Misha Zilberter

Place cells in CA1 lack topographical organization of firing locations | PNAS Topography is a well-described and well-known concept for cortical organization in primary sensory and motor cortices of mammalian brains. Similar ...

A half-century old question may have its final answer. Using high-resolution #Mini2P microscopes, we find no evidence of local topography in #PlaceCells. Place fields of neighbouring cells are no more similar than those of randomly selected cells. 🧠🗺️ Out now in @pnas.org www.pnas.org/doi/10.1073/...

a man with glasses and a mustache is wearing a white shirt and says yes . ALT: a man with glasses and a mustache is wearing a white shirt and says yes .

Love the smell of a paper acceptance email in the morning

Deletion of neuronal Idol ameliorates Alzheimer's disease–related pathologies via APOE receptors INTRODUCTION Overexpression of the low-density lipoprotein receptor (LDLR) is known to decrease apolipoprotein E (APOE) levels and alleviate amyloid beta (Aβ) pathology. We hypothesized that inhibit...

Congrats @handekarahan.bsky.social & our team members!
A potential new drug target for Alzheimer's disease.
Targeting the APOE pathway more effectively.
Might also enhance neuroprotective pathways, offering resilience against disease progression.
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Please share: I am recruiting a PhD student to join my lab in Oslo!

For this project, we will investigate the role of striatal interneurons during action selection, using a combination of behavior, in vivo voltage imaging, and slice ephys.

www.jobbnorge.no/en/available...

#NeuroJobs #NeuroSkyence

🔵mTurquoise2-based glucose biosensors TINGL and THINGL from @joachimgoedhart.bsky.social and the Teusink Lab!
Find the plasmids here: www.addgene.org/browse/artic...

How does neuronal gene expression evolve over time in response to experience? CytoTape will help us find out - a major milestone for neuroscience, providing new ways to study memory & aging 🧠

Congrats to the whole team! Looking forward to our continued collaboration on this work 🎉

The Pearson lab is looking for an enthusiastic research technician to join our team! Come join us in New York City! 🍎🧪
jobs.weill.cornell.edu/NY/job/New-Y...

#science #neurobiology #devbio

Excited to share newly minted PhD Anu Korukonda's tour de force thesis work describing the impact of pathogenic tau on #locuscoeruleus function in a mouse model of early #Alzheimers. A must for #BlueSpot researchers! www.biorxiv.org/content/10.6...

1/3

Because of technical issues with the SciENcv website, NIH is extending a period of leniency accepting old format biosketches through May 2026 (see FAQ #5):

grants.nih.gov/faqs#/common...

Our paper is (finally) out in Cell today!

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
www.cell.com/cell/fulltex...

Great collaborative effort - read more from first author @asamelson.bsky.social below:

Tau pathology reprograms glucose metabolism to support cortical hyperexcitability, excitatory/inhibitory imbalance, and sleep loss npj Dementia - Tau pathology reprograms glucose metabolism to support cortical hyperexcitability, excitatory/inhibitory imbalance, and sleep loss

New work from our lab! Link: rdcu.be/e0sfU

𝗧𝗮𝘂 𝗛𝗶𝗷𝗮𝗰𝗸𝘀 𝗕𝗿𝗮𝗶𝗻 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺, 𝗗𝗿𝗶𝘃𝗶𝗻𝗴 𝗦𝗹𝗲𝗲𝗽 𝗟𝗼𝘀𝘀 𝗶𝗻 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲

A quick thread on our findings!

Super interesting work – congratulations Shannon and team! Will make sure my lab reads this, very relevant to our projects.

Excited to be on the organization meeting for the 6th annual NCM conference on Neural Circuits in Health & Disease. Terrific line up of speakers!

Hi ephys enthusiasts! We have available slots for speakers for the King's Ephys Club editions in March, April and May. We usually run these on the last Thursday of the month at 16:30 at KCL (but no need to be from KCL!).

Drop me an email if you're interested at ana.dorrego-rivas[at]kcl.ac.uk

Out now!!
www.nature.com/articles/s44...

Intro to this paper pictured below

Huge thanks to collaborators @neilmdavies.bsky.social, @emmylooroll.bsky.social at @uclbrainscience.bsky.social & Sami Heikkinen and Mikko Hiltunen at @uniuef.bsky.social ...

#endalz #episky #medsky

Happy to announce the 2nd Hippocampus Green Meeting
📍 Barcelona, Spain
🗓️ May 11–12, 2026
Organized together with Manu Valero, Lisa Roux and Dan Bendor
🎤 Keynotes: Nachum Ulanovsky & György Buzsáki
‼️ Call for abstracts now open
🔗 hippocampusgreen.net/wp/
#HippocampusGreen

Neuronal APOE4 reduction with an APOE-I3-targeting ASO protects against neurodegeneration and neuroinflammation in an Alzheimer's disease mouse model https://www.biorxiv.org/content/10.64898/2025.12.10.693468v1

Cracking open a celebratory bottle of brandy with our first author, Dennis, to mark the paper’s acceptance. Moments like this make it all worth it.

Neuronal APOE4 drives damaging lipid accumulation via contact-dependent neuron-oligodendrocyte-microglia interaction in Alzheimer's disease https://www.biorxiv.org/content/10.64898/2025.12.04.692390v1

Reviewers in December

How cool is this new work from the Bienkowski lab?
CA1 of mouse hippocampus has 4 layers of specialized cell types. "This...changes our understanding of how information is processed...and could explain why certain cells are more vulnerable in diseases like Alzheimer’s and epilepsy."
Read more ⬇️

Another great preprint on neuronal APOE4 from the Huang lab!

The Energetic Collapse of the Alzheimer's Brain: Metabolic Inflexibility Across Cells and Networks Metabolic inflexibility in Alzheimer's disease. Schematic illustrating the biphasic trajectory of metabolic activity relative to canonical Alzheimer's disease (AD) biomarkers. In the presymptomatic p...

Our new review is out today!

𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀

We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.

onlinelibrary.wiley.com/doi/10.1111/...

My study section (orig. scheduled for today) is back in EDIT phase...luckily, critiques are still there.

Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes INTRODUCTION The ε4 allele of the apolipoprotein E (APOE) gene is a risk factor for the development of Alzheimer's disease (AD). APOE4 isoform is associated with increased white matter lesions in hu.....

Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes - Al‐Amin - 2025 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

ZRG1 BN-F (92) S originally scheduled for Nov12-13 has been cancelled (to be rescheduled ofc)

Mitochondrial bioenergetic signatures differentiate asymptomatic from symptomatic Alzheimer’s disease Asymptomatic Alzheimer’s disease (AsymAD) refers to individuals who, despite exhibiting amyloid-β plaques and tau pathology comparable to Alzheimer’s disease (AD), maintain cognitive performance simil...

Mitochondrial bioenergetic signatures differentiate asymptomatic from symptomatic Alzheimer’s disease: www.biorxiv.org/content/10.1...

⚠️SAVE THE DATE⚠️

🧠CAJAL CONFERENCE 2026 
📍Cádiz, April 15–17

“Novel Insights into Brain Energy Metabolism in Health and Disease”

Join an outstanding lineup of keynote speakers!👇🏻