Joan Chang

📣Wondering what to expect from our next annual meeting? Planning your journey? Our preliminary program is now live! Don't forget to submit your abstracts!!! #matrixbiology @dsmb-dk.bsky.social @mbsanz.bsky.social @amsocmatbio.bsky.social @themeshwork.bsky.social
www.matrixbiologie.de/annual-meeti...

Had a wonderful time as usual! Really fantastic to see so many new #ECMatrix young scientists from diverse institutions, with exciting projects 💪🏻 and superb hosting (and organisation) from @ccstorytime.bsky.social of course (should've taken more food photos)!

📢 2 very exciting PhD opportunities, please share!

We use a range of technologies+systems to study #collagen, #ECMatrix, and #fibrosis 👇

1) MRC CASE DTP - #3D #biomaterials, #immune cells alter, #drugscreens
lnkd.in/e6eMqs8M

2) Bicentenary - #macrophages, #circadian, #omics.

lnkd.in/ekZfJfsd

My office for the next week or so, good to be back at HKU.

Looking for a PhD ? Don’t miss ⬇️
12 PhDs available in the REMOD-HEALING European doctoral network, funded by Horizon Europe's MCSA-DN program, in Europe and Costa Rica !
www.euraxess.fr/jobs/375945
@themeshwork.bsky.social @matrixbiologie.bsky.social
#ECM #collagen #WoundHealing
#proteases

Is research culture really too hard to assess? Yolana Pringle and Ben Tatler make the case that the REF pause should be the moment to build on the most substantial sector-wide collaboration ever undertaken on research environments

Thoughtful (and hopeful) reflections on the state-of-play for #ResearchCulture assessment as part of #REF2029 and the #REFPCE indicators project:

wonkhe.com/blogs/is-res...

"We don’t need all the answers for 2029, but we shouldn’t discard the tangible progress made"

Become part of our new MRC Centre, working across Manchester and Oxford to solve a major challenge of our time - how does the immune system become dysregulated by environmental exposures to cause chronic disease.
www.manchester.ac.uk/exposome-jobs
@exposomeimmunology.bsky.social

Model describing how daily rhythmic O-GlcNAc proteome integrates environmental and metabolic signals to regulate transcriptomic and physiological rhythms. Environmental cues signaling through the molecular clock and metabolic cues from feeding–fasting cycles regulate daily rhythms in the O-GlcNAc proteome. Rhythmic O-GlcNAcylation can directly shape daily rhythmicity in transcriptome and physiology. In addition, rhythmic O-GlcNAcylation can also interact with rhythmic phosphorylation. Different forms of crosstalk between O-GlcNAc proteome and phosphoproteome are shown in the middle box. The red solid arrows indicate the regulations described in this study, while the dashed arrow indicates regulations discovered by previous studies. Figure created using BioRender.com.

The liver #transcriptome is highly sensitive to metabolic cues. By characterizing nuclear protein #OGlcNAcylation in mouse #liver during the day, @joanna-chiu.bsky.social &co show how shifts in a nutrient-sensitive #PTM may shape transcriptional regulation @plosbiology.org 🧪 plos.io/3KuS7m1

Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.

New review! Towards a unified framework for the function of ER exit sites

www.nature.com/articles/s41...

🎉 Happy Postdoc Appreciation Week 2025! 🎉

At ASMB, we’re celebrating the innovators of tomorrow — our incredible PhD students & postdocs who are driving discovery every day.

👉ASMB members, want to be featured?: We are still accepting Submissions!

#ASMBPAW2025 #ASMBTrainees #ECMatrix

It's been a great conference hearing all the other research findings and lots of new ideas - food for thought for everyone! Wish I didn't have to leave earlier...

Great to meet with @tranejoan.bsky.social

Awesome talk (as expected) by @stockmannlab.bsky.social on targeting fibrogenesis, at the #SclerodermaWorkshop - first reunion since #KeystoneFobrosis2022!

Yesterday I attended the #graduation of my #firstPhD student Katie Lowles. What a moment! No longer her PI but still feeling very proud @mcf-uom.bsky.social @mcrcellmatrix.bsky.social

(Oh and I also attended my first ever #GRCCollagen...it was awesome even though I had to leave early!)

Our final online seminar of the season is just around the corner!!! Save the date: June 25, 3pm CET. Register for FREE now and join us next week to discuss all things Hyaluronan in Medicine with Dr Laura Alaniz!!! Follow the QR code or click here: forms.gle/iSjnrLBVZmkD... @amsocmatbio.bsky.social

📢 IMPORTANT DATE ALLERT!
Excited for the ASMB 2025 Biennial Meeting in Baltimore, Nov 16–19! Early Bird Registrations and Abstract submission deadline approaching—Don't forget to sign up first, then submit your abstract. See you there!
#ASMB2025 #ASMBaltimore2025 #ECMatrix

Looking forwards to talking about #collagen and #circadian (or otherwise!) tomorrow!

Not sure I'm the expert, but definitely we're all about the #ECMatrix with a dabble of #CircadianRhythms 😆

Are you into cryo-ET, in-cell discovery, protein translocation and folding or just cool integration of structural biology, proteomics and bioinformatics? Then see our new work:

www.biorxiv.org/content/10.1...

Thank you to all coauthors for your amazing work!

Sad that there's no polls option on Bluesky!

I think mine would be Dramedy...

It's starting! #BSMB2025 with a very international delegate pool #ECMatrix #ScienceNoBoundaries

So professional (until it got to my part, so flustered!) - it's been a wonderful meeting and it's exciting to see a YouTube channel!! #ECMatrix #ScienceNoBoundaries

Biologist whose innovation saved the life of British teenager wins $3m Breakthrough prize Prof David Liu is among the winners of 2025’s ‘Oscars of science’, with honours also going to researchers for landmark work on multiple sclerosis, particle physics and ‘skinny jabs’

Incredible.

"David Liu – a professor at the Broad Institute of MIT and Harvard, a biomedical research facility in Massachusetts – has marked Thanksgiving by handing over his entire annual salary to the staff and students in his laboratory."

www.theguardian.com/science/2025...

Join us 3/26!
#MeetTheSpeaker #2: Dr. Simona Plesselova (@simastatina), postdoc in @delapuente_lab who will share here latest work on Targeting #ECM to Reprogram Hypoxic Immunologically Cold #OvarianTumor

Info & registration: asmb.net/e-symposia #ECMatrixIsEverywhere #WomensHealth

Don't forget to join our next #eSymposium organized by @delapuente_lab & @GonzalezPLab on the Intersection of Women’s Health & the ECM.

#MeetTheSpeaker: Brandon J Vogt (www.linkedin.com/in/brandon-vogt-1028/)

Info & registration: www.asmb.net/e-symposia

#ECMatrixIsEverywhere #WomensHealth

We're ready for #BritishScienceWeek @ManchesterMuseum! All about #secretion, #ECMatrix assembly, from cells to #zebrafish! @mcrcellmatrix.bsky.social @mcf-uom.bsky.social

Standing in spirit with my US colleagues 💪🏻 #ScienceNoBoundaries #ECMatrix

Macrophages promote collagen deposition through circadian regulation of fibroblasts Collagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another i...

Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out 👇🏻

#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social

www.biorxiv.org/content/10.1...

We #ASMB stand up for #science on March 7 2025 - Because science is for and impacts everyone!

Find your local rally site and other ways to get involve here: standupforscience2025.org

#ECMatrixIsEverywhere #StandUpForScience2025 #ScienceNotSilence #ScienceForAll

We are #celebrating #BlackHistoryMonth by highlighting some of our members! New entries are still welcomed, so keep them coming!