Acta Materia Medica

Discovery of vina-ginsenoside R18 as a novel dual-target inhibitor of dengue virus envelope protein and RNA-dependent RNA polymerase Vina-ginsenoside R18, acts as the first dual inhibitor of dengue virus E protein and RdRp, blocking viral entry and replication effectively

This study identifies Vina-ginsenoside R18, a #triterpenoid #saponin from #PanaxNotoginseng, as the first dual inhibitor of DENV E protein and RdRp, blocking #ViralEntry and replication, and effectively suppressing #dengue infection in vitro & in vivo.

#OpenAccess: amm-journal.org/index.php/20...

Benzo-fused ten-membered ring meroterpenoids: sources, chemical diversity, biological activities, and biosynthesis Reviewing the sources, structural diversity, bioactivities, and biosynthetic pathways of benzo-fused ten-membered ring meroterpenoids.

A comprehensive overview of the sources, structural diversity, #bioactivities, and biosynthetic pathways of benzo-fused ten-membered ring #meroterpenoids reported between 1980 and 2024 highlighting their potential in next-generation drug development.

#OpenAccess: amm-journal.org/index.php/20...

Biologically Active Guanidine Alkaloids An overview of antimicrobial, antiparasitic, antiviral, and anticancer properties of bioactive guanidine alkaloids.

This review provides a detailed overview of the #antimicrobial, antiparasitic, antiviral, and #anticancer effects of various bioactive guanidine alkaloids isolated from different marine species.

#OpenAccess: amm-journal.org/index.php/20...

Innovations and challenges in bioresponsive materials for effective drug delivery in diabetes mellitus Reviewing the latest progress and challenges in bioresponsive materials and their application for effective drug delivery in diabetes mellitus.

This review provides an overview of the latest progress and challenges in #bioresponsive materials, and details the applications of different #biomaterials and their effective #DrugDelivery mechanisms in #DiabetesMellitus.

#OpenAccess: amm-journal.org/index.php/20...

Caryota maxima leaf extract extends Caenorhabditis elegans lifespan by inducing mono-unsaturated fatty acid accumulation via DAF-2 signaling Identification of a novel herbal extract and its active ingredient as a natural geroprotector with anti-aging effects

In this study, scientists discovered that #rutin, an active ingredient from the extract of #caryotamaxima leaves, possesses #geroprotective effects mediated by #LipidMetabolism regulation via DAF-2 downstream signaling pathways.

#OpenAccess: amm-journal.org/index.php/20...

Advances in gasdermin activation, regulation, and targeted drug development - AMM Journal Comprehesive outlook on Gasdermin

An overview on the structure, activation & downstream effects of #gasdermin with implications in various diseases and #targeteddrugdevelopment. #Pyroptosis, #DAMPs #GSDMoligomerization #GSDMDagonists #DrugDelivery

#OpenAccess: amm-journal.org/index.php/20...

Formulation approaches and strategies for transdermal delivery of insulin: special emphasis on microneedle-based systems <p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d1280308e163">The prevalence of diabetes is increasing and expected to become a major global health bu...

This article reviews the advancements and challenges in #transdermal #insulin delivery systems, with a special focus on #microneedle transdermal delivery, and discusses current limitations and future prospects.

#OpenAccess:
www.scienceopen.com/hosted-docum...

We’re proud to announce that @amm-journal.org has achieved an impressive #CiteScore of 8.1!

This places us 1st out of 33 journals in the field of #OccupationalTherapy.

A heartfelt thank you to our editorial team, authors, reviewers, and supportive readers.

#OpenAccess: amm-journal.org

Therapeutic strategies targeting SREBP transcription factors Mechanism of action underlying SREBP in different diseases and its targeted inhibition for disease prevention and treatment.

This review summarizes the recent findings of #SREBPs mainly in terms of physiologic activation processes, regulatory processes, related diseases, and publicly available #SmallMoleculeInhibitors with #therapeuticpotential.

#OpenAccess: amm-journal.org/index.php/20...

#medsky #medicalresearch

Catapol: a promising natural neuroprotective agent for neurologic disorders Neuroprotective mechanism of catalpol against various neurological disorders

Catalpol a natural neuroprotective agent may help treat neurologic disorders by reducing inflammation and stress.

amm-journal.org/index.php/20...

#CatalpolResearch #RehmanniaeRadixBenefits #NeurologicHealth #NeuroprotectionMechanisms #BrainSignalingPathways #NeurologicalDisorders

PROTACs improve selectivity for targeted proteins PROTACs offer a novel approach to degrade disease-causing proteins, showing promise in targeting cancers and drug-resistant proteins with high selectivity.

PROTACs are redefining drug discovery by enabling selective degradation of disease-driving proteins. From targeting the undruggable to overcoming resistance, PROTACs hold the key to next-gen precision therapies.

amm-journal.org/index.php/20...

#PROTAC #DrugDiscovery #TargetedTherapy #Biotech

Ferroptosis by nanomaterials: targeting cancer stem cells and overcoming drug resistance Ferroptosis-focused nanomaterials eradicate cancer stem cells and overcome drug resistance via iron-driven lipid peroxidation in precision oncology

Ferroptosis by nanomaterials: targeting cancer stem cells and overcoming drug resistance

amm-journal.org/index.php/20...

