Misha Zilberter

Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance Alzheimer's disease (AD) is not only characterized by amyloid-beta (Aβ) and tau pathology, but also by early and progressive disruptions in metabolism. Neuronal excitability is tightly coupled with me...

🔥New preprint from the lab! Led by @rileyirmen.bsky.social

Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance

📍 biorxiv.org/content/10.1101/2025.07.25.666872v1

🧵 on how tau disrupts the metabolism–excitability balance in Alzheimer’s disease

Super interesting work Shannon - looking forward to discussing in person soon!

The NIH budget will INCREASE by $400 million — not slashed by 40%, as Trump proposed — according to a proposal by Senate appropriators, says Sen Murray.

"Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.

Glycogen supports glycolytic plasticity in neurons | PNAS Glycogen is the largest energy reserve in the brain, but the specific role of glycogen in supporting neuronal energy metabolism in vivo is not well...

C.Elegans neurons use glycogen to sustain synaptic function in times of energy stress: Glycogen supports glycolytic plasticity in neurons | PNAS www.pnas.org/doi/10.1073/...

For #AAIC2025 attendees: #ADRD researcher starter pack! Thanks @tyk314.net for promoting me to share this again

go.bsky.app/22DpUEy

Looking for a postdoc or staff scientist with brain slice electrophysiology experience. If you or someone you know is interested in, message me.

Cell-type-directed network-correcting combination therapy for Alzheimer’s disease A multi-cell-type drug discovery strategy targeting dysregulated gene networks in neurons and glia identified letrozole and irinotecan as a combination therapy that significantly improved memory and r...

amazing new discovery by my @gladstoneinst.bsky.social and @ucsanfrancisco.bsky.social colleagues, on cell-directed combination therapy for Alzheimer's disease. Although having seen first-hand what irinotecan does, I wouldn't recommend it. Proof of principle impressive. www.cell.com/cell/fulltex...

High‐frequency oscillations >250 Hz in people with Down syndrome and associated Alzheimer's disease dementia INTRODUCTION Alzheimer's disease (AD) dementia has near full penetrance in adults with Down syndrome (DS) and is strongly linked to late-onset myoclonic epilepsy in Down syndrome (LOMEDS). However, ...

Exited to share our new work! We found scalp high frequency oscillations (HFOs) in adults with Down syndrome, before the clinical onset of Alzheimer’s dementia and late onset myoclonic epilepsy.
HFOs may hold the key to earlier diagnosis #HFOnews
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Intracellular metabolic gradients dictate dependence on exogenous pyruvate - Nature Metabolism Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a key metabolite in central carbon metabolism.

RESEARCH | B Jackson, @lydiafinley.bsky.social‬
@mskcancercenter.bsky.social‬

Metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrients
🧪
https://bit.ly/4nWqEsH ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab

Congratulations Tal, that's a huge relief!

a man with a mustache is sitting on a swing in a park ALT: a man with a mustache is sitting on a swing in a park

54 days and counting on re-submission reviews... also celebrating the one-year anniversary of our initial submission.

I feel seen

Fuelling synapses via lipid metabolism Nature Metabolism, Published online: 01 July 2025; doi:10.1038/s42255-025-01306-wSynapses have long been thought to rely exclusively on glucose metabolism for energy. In this issue of Nature Metabolism, Kumar et al. reveal that synapses can tap into fatty acid metabolism to fuel ATP production and maintain synaptic activity when glucose is limited.

ICYMI:

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…

🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...

Awesome! Look forward to finally meeting in person and talking HFOs!

Kicking off the inaugural GRC Alzheimer’s disease meeting — excited for the science and the discussions ahead!

"But I am blown away by how much we have learned about Alzheimer’s over the last couple of years."—Bill Gates
www.statnews.com/2025/06/17/b...
"This is the moment to spend more money on research, not less."
Agree 💯
erictopol.substack.com/p/predicting...
erictopol.substack.com/p/the-breakt...

BREAKING: A federal judge in Massachusetts (the Reagan-appointed William Young) has declared the Trump administration's cuts to NIH grants — ostensibly over Trump's EOs on gender ideology and DEI — are "illegal" and "void." He's ordering many grants restored.

Brightly labelled pyramidal cells in the mouse retrosplenial cortex. Blood vessels are visible of various thicknesses in darker colours.

#neuroskyence folks: as my postdoc grant is running out soon, I am looking for new opportunities in systems neuroscience!

Keywords: patch clamp ephys, opto, mouse behavior, (in vivo) voltage imaging. Would love to return to the Basal Ganglia.

Sharing appreciated, and happy #FluorescenceFriday !

What's an acceptable (non-crazy) number of times to refresh a journal's manuscript tracking page while waiting for reviewer comments on a resubmission? Asking for a friend.

Don’t miss our latest 📝 with @chrislisgaras.bsky.social & Rick Staba on high-frequency oscillations in preclinical 🧠 disease models, with guidelines for recording, detection and analysis. journals.sagepub.com/doi/10.1177/...

Announcing an official fundraising campaign to support my lab’s research on APOE4 and Alzheimer’s disease: joinus.cuimc.columbia.edu/participant/.... This campaign is itself an experiment of sorts. But mostly, it's an attempt to save my lab during an unprecedented time of turmoil in academia. 1/9

Early neuronal reprogramming and cell cycle reentry shape Alzheimer's disease progression https://www.biorxiv.org/content/10.1101/2025.06.04.653670v1

Are you looking for a faculty job? We are hiring in my department at Roswell Park NOW. Contact me for details as I await the formal ad. (Please RT.)

APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses Excess lipid droplet (LD) accumulation is implicated in various diseases, including Alzheimer's disease (AD), yet the mechanisms underlying this accum…

What does the APOE 'lipid droplet-ome' look like???

Check out our new paper to find out!
www.sciencedirect.com/science/arti...

Thanks to first authors @cassifriday.bsky.social and @iostephens.bsky.social

+help from Scott Gordon @morganti.bsky.social and @cohenlaboratory.bsky.social labs

Blood-brain barrier permeability varies by brain region and APOE4 status and correlates with brain microstructure among high-AD risk groups Although strong evidence exists for blood–brain barrier (BBB) disruption in Alzheimer’s disease (AD), substantial uncertainty remains regarding its ro…

New work from our postdoc Seraphina Solders shows patterns of blood-brain barrier leakage in cognitively normal APOE4 carriers. BBB breakdown correlated with microstructural brain injury only in groups with high Alzheimer's disease risk (APOE4+, amyloid+, women) www.sciencedirect.com/science/arti...

Should mention that we are fortunate to have funding to support him, but thinking of all the other bright scientists who are not so lucky. No words…

A brilliant postdoc in my lab just received a final termination notice from NIA on his MOSAIC F32. He got an impact score of 20. Absolutely devastating.

Finally registered—looking forward to the inaugural Gordon Research Conference on Alzheimer’s Disease next month. Excited to connect with old and new friends in the AD field!

How does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cells in your brain 🧠🧬

New paper out in @natcomms.nature.com today: www.nature.com/articles/s41...

@ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social