Sébastien Bontemps-Gallo, Ph.D.

Maladie de Lyme : comment la bactérie Borrelia burgdorferi nous infecte Transmise par les tiques, la maladie de Lyme est causée par des bactéries capables de se camoufler, de s’adapter et de résister à nos défenses immunitaires grâce à d’ingénieux stratagèmes.

🦠 "Maladie de Lyme : comment la bactérie Borrelia burgdorferi nous infecte", un article de @sebbontempsgallo.bsky.social (@cnrs-hautsdefrance.bsky.social / @univlille.bsky.social) pour @france.theconversation.com 👇
theconversation.com/maladie-de-l...

Selective accumulation of nanoparticles in infected cells for targeted drug delivery In response to the escalating threat of infectious diseases and antimicrobial resistance, novel therapeutic strategies are under active development. A…

📢 A new pub in Journal of Controlled Release by Dr @arnaudmachelart.bsky.social group and Dr Ruxandra Gref team

“Selective accumulation of nanoparticles in infected cells for targeted drug delivery”

@inserm.fr @cnrs-hautsdefrance.bsky.social @rechercheulille.bsky.social @pasteurlille.bsky.social

Maladie de Lyme : comment la bactérie « Borrelia burgdorferi » nous infecte Transmise par les tiques, la maladie de Lyme est causée par des bactéries capables de se camoufler, de s’adapter et de résister à nos défenses immunitaires grâce à d’ingénieux stratagèmes.

#Recherche
Issus du décryptage de la méthode de camouflage très efficace de la bactérie responsable de la maladie de #Lyme, 2 projets de #vaccins permettent de l’attaquer avant qu’elle ne puisse recourir à ce stratagème.
Par @sebbontempsgallo.bsky.social de @cnrs.fr

Félicitations pour cette nouvelle étape et bonne continuation à Bordeaux !

@pasteurlille.bsky.social @rechercheulille.bsky.social @cnrs.fr @cnrsbiologie.bsky.social @inserm.fr @chulille.bsky.social

Maladie de Lyme : comment la bactérie « Borrelia burgdorferi » nous infecte Transmise par les tiques, la maladie de Lyme est causée par des bactéries capables de se camoufler, de s’adapter et de résister à nos défenses immunitaires grâce à d’ingénieux stratagèmes.

Nouvel article dans @theconversation.com FR : Maladie de Lyme : comment la bactérie Borrelia burgdorferi nous infecte
Comment cette bactérie déjoue notre système immunitaire et inspire de nouvelles pistes vaccinales

@cnrs-hautsdefrance.bsky.social @univlille.bsky.social

🚨 Postdoc Opportunity – Pathogen-Host Interaction 🚨 (2.5y)

🦠 Join our team to uncover the molecular mechanisms of Y. pestis infection in fleas within a @anrs-mie.bsky.social PEPR-funded project!

🔬 Profile: PhD in microbiology

#Postdoc #Microbiology #YersiniaPestis #ResearchJobs

🚨 Postdoc Opportunity – Pathogen-Host Interaction 🚨

🦠 Join our team to uncover the molecular mechanisms of Y. pestis infection in fleas within a PEPR-funded project! (2.5y)

🔬 Profile: PhD in microbiology

#Postdoc #Microbiology #YersiniaPestis #ResearchJobs

@cnrs-hautsdefrance.bsky.social @univlille.bsky.social @rechercheulille.bsky.social @inserm.fr

The Plague & Yersinia pestis team @pasteurlille.bsky.social , led by F Sebbane, shared their latest research at the Yersinia 15th Symposium in Ulaanbaatar! A Baillez presented his thesis work, A Dewitte and @sebbontempsgallo.bsky.social showcased their recent findings.
@rolandelliagus.bsky.social

First day of the 15th International #Yersinia symposium in Ulaanbaatar, Mongolia

🎓 Funded PhD position available in the team of M. Pichavant & P. Gosset! Send your CV and a brief note on why you’re excited about this opportunity.

