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Johan Ajnabi

@johanajnabi.bsky.social

Website: https://johanajnabi.github.io PhD Scholar | Institute for Stem Cell Science and Regenerative Medicine (inStem) Prof. Colin Jamora's Laboratory | SNIoE #CellBiology #Epigenetics #Mechanobiology #Skin #WoundHealing

25 Followers  |  204 Following  |  3 Posts  |  Joined: 16.01.2026  |  1.6571

Latest posts by johanajnabi.bsky.social on Bluesky

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Meet the one-eyed mechanobiology monster.
Turns out cells look terrifying when you zoom in far enough. 👾🔬

#microscopy #alien #monster #mechanobiology #CellBiology #confocal #imaging #immunofluorescence

03.02.2026 15:18 — 👍 2    🔁 0    💬 0    📌 0

Signaling depends not just on interactions, but on location. In our recent study led by @binitadam.bsky.social, we show that Mindin-αM integrin signaling requires trafficking to acidic early endosomes, where pH-driven integrin conformational changes enable STAT3 activation and stemness.
#signaling

03.02.2026 15:04 — 👍 1    🔁 1    💬 0    📌 0
Mindin regulates fibroblast subpopulations through distinct Src family kinases during fibrogenesis Fibrosis results from excessive extracellular matrix (ECM) deposition, which causes tissue stiffening and organ dysfunction. Activated fibroblasts, central to fibrosis, exhibit increased migration, proliferation, contraction, and ECM production. However, it remains unclear if the same fibroblast performs all of the processes that fall under the umbrella term of “activation.” Owing to fibroblast heterogeneity in connective tissues, subpopulations with specific functions may operate under distinct regulatory controls. Using a transgenic mouse model of skin fibrosis, we found that Mindin (also known as spondin-2), secreted by Snail-transgenic keratinocytes, differentially regulates fibroblast subpopulations. Mindin promotes migration and inflammatory gene expression in SCA1+ dermal fibroblasts via Fyn kinase. In contrast, it enhances contractility and collagen production in papillary CD26+ fibroblasts through c-Src signaling. Moreover, in the context of the fibrotic microenvironment of the tumor stroma, we found that differential responses of resident fibroblast subpopulations to Mindin extend to the generation of functionally heterogeneous cancer-associated fibroblasts. This study identifies Mindin as a key orchestrator of dermal fibroblast heterogeneity, reshaping cellular dynamics and signaling diversity in the complex landscapes of skin fibrosis and cancer.

Feed: "JCI Insight -- New Articles"
By: Sunny Kataria, Isha Rana, Krithika Badarinath, Rania F. Zaarour, Gaurav Kansagara, Sultan Ahmed, Abrar Rizvi, Dyuti Saha, Binita Dam, Abhik Dutta, Ravindra K. Zirmire, Edries Yousaf Hajam, Pankaj Kumar, Akash Gulyani, Colin Jamora

22.02.2025 17:34 — 👍 1    🔁 2    💬 0    📌 0

Behind-the-scenes: Dr. Dyuti Saha at the confocal microscope at the Core Imaging Facility in the Department of Life Sciences and Shiv Nadar University (an Institution of Eminence) capturing images of the vasculature in the fibrotic skin.

04.08.2025 14:40 — 👍 3    🔁 2    💬 0    📌 0
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ICYMI: Vasculopathy occurs early in systemic sclerosis, but intervention strategies are lacking.

Colin Jamora & team reveal ANGPTL2 as an inducer of vasculopathy that drives cutaneous fibrogenesis in mice—mirroring SSc—and present a therapeutic approach: UAS03.

buff.ly/xNYvnRj

10.08.2025 15:33 — 👍 1    🔁 2    💬 0    📌 0
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Vasculopathy occurs early in systemic sclerosis, but intervention strategies are lacking.

Colin Jamora & team reveal ANGPTL2 as an inducer of vasculopathy that drives cutaneous fibrogenesis in mice—mirroring SSc—and present a therapueutic approach: UAS03:
buff.ly/SpOiuCc

04.08.2025 13:20 — 👍 3    🔁 1    💬 0    📌 1

Actin-dependent mechanotransduction controls nucleocytoplasmic partitioning of DNMT3a through ERK1/2 signaling during cutaneous wound healing https://www.biorxiv.org/content/10.64898/2026.01.15.699481v1

16.01.2026 01:30 — 👍 1    🔁 2    💬 0    📌 0

How do mechanical cues at wounds reprogram skin cells?
Our new study shows that actin remodeling regulates ERK1/2 signaling to allow DNMT3a nuclear entry, linking mechanotransduction to epigenetic control in early wound healing.
#Mechanobiology #Epigenetics #WoundHealing #bioRxiv

16.01.2026 18:18 — 👍 5    🔁 1    💬 0    📌 0

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