DyNaMo lab

Multivalent Interactions between Chaperone and Ribosome-Nascent Chain Complex Revealed by High-Speed AFM and MD Simulations Trigger Factor (TF) is a primary ATP-independent molecular chaperone in bacteria that engages nascent polypeptide chains emerging from the ribosomal exit tunnel to assist their folding. However, the r...

Our new work is out!
HS-AFM × MD -->> new insights into multivalent TF–ribosome interactions.
pubs.acs.org/doi/10.1021/...

Multivalent Interactions between Chaperone and Ribosome-Nascent Chain Complex Revealed by High-Speed AFM and MD Simulations Trigger Factor (TF) is a primary ATP-independent molecular chaperone in bacteria that engages nascent polypeptide chains emerging from the ribosomal exit tunnel to assist their folding. However, the r...

Happy to announce that the work is now published and openly available in ACS Nano! Congratulations!
pubs.acs.org/doi/10.1021/...
@insermpacacorse.bsky.social @univ-amu.fr

YouTube video by GDR Imabio - CNRS Felix RICO : mechanical mapping by atomic force microscopy. From cells and tissues.

👉 Answer :

🔬 #Mifobio2025

@felixrico.bsky.social's lecture is online !

🎤 "Mechanical mapping by atomic force microscopy. From cells and tissues"

📹 👉 youtu.be/4X8LiAKMsKg

@univ-amu.fr @inserm.fr @dynamo-lab.bsky.social

#AtomicForceMicroscopy

Journal of Biosciences

🦠 A new study reveals how poroelasticity—fluid flow through interstitial spaces—bridges tissue architecture and mechanics, offering new insight into organ behavior and disease progression. 🔗 Journal of Biosciences: bit.ly/3WJWsF1. @yogiboi.bsky.social @felixrico.bsky.social

Happy to share our commentary "Length and time scales bridge poroelasticity and tissue architecture" in collaboration with Ramray Bhat from IISC Bangalore
rdcu.be/eMJp1
@yogiboi.bsky.social @dynamo-lab.bsky.social

Merci Les Petits Debrouillards!

@yfok.bsky.social @yogiboi.bsky.social ). @insermpacacorse.bsky.social

DyNaMo was at the Fête de la Science this October... Thanks to all the participants ( @ismahene-mes.bsky.social @yfok.bsky.social @yogiboi.bsky.social ). @insermpacacorse.bsky.social #FDSSUD #FDS2025

Demain, la Cellule de Culture Scientifique @univ-amu.fr organise "Recherche dans la ville" et DyNaMo y sera présent. Venez nombreux·ses !

Plus d'informations : www.univ-amu.fr/fr/public/ac...

Near equilibrium unbinding of streptavidin/biotin using single molecule acoustic force spectroscopy The dissociation of the streptavidin-biotin (SA-b) bond has been widely characterized using bulk and single molecule force spectroscopy (SMFS) techniques. However, the dissociation rates ( k off) from...

The curious case of streptavidin–biotin: a non-covalent bond.
Single Molecule Force Spectroscopy: “SA-b bond breaks in 1s at equilibrium”
SA-b at equilibrium: “Not really, More like 1-10 Days.”
(Answer: nobody—we were just pulling way too fast (far from equilibrium))
www.biorxiv.org/content/10.1...

Now we have it in 3D 🤓 which is fantastic! Thank you @yfok.bsky.social !

We first had a dynamic logo for @dynamo-lab.bsky.social that was quite cool...

Beautiful work led by Eider Nuñez combining high-speed AFM and MD simulations @dynamo-lab.bsky.social, Biofisika Institute and Donostia International Physics Center

Modulation of SARS-CoV-2 spike binding to ACE2 through conformational selection Nature Nanotechnology - This work uses single-molecule techniques to show that conformational changes of the spike protein of SARS-CoV-2 modulate binding to its human receptor. The study provides...

Our work on Modulation of SARS-CoV-2 spike binding to ACE2 through conformational selection is finally out rdcu.be/eqjgb . Work led by Prithwidip Saha, Claire Valotteau, Fidan Sumbul and Ignacio Fernandez. Thank you for 5 years of work @virusfusion007.bsky.social @trs90.bsky.social Charlie Gosse

Looking forward! We are waiting for you!

Laia Pasquina @laia-pasquina.bsky.social presents impressive quantitative analysis on the cell wall of bacteria with high resolution AFM. ImageJ plugin included github.com/Laia-Pasquin...

Yogesh Saravanan presents part of his PhD work on viscoelasticity of isolated and clusters of circulating tumour cells #afmbiomed @dynamo-lab.bsky.social

Lorena @lorenaredondo.bsky.social presenting her last results on nanomechanics of lipid membranes #afmbiomed @dynamo-lab.bsky.social

Ignacio Casuso revealing how regions of increased fluidity emerge in bacterial membranes #afmbiomed @dynamo-lab.bsky.social

Filomena Carvalho and Andra Dumitru open the day revealing mechanical changes of cells and tissues in diseases (restenosis and diabetes) #AFMbIoMed @andradumitru.bsky.social

Fernando Moreno-Herrero revealing the structural flexibility of RNA
Sourav Maity explores the mechanism of action of antibiotics in real time
#AFMBioMed

This week we're at the AFM BioMed conference at the University of Barcelona! Kicking things off with an exciting workshop by @brukercorporation.bsky.social — looking forward to a week full of nano-scale insights and great science. #AFMBioMed #Barcelona #Bruker #AFM

We continue with JL Pellequer on plant mechanics and how established assumptions are not always right #AFMBioMed

Kanaoka Kui uses HS-AFM to show the dynamics of P-gkycopriteins on nanodiscs #AFMBioMed

Eider Nuñez Viadero presents her beautiful HS-AFM movies of full ribosomes interacting with the trigger factor @dynamo-lab.bsky.social @biofisikaScienc #AFMBioMed

Lorenzo Villanueva @dynamo-lab.bsky.social presents his last algorithms for high-speed mapping of large biological samples #AFMBioMed

Looking for insights into mechanical proteins? Check out MechanoProDB, a database with force spectroscopy data, structural and functional info. Discover manual annotations of unfolding pathways and the regions involved. Explore now!
mechanoprodb.ibdm.univ-amu.fr

Professor Malgorzata (Gosia) Lekka opens the #AFMBioMed 2025 conference. Beautiful and complete perspective on mechanics of disease. Delighted to have such a fantastic keynote speaker #rolemodel

The #AFMBioMed 2025 conference is back in Barcelona after its first edition in 2007. Thank you Marina Giannotti for the organisation. And thank you Daniel Navajas, Jean-Luc Pellequer, Josep Samitier and Jordi Garcia for the opening

Join us for this small, intensive workshop in the remote Alpine town of Arolla, where we will explore the dynamics of living systems across scales, from the cytoskeleton to embryos. Let’s dive into how cellular and tissue-scale dynamics shape life itself! meetings.ls2.ch/arolla2025

Rendez-vous vendredi 7 mars ⤵️
Rassemblement à Marseille à 12h devant le Museum d'Histoire Naturelle au Palais Longchamp.
Toutes les infos ici : www.univ-amu.fr/fr/public/ac...