#Ferroptosis #drugresistance #cancerstemcell #nanomaterials

Revolutionizing HIV treatment: unveiling the new frontiers of HIV capsid research Revolutionizing HIV treatment with lenacapavir: first capsid inhibitor overcoming drug resistance, long-acting efficacy, 100% prophylaxis success.

Revolutionizing HIV treatment with lenacapavir: first capsid inhibitor overcoming drug resistance, long-acting efficacy, 100% prophylaxis success.

amm-journal.org/index.php/20...

#HIV1CapsidProtein #Lenacapavir #NuclearPoreComplex #NuclearTranslocation #DrugDesign #HIVtreatment

Discovery of wedelolactone from Eclipta Prostrata (L.) Linn. as a natural PDE4 inhibitor with potent anti-psoriasis effects Discover Wedelolactone (WDL), a natural PDE4 inhibitor from Eclipta prostrata. Safe, effective topical psoriasis therapy with clinical potential.

Discover Wedelolactone (WDL), a natural PDE4 inhibitor from Eclipta prostrata. Safe, effective topical psoriasis therapy with clinical potential.

amm-journal.org/index.php/20...

#Ecliptaprostrata #Wedelolactone #Phosphodiesterase4inhibitor #Psoriasis #Moleculardynamicssimulation

Moracin M derivative targeting PDE4 for the treatment of psoriasis LW, a Moracin M derivative, inhibits Phosphodiesterase-4 (PDE4), reduces inflammation, and improves psoriasis symptoms, showing strong therapeutic potential with fewer side effects.

LW, a #MoracinM derivative, inhibits #PDE4, reduces inflammation, and improves psoriasis symptoms, showing strong therapeutic potential with fewer side effects.

Read More: tinyurl.com/3pvwextj

#PDE4inhibitor #psoriasis #inflammatoryfactor #AMMJournal @scienceopen.bsky.social

Berberine inhibits phagocytosis through the TLR4-PI3K-CDC42 pathway Berberine inhibits phagocytosis and inflammation via the TLR4-PI3K-CDC42 pathway, suppressing NF-κB signaling and key inflammatory markers in macrophages.

Berberine (BBR) inhibits phagocytosis and inflammation via the TLR4-PI3K-CDC42 pathway, suppressing NF-κB signaling and key inflammatory markers in #macrophages.

Read More: tinyurl.com/4ktmt2pd

#Berberine #Phagocytosis #TLR4-PI3K-CDC42 #AMMJournal @scienceopen.bsky.social

Natural supramolecular photosensitizer with in situ switchable photothermal/photodynamic effects as an imaging platform for precise and controlled cancer synergistic therapy A nanoplatform with Supramolecular photosensitizer and metal ions enables tumor imaging and multimodal therapy, achieving complete tumor elimination in preclinical studies.

A nanoplatform with photosensitizers and metal ions enables tumor imaging and multimodal therapy, achieving complete tumor elimination in preclinical studies.

Read More: amm-journal.org/index.php/20...

#Supramolecularphotosensitizer #cancertherapy @scienceopen.bsky.social

We would like to thank the reviewers who contributed to Acta Materia Medica Volume 3 (2024). Your efforts play a vital role in maintaining the quality of our journal. See the full list of reviewers here: amm-journal.org/index.php/ac...

#ThankYouReviewers #PeerReview #AcademicPublishing

Coumarin derivatives as inhibitors against monoamine oxidase: structure-activity relationships and inhibitory mechanisms Explore the structure-activity relationships and inhibitory mechanisms of coumarin derivatives as inhibitors against monoamine oxidase (MAO). Learn about their potential applications in neuropharmacol...

Explore coumarin derivatives as potential drugs! Learn about their inhibitory mechanisms against monoamine oxidase. #DrugDiscovery #MAOInhibitors

Read More: amm-journal.org/index.php/20...

#Enzymeinhibition #Drugdiscovery #Neuropharmacology #Medicinalchemistry @scienceopen.bsky.social

Randomized, waitlist-controlled trial of Cordyceps sinensis mycelium culture extract (Cs4) for long COVID patients in Hong Kong Cordyceps sinensis mycelium culture extract (Cs4) were assessed for alleviating long COVID symptoms. In this randomized trial 110 participants were assigned to receive Cs4 (55 participants) or were wa...

Randomized, waitlist-controlled trial of #Cordycepssinensis mycelium culture extract (#Cs4) for #longCOVID patients in Hong Kong.

Read More: amm-journal.org/index.php/20...

#randomizedtrial #modifiedCOVID19 #YorkshireRehabilitationScale #C19YRSm @scienceopen.bsky.social

EGCG inhibits ferroptosis to ameliorate APAP-induced liver injury by suppressing NEDD8 and stabilizing HUWE1 in vivo and in vitro - AMM Journal EGCG stabilizes HUWE1 and degrades TFR1 to suppress ferroptosis, mitigating APAP-induced liver injury. Discover novel DILI treatment insights for researchers.

