Mark Hartmann

The German Science and Humanities Council declares permanent positions the new standard.

Interview with @wickwolfgang.bsky.social & Insa Großkraumbach
@wissenschaftsrat.de

A must-read for all working in higher education and research in Germany!

#Wissenschaft
#Forschung
#WissZeitVG
#IchBinHanna

Entscheidend wird sein, dass Projektbezüge nicht weiter als formale Begründung für Befristungen dienen – ein strukturelles Problem, das das #WissZeitVG bislang erlaubt. Jetzt ist die Chance, das zu ändern.
#Hochschulpolitik #Forschung

Wissenschaftliche Karrieren jenseits der Professur brauchen endlich strukturelle Anerkennung.
Dauerhafte Forschung & Lehre brauchen dauerhafte Perspektiven – nicht endlose Projektbefristungen.

In der PM heißt es: Daueraufgaben sollen zu unbefristeten Stellen führen – genannt werden v. a. IT, Infrastruktur, Wissenschaftsmanagement. Das ist gut, aber: Die wissenschaftliche Fachexpertise darf nicht fehlen. #WissZeitVG

„𝗪𝗶𝗿 𝗯𝗿𝗮𝘂𝗰𝗵𝗲𝗻 𝗲𝗶𝗻𝗲 𝗴𝗿𝘂𝗻𝗱𝗹𝗲𝗴𝗲𝗻𝗱𝗲 𝗥𝗲𝗳𝗼𝗿𝗺.“
„𝗗𝗮𝘀 𝗦𝘆𝘀𝘁𝗲𝗺 𝗶𝘀𝘁 𝗻𝗶𝗰𝗵𝘁 𝗻𝘂𝗿 𝗶𝗻𝘁𝗿𝗮𝗻𝘀𝗽𝗮𝗿𝗲𝗻𝘁, 𝘀𝗼𝗻𝗱𝗲𝗿𝗻 𝗮𝘂𝗰𝗵 𝘇𝘂𝗻𝗲𝗵𝗺𝗲𝗻𝗱 𝘂𝗻𝗮𝘁𝘁𝗿𝗮𝗸𝘁𝗶𝘃.“
@wickwolfgang.bsky.social, Vorsitzender des Wissenschaftsrats
#Wissenschaft #Forschung

Der @wissenschaftsrat.de fordert einen Kulturwandel im Wissenschaftssystem: moderne Personalstrukturen, attraktive Karrierewege, mehr Dauerstellen. Ein längst überfälliger und wichtiger Schritt.

www.wissenschaftsrat.de/SharedDocs/P...
#Wissenschaft #Forschung #WissZeitVG #Hochschulpolitik

Fascinating!

🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome

Very cool!

Congratulations, Muzz!

Exciting

Summer Selection of the International #PhD Program at the German Cancer Research Center (@dkfz.bsky.social)

Apply here: t1p.de/amwgq

#CancerResearch
#DataScience
#Bioinformatics
#SolidCancer
#Leukemia
#ChildhoodCancer
#RareCancer
#CanSky
#OncoSky
#HemeSky

Analysis of multi-condition single-cell data with latent embedding multivariate regression Nature Genetics - Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction...

🦎 Differential expression analysis relies on cluster identities, unless you perform a regression along continuous representation in latent space. LEMUR from @const-ae.bsky.social & @wkhuber.bsky.social does that neatly for scRNA-seq data!
🔗 doi.org/10.1038/s415... 🧪 @naturegenet.bsky.social

Congratulations @metorrespadilla.bsky.social

Do you think the lack of clonal hematopoiesis might be specific to laboratory mice?

Following this idea, is it possible that human clonal hematopoiesis is mostly driven by external stimuli?

Exciting study!

I am especially interested in the observation that upon haematological perturbations a human-like clonal hematopoiesis can be triggered, which is otherwise absent.

#HemeSky

Outstanding contributions to our field and society acknowledged with this year’s ISEH awards. Presentations and award seminars at this year’s annual meeting in Kumamoto iseh.org/page/iseh2025

Actually, not so rare at all!

#RareDiseaseDay

Affecting a substantial part of human kind!

Support research on rare diseases!

Picture from rarediseaseday.org

YouTube video by MRC Weatherall Institute of Molecular Medicine Rare Disease Day 2025: Paediatric Leukaemias

To conclude our #RareDiseaseDay series, we spoke with @ellouka.bsky.social, a clinician scientist researching Paediatric Myelodysplastic Syndromes (MDS) and Juvenile Myelomonocytic Leukaemia (JMML). These are incredibly rare childhood cancers, with no current treatment options available. 🧪

Interesting, thank you!

🔥 New Fraticelli lab publication🔥

“Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations”

Now at Cell Stem Cell, with two new figures, in vivo, and sequential mutagenesis data.

Performed with the support of Cris Cancer and @erc.europa.eu

Fantastic achievement! Congratulations to all of you!

Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer - Nature Genetics Oncofetal (OnF) reprogramming, driven by YAP and AP-1, induces phenotypic plasticity and therapy resistance in WNT-dependent colorectal cancer (CRC). Targeting the OnF state in combination with chemot...

Very interesting!

How is this related to the role of AP-1 in oncofetal reprogramming, as recently published by @sleemmz.bsky.social et al. @naturegenet.bsky.social? Do you see such signatures, too? Are they dynamically regulated?

www.nature.com/articles/s41...

Great tool that seems to work well in our hands.

Congrats to Yunhee Jeong, @pavlolutsik.bsky.social and the entire team!

#InternationalChildhoodCancerDay

Support medical care and biomedical research for our vulnerable children worldwide!

#Science
#CancerResearch
#ChildhoodCancer
#OncoSky
#Kinderkrebstag

Stark!

Kommenden Donnerstag gibt’s noch eine Chance. Für alle, die schon da waren und besonders auch für diejenigen, die es am Mittwoch nicht geschafft haben!

Very interesting topic!

Reprogramming, plasticity, safeguards… exciting topic and fantastic story!

Great to see this out - Congratulations to all of you!

Must read!

#OncoSky

Cool cover for a fascinating story!

Will discuss it tomorrow in our Journal Club.