@cnrs-hautsdefrance.bsky.social @pasteurlille.bsky.social @univlille.bsky.social @inserm.fr @chulille.bsky.social

Cas de peste détecté aux États-Unis : peut-on encore mourir de cette maladie ? | Ouest-France [Ouest-France] Un cas de peste a été détecté en Californie, aux États-Unis, mardi 19 août. Pourrait-on voir réapparaître la bactérie responsable de la maladie en France, où la dernière infection connu...

⚠️ Cas de peste détecté aux USA : peut-on encore mourir de cette maladie ? Le 19 août 2025 un cas a été confirmé en Californie

Dans un article @ouest-france.fr Dr Sebbane, Chef d'équipe @inserm.fr fait le point.

@pasteurlille.bsky.social @cnrs-hautsdefrance.bsky.social @rechercheulille.bsky.social

Protocol to monitor activation of a two-component system in Dickeya dadantii during chicory leaf infection using Phos-tag gel Quantifying the phosphorylation levels of proteins involved in bacterial signaling pathways is essential for understanding their role in stress adaptation and infection processes. Here, we present a protocol for the semi-quantitative assessment of the phosphorylation level of the transcriptional regulator CpxR during the infection process using Phos-tag gel. We describe steps for Dickeya dadantii infection of chicory leaves, followed by bacterial extraction, rapid acidic cell lysis, and subseque...

Protocol to monitor activation of a two-component system in Dickeya dadantii during chicory leaf infection using Phos-tag gel #protocol #starprotocols #cellpress

Insights into Yersinia pestis evolution through rearrangement analysis of 242 complete genomes - Nature Genetics Analysis of synteny blocks and genomic rearrangement patterns of 178 newly sequenced and 64 publicly available complete genomes of Yersinia pestis highlights the impact of key variations on genes invo...

Just out in Nature Genetics @natureportfolio.nature.com !

Wu et al. analyzed 242 Yersinia pestis genomes, uncovering IS-driven rearrangements, which enhanced #phylogenetic resolution and resolved the third #pandemic’s polytomy, revealing adaptive changes in #virulence and #stress response.

This work was funded by the @cnrs.fr through MITI and the @agencerecherche.bsky.social

@pasteurlille.bsky.social @univlille.bsky.social @fst-ulille.bsky.social @inserm.fr @chulille.bsky.social

Protocol to monitor activation of a two-component system in Dickeya dadantii during chicory leaf infection using Phos-tag gel Quantifying the phosphorylation levels of proteins involved in bacterial signaling pathways is essential for understanding their role in stress adapta…

New pub in STAR Protocols @cp-starprotocols.bsky.social to detect the phosphorylation level of response regulators of two-component systems during host infection using a Phos-tag approach.

By @ugsf-lille.bsky.social @ciilofficiel.bsky.social
@univlille.bsky.social @cnrs-hautsdefrance.bsky.social

[Resources]

#AlphaFold protein and PPI prediction databases

1️⃣ Predictomes (genome maintenance & H2A/H2b) predictomes.org

2️⃣ Flypredictome www.flyrnai.org/tools/fly_pr...

3️⃣ Human interactome prodata.swmed.edu/humanPPI

4️⃣ BFVD (viral proteins) bfvd.steineggerlab.workers.dev

1/2

Bacterial cell wall & periplasm paradigm shift - important read #MicroSky

www.nature.com/articles/s41...

Climate differentially impacts ticks infected and uninfected with Borrelia burgdorferi Climate parameters show negative correlations with B. burgdorferi infection prevalence but low impact on uninfected tick density.

#Climate extremes may reduce #Lymedisease risk?

Broughton et al. show Borrelia burgdorferi prevalence in Ixodes pacificus ticks declines under climate stress—challenging long-held assumptions about vector-borne disease and global warming.

#VectorBiology

We will soon hire a postdoctoral fellow. Please contact me for more details.

#VSS
Merci @thiebaultceline.bsky.social de faire vivre la coalition féministe entre associations et parlementaires pour une loi cadre intégrale.

