Mark Hartmann

Super interesting!

7) gurken (grk)
[german for cucumbers 🥒]

TGF-alpha-like in Drosophila, fundamental for developmental axis specification during egg formation

Important work!

No #nobelpize @bsky.app !?

@nobelprize.bsky.social is an empty desert… Pity!

#science #research

Cool new single-cell multi-omics tool!

#epigenetics

Nice story – thanks for sharing!

Paul Ehrlich-Preis geht an zwei Entwicklungsbiologen Zwei Pioniere der Epigenetik werden geehrt. Davor Solter und Azim Surani haben das Phänomen der genomischen Prägung entdeckt.

In German:
www.forschung-und-lehre.de/karriere/pau...

Further reading:
www.goethe-university-frankfurt.de/96873415/Pau...

Pioneers of Epigenetics honored: Davor Solter & Azim Surani receive the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize. Their discovery of genomic imprinting revealed why mammals need both parents—opening the field of epigenetics.

#Epigenetics #GenomicImprinting #PaulEhrlichPrize #CanSky #Science

Awesome - congratulations!

The German Science and Humanities Council declares permanent positions the new standard.

Interview with @wickwolfgang.bsky.social & Insa Großkraumbach
@wissenschaftsrat.de

A must-read for all working in higher education and research in Germany!

#Wissenschaft
#Forschung
#WissZeitVG
#IchBinHanna

Entscheidend wird sein, dass Projektbezüge nicht weiter als formale Begründung für Befristungen dienen – ein strukturelles Problem, das das #WissZeitVG bislang erlaubt. Jetzt ist die Chance, das zu ändern.
#Hochschulpolitik #Forschung

Wissenschaftliche Karrieren jenseits der Professur brauchen endlich strukturelle Anerkennung.
Dauerhafte Forschung & Lehre brauchen dauerhafte Perspektiven – nicht endlose Projektbefristungen.

In der PM heißt es: Daueraufgaben sollen zu unbefristeten Stellen führen – genannt werden v. a. IT, Infrastruktur, Wissenschaftsmanagement. Das ist gut, aber: Die wissenschaftliche Fachexpertise darf nicht fehlen. #WissZeitVG

„𝗪𝗶𝗿 𝗯𝗿𝗮𝘂𝗰𝗵𝗲𝗻 𝗲𝗶𝗻𝗲 𝗴𝗿𝘂𝗻𝗱𝗹𝗲𝗴𝗲𝗻𝗱𝗲 𝗥𝗲𝗳𝗼𝗿𝗺.“
„𝗗𝗮𝘀 𝗦𝘆𝘀𝘁𝗲𝗺 𝗶𝘀𝘁 𝗻𝗶𝗰𝗵𝘁 𝗻𝘂𝗿 𝗶𝗻𝘁𝗿𝗮𝗻𝘀𝗽𝗮𝗿𝗲𝗻𝘁, 𝘀𝗼𝗻𝗱𝗲𝗿𝗻 𝗮𝘂𝗰𝗵 𝘇𝘂𝗻𝗲𝗵𝗺𝗲𝗻𝗱 𝘂𝗻𝗮𝘁𝘁𝗿𝗮𝗸𝘁𝗶𝘃.“
@wickwolfgang.bsky.social, Vorsitzender des Wissenschaftsrats
#Wissenschaft #Forschung

Der @wissenschaftsrat.de fordert einen Kulturwandel im Wissenschaftssystem: moderne Personalstrukturen, attraktive Karrierewege, mehr Dauerstellen. Ein längst überfälliger und wichtiger Schritt.

www.wissenschaftsrat.de/SharedDocs/P...
#Wissenschaft #Forschung #WissZeitVG #Hochschulpolitik

Fascinating!

🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome

Very cool!

Congratulations, Muzz!

Exciting

Summer Selection of the International #PhD Program at the German Cancer Research Center (@dkfz.bsky.social)

Apply here: t1p.de/amwgq

#CancerResearch
#DataScience
#Bioinformatics
#SolidCancer
#Leukemia
#ChildhoodCancer
#RareCancer
#CanSky
#OncoSky
#HemeSky

Analysis of multi-condition single-cell data with latent embedding multivariate regression Nature Genetics - Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction...

🦎 Differential expression analysis relies on cluster identities, unless you perform a regression along continuous representation in latent space. LEMUR from @const-ae.bsky.social & @wkhuber.bsky.social does that neatly for scRNA-seq data!
🔗 doi.org/10.1038/s415... 🧪 @naturegenet.bsky.social

Congratulations @metorrespadilla.bsky.social

Do you think the lack of clonal hematopoiesis might be specific to laboratory mice?

Following this idea, is it possible that human clonal hematopoiesis is mostly driven by external stimuli?

Exciting study!

I am especially interested in the observation that upon haematological perturbations a human-like clonal hematopoiesis can be triggered, which is otherwise absent.

#HemeSky

Outstanding contributions to our field and society acknowledged with this year’s ISEH awards. Presentations and award seminars at this year’s annual meeting in Kumamoto iseh.org/page/iseh2025

Actually, not so rare at all!

#RareDiseaseDay

Affecting a substantial part of human kind!

Support research on rare diseases!

Picture from rarediseaseday.org

YouTube video by MRC Weatherall Institute of Molecular Medicine Rare Disease Day 2025: Paediatric Leukaemias

To conclude our #RareDiseaseDay series, we spoke with @ellouka.bsky.social, a clinician scientist researching Paediatric Myelodysplastic Syndromes (MDS) and Juvenile Myelomonocytic Leukaemia (JMML). These are incredibly rare childhood cancers, with no current treatment options available. 🧪