New study alert! EGCG mitigates acetaminophen-induced liver injury by stabilizing HUWE1 and suppressing ferroptosis. Discover innovative DILI therapies: amm-journal.org/index.php/20...

#LiverResearch #EGCG #DILI #Ferroptosis #BiomedicalResearch

Pathologic and therapeutic insights into cholestatic liver disease-associated depressive disorder Uncover neuroendocrine links in cholestasis-induced depression: bile acid accumulation disrupts the BBB and gut-brain axis, revealing new therapeutic targets.

New review: How does cholestasis trigger depression? Discover how bile acids disrupt the BBB, drive neuroinflammation, and affect the gut-brain axis. Learn more: amm-journal.org/index.php/20...

#Cholestasis #DepressionResearch #Neuroendocrine #GutBrainAxis #LiverDisease

Exploring food and medicine homology: potential implications for cancer treatment innovations Food and medicine homology (FMH) offers a promising approach to cancer treatment, combining nutrition and pharmacology for low-toxicity, effective therapies.

Exploring food and medicine homology for innovative cancer treatments! FMH bridges nutrition & pharmacology, offering low-toxicity, patient-friendly therapies. A game-changer in oncology!

Read more: amm-journal.org/index.php/20...

#cancerresearch #foodasmedicine #FMH #oncology #integrativemedicine

Antineoplastic effects of icaritin: molecular mechanisms and applications Antineoplastic effects of Icaritin acting through various molecular mechanisms. Its potential applications in cancer therapy continue to expand.

Antineoplastic effects of #Icaritin acting through various molecular mechanisms. Its potential applications in #cancertherapy continue to expand.

Read More: tinyurl.com/2e67ex3e

#traditionalChinesemedicine #hepatocellularcarcinoma #molecularmechanism #ammjournal @scienceopen.bsky.social

Progress in the structural modification and pharmacological activity of isosteviol Isosteviol and its derivatives, diterpene compounds with a wide range of biological activities, play important antiviral, antibacterial, antioxidant, antitumor, analgesic, anti-inflammatory, antipyret...

Exploring the #pharmacologicalactivity of #isosteviol! From antiviral to anti-inflammatory benefits, its potential in drug discovery is immense. Stay tuned for breakthroughs in medicinal chemistry.

Read More: tinyurl.com/5bzv345u

#Isosteviol #Diterpene #ammjournal @scienceopen.bsky.social

Deciphering the regulatory programs of RNA binding proteins in rheumatoid arthritis through single-cell transcriptome analysis Single-cell RNA-seq reveals RNA binding proteins dysregulation in RA vs OA, altering splicing & signaling; new therapeutic targets emerge! right now!!

#SinglecellRNA-seq reveals #RNA binding proteins dysregulation in RA vs OA, altering splicing & signaling; new therapeutic targets emerge! right now!!

Read More: tinyurl.com/ycj5b6m9

#scRNAseq #rheumatoidarthritis #celltocellcommunication #fibroblasts #ammjournal @scienceopen.bsky.social

MiR-128-3p mediates MRP2 internalization in estrogen-induced cholestasis through targeting PDZK1 miR-128-3p promotes MRP2 internalization by inhibiting PDZK1, contributing to estrogen-induced cholestasis. Restoring PDZK1 may offer therapeutic potential.

#miR1283p promotes #MRP2 internalization by inhibiting #PDZK1, contributing to #estrogeninducedcholestasis. Restoring PDZK1 may offer therapeutic potential.

Read More: tinyurl.com/yc6wf3kd

#localization #ammjournal @scienceopen.bsky.social

PROTAC technology for prostate cancer treatment Explore key biomarkers and novel therapies for prostate cancer treatment, including PROTAC technology, offering hope for overcoming castration-resistant PrCa.

Explore key biomarkers and novel therapies for #prostatecancer, including #PROTAC technology, offering hope for overcoming castration-resistant #PrCa.

Read More: tinyurl.com/2mnpwec5

#ProstateCancerTreatment #chemicalbiology #cancerbiology #prostatecancer @scienceopen.bsky.social

Machine learning-powered, high-affinity modification strategies for aptamers Explore machine learning strategies for aptamer modification that boost binding affinity 105-fold and enhance Wnt signaling for improved bone regeneration.

Discover how #machinelearning enhances #aptamermodification, achieving a 105-fold #higheraffinity and #boostingWntsignaling for advanced #biosensing and #therapy.

Read More: tinyurl.com/eunf3juu

#PostSELEX #Sclerostin @scienceopen.bsky.social

Arenobufagin suppresses the progression of early-stage hepatocellular carcinoma by inhibiting EpCAM-mediated tumor stemness EpCAM promotes cancer stemness and early-stage HCC progression, counteracted by arenobufagin, a potential therapeutic targeting EpCAM.

#EpCAM promotes #cancerstemness and #earlystageHCCprogression, counteracted by #arenobufagin, a potential therapeutic targeting EpCAM.

Read More: amm-journal.org/index.php/20...

#Epithelialcelladhesionmolecule @scienceopen.bsky.social