@tesscacciottolo.bsky.social
Clinician Scientist interested in causes of steatotic liver disease and obesity. Hepatologist. Chain Florey TTI Fellow @mrc-lms.bsky.social
In science is awesome news: Amazing they were able to identify the cause in this family as glucagon missense mutation, show the damage it does and tie it back to a now dead drug class(glucagon antagonists) and why glucagon agonists are the better bet especially for liver disease.
03.09.2025 11:49 — 👍 4 🔁 2 💬 0 📌 0#4
With thanks to our collaborators and funders @cambridgebrc.bsky.social @wellcometrust.bsky.social @tesscacciottolo.bsky.social
📢 We’re hiring a Research Assistant!
Join the LMS to support cutting-edge research in fatty liver disease alongside a Clinician Scientist. Apply now:
lms.mrc.ac.uk/work/vacanci...
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Low cysteine, low GSH, upregulation of the hepatic ISR and OSR with weight loss are reminescent of early liver failure. Intriguing that the proposed application of the science is in obesity management, and begs the question of whether the translational statement has enhanced the paper in this case.
24.05.2025 17:02 — 👍 1 🔁 0 💬 0 📌 0
members of chain Florey pose for a picture
woman in a blue top
man in pink shirt listens to a talk
a man in a suit asks a question
At the LMS, we value the important role clinician scientists play in advancing medical research.
Our recent away day for our Chain Florey clinician scientist fellows was a huge success! The day was filled with insightful talks from our fellows, meaningful discussions and valuable career advice.
Congrats Matt and colleagues! Great story.
05.04.2025 16:27 — 👍 0 🔁 0 💬 0 📌 0VTA dopamine-releasing neurons encode palatability and control the consummatory phase of eating dependent on the specific timing of their activity, actions suppressed by activation of GLP-1R signaling during palatable food consumption #weightloss #obesity www.science.org/doi/10.1126/...
27.03.2025 18:27 — 👍 5 🔁 4 💬 0 📌 0Come and study with us for a Masters!
25.03.2025 19:28 — 👍 0 🔁 3 💬 0 📌 0
Ascites is like carrying around a hot tub:
Huge energy bill!
1⃣Kilocalorie= energy to 🔥1L by 1°C
2⃣Ascites=Heating ~5-10L to 36°C 24hrs/day
3⃣Energy comes from body breakdown (sarcopenia)
If you⬇️ascites➡️the energy bill falls
Help patients. ⬇️the ascites!!! #liversky
Amazing #ChainFlorey Retreat Day! happy to be part of this exciting community of young #clinicianscientists
14.03.2025 19:00 — 👍 8 🔁 4 💬 0 📌 0
openRxiv has arrived!
We’re thrilled to announce the launch of openRxiv as an independent, researcher-led nonprofit to oversee bioRxiv and medRxiv, the world’s leading preprint servers for life and health sciences.
openrxiv.org/introducing-...
#openRxiv #OpenScience #Preprints #bioRxiv #medRxiv
Very exciting announcement and bodes well for A1ATD and other genetic disorders affecting the liver. #RareDisease
11.03.2025 10:08 — 👍 0 🔁 0 💬 0 📌 0
28.02.2025 12:49 — 👍 0 🔁 0 💬 0 📌 0
Excited to be at #DiabetesUK in Glasgow to talk about Mechanisms of #MASLD.
28.02.2025 12:49 — 👍 0 🔁 0 💬 1 📌 0many have been convinced to buy supplements recommended by influencers who promise better health
rarely they cause life threatening side effects.
Like liver failure
But influencers aren’t there to help when 💩 goes down.
New Phase 3a study showing efficacy of liraglutide for treating childhood obesity.
This is a very exciting area and I look forward to the extension study & real world data.
What are the long term health & health economic outcomes of early intervention in this chronic, relapsing condition?
Clinical researchers: reversing the decline. This report evidences the attrition of UK #clinicianscientists especially in more senior roles. Recognition that this is a group with distinct needs. Flexibility and re-expansion of opportunities required. Commitment from both NHS & universities.
01.02.2025 06:47 — 👍 2 🔁 0 💬 0 📌 0
We tend to think that all decompensated cirrhosis are the same. During the 12 years that I practiced in the USA, I learnt that MASLD cirrhosis is different.
See below the 10 more common specific medical issues of MASLD CIRRHOSIS that I found:
Genes & Health is excited to contribute 55,000 high-quality exomes from British South Asian volunteers to gnomAD, a global genetic resource. This open-access data will advance rare disease diagnosis and treatment, thanks to our amazing volunteers. #GenesAndHealth #Genomics #RareDiseases
27.01.2025 16:34 — 👍 7 🔁 3 💬 0 📌 0Important piece of work on the definition of #obesity, and its designation as a #disease.
Provides a framework for addressing the problem at the level of an individual patient.
Crucial implications for access to therapy for those who really need it.
www.thelancet.com/commissions/...
New year, new role, new social media platform. Looking forward to forging new collaborations, strengthening old ones and more great science in 2025. 🥳
05.01.2025 11:46 — 👍 4 🔁 0 💬 0 📌 0
