Cancer Screening & Prevention Research Group

Thrilled to share that Fangqing Li has been awarded a China Scholarship Council @imperialcollegeldn.bsky.social Scholarship!

She'll rejoin CSPRG in July as a fully funded PhD student, focusing on early-onset colorectal cancer.

Welcome back Fangqing!

#PhD #CancerResearch @imperialsandc.bsky.social

@imperialbrc.bsky.social-funded Dr Rhea Harewood & Kelly Gleason led a great #BowelCancerAwareness online session, supported by @imperialsandc.bsky.social, with Harrow THCOGIC Church members last week!

They covered bowel cancer causes, public involvement in research, & Rhea's future research plans

A huge thank you to the 3 brilliant speakers (& their supportive colleagues) from @imperialnhs.bsky.social, @imperialsandc.bsky.social who joined Dr Harewood for a PPI session with 58 EKTA Harrow community members

Valuable discussions had on breast & prostate cancer awareness & current research!

More @cancerresearchuk.org #PrevConf25 final day action
✅Heavyweight academics slug it out over GLP1 agonists importance (or not) for #cancerprevention
✅Prof Karen Brown weighs in on drugs for precision cancer prevention

www.cancerresearchuk.org/funding-for-...

Busy week catching up with all the latest in #cancerprevention at @cancerresearchuk.org #PrevConf25
✅Pressing agenda
✅Brilliant talks
✅Thought-provoking debates
✅Opportune catch-up with colleagues & collaborators

www.cancerresearchuk.org/funding-for-...

Come see our researchers present their research next week and check out our Keynote as well!!!

@imperialmed.bsky.social @imperial-csprg.bsky.social @imperial-edu.bsky.social @imperialcollegeldn.bsky.social

This is the first study to show an association between distal polyp characteristics & long-term proximal colon cancer risk, helping to inform who might benefit from colonoscopy, and providing evidence for future updates of post-polypectomy surveillance guidelines.

Read it here: t.co/P6P4wA8zxF

New analyses of #UKFSST data identify distal polyp characteristics associated with future proximal colon cancer risk.

Funders: @cancerresearchuk.org @nihr.bsky.social

Authors: R Harewood, K Wooldrage, E Robbins, J Kinross, C Wagner & AJ Cross

Journal: @bmj.com Open Gastroenterology

New paper alert!

Larger or high-grade dysplastic distal adenomas found on flexi-sig screening are associated with ⬆️ risk of future proximal colon cancer.

No associations for number or histology of distal adenomas or any distal hyperplastic polyp characteristics

@bmj.com OpenGastro
t.co/P6P4wA8zxF

We took a break from the office to celebrate the successful PhD vivas of both Emma and Sharon with a sunny picnic! It was great to have the opportunity to mark this achievement as a group, congratulations to you both!
#PhDone

Thanks @qubelfastofficial.bsky.social @helencolemanqub.bsky.social for inviting Amanda J Cross to give the Charlotte Jackson Gift Lecture today! A great opportunity to share our @cancerresearchuk.org funded work on #BowelCancer early detection & how our findings are influencing policy & patient care

4 years ago... #timeflies

A huge congratulations to our brilliant @imperialsandc.bsky.social
@cancerresearchuk.org #PhD - Dr Emma Robbins! - on successfully passing her #viva today!

An incredible achievement and well-deserved recognition of her hard work and dedication. We are so proud to celebrate with her!

😀👏🥳

Post doc Dr Rhea Harewood sharing #BowelCancerAwareness at a community outreach event with the Harrow THCOGIC church.

The group discussed how #BowelCancer is caused, how we can screen to find it earlier and how to improve public involvement in bowel cancer research

#EDI #CancerResearch

Improving involvement of EDI groups in #BowelCancer research is essential to make medical research more equitable

Rhea Harewood & Kelly Gleason collaborated with the Asian Women Cancer Group to hear their opinions on Rhea's future bowel #CancerResearch plans!

#BowelCancerAwareness

It's #BowelCancerAwareness Month

Spotlight on our @nihr.bsky.social post-doc Dr Rhea Harewood's work to improve involvement & participation of minority ethnic groups in #BowelCancer research

This work is funded by the @imperialsandc.bsky.social and @imperialcollegeldn.bsky.social EDI seed funds!