Les travaux avancent !
Pour les concrétiser il faudra évidemment aussi des moyens #PLF2026

@socialistesan.bsky.social @socialistes-senat.bsky.social

A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily - Nature Communications This study reveals that an outer membrane protein from the predator Bdellovibrio bacteriovorus forms a pentameric assembly that traps a lipid monolayer within. This allows the discovery of two superfa...

You thought all OMPs were trimeric? 🧐 Not in our predator B. bacteriovorus! 🦠
Excited to have contributed to this great collab with the Lovering lab on this intriguing protein. @lalouxlab.bsky.social
👉 Paper here!
www.nature.com/articles/s41...

#BacterialPredation #Bdellovibrio #StructuralBiology

A new study delivers the most comprehensive phylogenomic analysis of Spirochaetes to date, revealing their deep evolutionary roots and shedding light on the loss of spiral morphology and host adaptation.
✍️ @microbiomol.bsky.social and coll. @pasteur.fr
📖 shorturl.at/UxAWu
#MicroSky

Matters Microbial #31: Spirochetes do things...differently Today, Dr. Brian Stevenson of the University of Kentucky College of Medicine joins the #QualityQuorum to discuss a twisty twirling form of life, spirochetes,...

Recently interviewed by Mark Martin for his “Matters Microbial” podcast!

m.youtube.com/watch?si=O6w...

An insight into the draft genome of the Oriental rat flea, Xenopsylla cheopis, together with its Wolbachia endosymbiont - BMC Genomics Background The Oriental rat flea, Xenopsylla cheopis, is a main vector of plague caused by the bacterium Yersinia pestis. Transcriptomic analysis of this insect and the interaction between Yersinia an...

At long last, the genome of Xenopsylla cheopis — the infamous Oriental rat flea and historic vector of plague — has been sequenced and published!

A genomic treasure trove for vector biologists, evolutionary entomologists, and plague researchers alike.

#Genomics #Entomology #VectorBiology #NIH

Beta-cyclodextrins in infectious disease therapy: A review of their function beyond simple drug carriers Cyclodextrins (CDs) are cyclic oligosaccharides derived from starch through enzymatic conversion. Over the past decades, CDs and their derivatives (dC…

🚨 New review from our group!
PhD student Amine Pochet dives into the use of cyclodextrins beyond drug delivery — as active agents against infectious diseases.
@ciilofficiel.bsky.social @pasteurlille.bsky.social @inserm.fr @univlille.bsky.social

www.sciencedirect.com/science/arti...

In-host evolution of Yersinia enterocolitica during a chronic human infection - Nature Communications This study documents the evolution of antibiotic resistance and major growth defects in Yersinia enterocolitica in a patient over 14 years, revealing genetic changes that shed light on bacterial adapt...

1/8 - New in @natcomms.nature.com !
☣️ Meet Yersinia enterocolitica (Ye) — a lesser-known but still dangerous cousin of Yersinia pestis.
We uncover how this invasive pathogen can survive and adapt for 14 years inside a human host under constant antibiotic pressure 👇
www.nature.com/articles/s41...

Special thanks to Dr @brandonrobin.bsky.social !

The project was carried out at @ciilofficiel.bsky.social ( @cnrs-hautsdefrance.bsky.social @inserm.fr @pasteurlille.bsky.social @univlille.bsky.social ) with financial support from @agencerecherche.bsky.social and @erc.europa.eu

Exploring temperature-dependent transcriptomic adaptations in Yersinia pestis using direct cDNA sequencing by Oxford Nanopore Technologies - Scientific Reports Scientific Reports - Exploring temperature-dependent transcriptomic adaptations in Yersinia pestis using direct cDNA sequencing by Oxford Nanopore Technologies

📢 Our latest article is out!
We present a cost-effective in-house #RNASeq workflow using @nanoporetech.com direct cDNA, perfect for high-risk pathogens.
Applied to #Yersinia pestis, transcriptomic profiling (21 °C/flea vs 37 °C/host) reveals novel operons & sulfur metabolism upregulation.