differ in their protein expression profiles.

🚨 New dataset alert! 🚨

I went to the 1st Tenovus Symposium in St Andrews last night and it was great to see all the exciting research funded by Tenovus! Thankful to them for giving me PhD studentship funding and my first funding post-fellowship! No longer a lab of one 😁🥳

Research Assistant / Associate: Inflammation in frontotemporal dementia Dr Maura Malpetti at University of Cambridge is looking for a Research Assistant / Research Associate to investigate inflammation in frontotemporal dementia.

Dr Maura Malpetti at University of Cambridge is looking for a Research Assistant / Research Associate to investigate inflammation in frontotemporal dementia (this is a second position). Closing date: 8th December
www.dementiaresearcher.nihr.ac.uk/job/research...

Deep proteomic analysis of microglia reveals fundamental biological differences between model systems Lloyd et al. generated a comprehensive microglia proteome database, identifying over 11,000 proteins. Fundamental differences between ex vivo and in vitro microglia associated with protein synthesis, ...

My latest paper, deep proteomic analysis of mouse and human microglia: www.cell.com/cell-reports...