8/8
Impact

Effective allocation of surveillance colonoscopies is crucial to protect higher-risk pts from CRC while minimising invasive procedures for low-risk pts.

Our unique data will inform recommendations for ongoing surveillance in future post-polypectomy surveillance guidelines.

7/8
Conclusion

Pts with high-risk findings at both baseline & SC1 needed a second surveillance colonoscopy, whereas those with low-risk findings at SC1 did not, regardless of their baseline findings.

We couldn't draw conclusions for the LR-HR group due to limited CRC cases.

6/8
Findings:

Compared to the general population, CRC incidence after SC1 was:
▪️ ~0.5 times lower in the LR-LR group
▪️ - Non-significantly different in the HR-LR or LR-HR groups, although the 95%CI for the LR-HR group was wide due to few CRC cases
▪️ - ~3 times higher in the HR-HR group

5/8
Methods

We examined CRC incidence after SC1. Median follow-up was 8 years. CRC incidence in each group was then compared with that in the general population.

4/8
Methods

10,508 pts were split into 4 groups defined by their findings at baseline & at SC1
- ‘Low-risk, low-risk’ (LR-LR)
- ‘High-risk, low-risk’ (HR-LR)
- ‘Low-risk, high-risk’ (LR-HR)
- ‘High-risk, high-risk’ (HR-HR)

3/8
Background

Pts at ⬆️ risk of CRC after polyp removal are recommended to have post-polypectomy surveillance to protect against future CRC.

However, there are limited data to support recommendations for ongoing surveillance beyond SC1.

2/8
What
A retrospective, cohort analysis of pts who underwent baseline colonoscopy with polyp removal & had ≥1 check-up colonoscopies (‘post-polypectomy surveillance’).

Authors: E Robbins, K Wooldrage, M Rutter, A Veitch & A J Cross
Funding: @cancerresearchuk.org @nihr.bsky.social

1/8
Which patients under surveillance for colorectal cancer (CRC) after polyp removal need to continue having surveillance beyond the 1st surveillance colonoscopy (SC1)?

Our new analysis in Gut @BMJ.com examines which pt groups need ongoing surveillance.

gut.bmj.com/cgi/rapidpdf...

At the CSPRG, we're aiming to reduce the number of people being diagnosed & dying from #ColorectalCancer

Watch this space for future work on colorectal cancer risk and diet & lifestyle, how best to screen for CRC, and how to protect those at high risk from this cancer

#CSPRGWeekOfResearch

#CSPRGWeekOfResearch

Our data from @imperialcollegeldn.bsky.social PhD Emma Robbins is helping to develop the future of #ColorectalCancer screening guidelines

Women with low-risk distal polyps at flexi-sig screening were at 2x⬆️risk of proximal colon cancer compared to general population

Flexi-sig screening & colorectal cancer risk: Are we missing women at increased risk of proximal colon cancer?

Read our analysis of UKFSST data in @BMJ.com to discover if flexi-sig is sufficient to protect people with low-risk polyps

journals.sagepub.com/doi/10.1177/...

#CSPRGWeekOfResearch

Our @CancerResearchUK.org & @NIHR.bsky.social funded work showed that quantitative data from serial FITs could predict ACN risk:

- No change in serial FIT results was associated with a ⬇️ ACN detection rate
- Serial increases were associated with⬆️ ACN detection rates

#CSPRGWeekOfResearch

#CSPRGWeekOfResearch continues with FIT testing for colorectal cancer surveillance.

In our @BMJ.com paper from our @imperialSandC.bsky.social PhD student Gemma, we show that multiple FITs could help reduce the burden of surveillance on NHS endoscopy services

bmjopengastro.bmj.com/content/12/1...

A single flexible sigmoidoscopy can cut bowel cancer risk by an astounding 25%.

This protective effect lasts for 21 years.

Our evidence of flexi-sig efficacy is contributing to ongoing discussions on how to improve bowel cancer screening guidelines

#CSPRGWeekOfResearch