Tessa Cacciottolo

Research Assistant MED05360 - MRC Laboratory of Medical Sciences We are looking for a motivated and enthusiastic individual to join Dr Tessa Cacciottolo’s research team at the MRC Laboratory of Medical Sciences (LMS). Dr Cacciottolo is a clinician scientist working...

📢 We’re hiring a Research Assistant!
Join the LMS to support cutting-edge research in fatty liver disease alongside a Clinician Scientist. Apply now:
lms.mrc.ac.uk/work/vacanci...

17.07.2025 15:13 — 👍 3    🔁 2    💬 0    📌 0

Science Technology Graduate Programme - MRC Laboratory of Medical Sciences Bioinformatics Facility - Dr George Young and Electron Microscopy Facility - Dr Ricardo Aramayo

Are you a recent UK graduate without an MSc, eager to launch your career in biomedical research?

Apply now for our two-year Science Technology Graduate Programme!

You'll gain hands-on experience in state-of-the-art research facilities, build technical expertise and earn a competitive salary.

04.07.2025 13:58 — 👍 5    🔁 5    💬 0    📌 0

Low cysteine, low GSH, upregulation of the hepatic ISR and OSR with weight loss are reminescent of early liver failure. Intriguing that the proposed application of the science is in obesity management, and begs the question of whether the translational statement has enhanced the paper in this case.

24.05.2025 17:02 — 👍 1    🔁 0    💬 0    📌 0

members of chain Florey pose for a picture

woman in a blue top

man in pink shirt listens to a talk

a man in a suit asks a question

At the LMS, we value the important role clinician scientists play in advancing medical research.

Our recent away day for our Chain Florey clinician scientist fellows was a huge success! The day was filled with insightful talks from our fellows, meaningful discussions and valuable career advice.

24.03.2025 10:58 — 👍 2    🔁 1    💬 0    📌 0

Congrats Matt and colleagues! Great story.

05.04.2025 16:27 — 👍 0    🔁 0    💬 0    📌 0

Hedonic eating is controlled by dopamine neurons that oppose GLP-1R satiety Hedonic eating is defined as food consumption driven by palatability without physiological need. However, neural control of palatable food intake is poorly understood. We discovered that hedonic eatin...

VTA dopamine-releasing neurons encode palatability and control the consummatory phase of eating dependent on the specific timing of their activity, actions suppressed by activation of GLP-1R signaling during palatable food consumption #weightloss #obesity www.science.org/doi/10.1126/...

27.03.2025 18:27 — 👍 5    🔁 4    💬 0    📌 0

Come and study with us for a Masters!

25.03.2025 19:28 — 👍 0    🔁 3    💬 0    📌 0

Ascites is like carrying around a hot tub:

Huge energy bill!

1⃣Kilocalorie= energy to 🔥1L by 1°C
2⃣Ascites=Heating ~5-10L to 36°C 24hrs/day
3⃣Energy comes from body breakdown (sarcopenia)

If you⬇️ascites➡️the energy bill falls

Help patients. ⬇️the ascites!!! #liversky

22.03.2025 00:30 — 👍 26    🔁 4    💬 0    📌 0

Amazing #ChainFlorey Retreat Day! happy to be part of this exciting community of young #clinicianscientists

14.03.2025 19:00 — 👍 7    🔁 4    💬 0    📌 0

openRxiv has arrived!

We’re thrilled to announce the launch of openRxiv as an independent, researcher-led nonprofit to oversee bioRxiv and medRxiv, the world’s leading preprint servers for life and health sciences.
openrxiv.org/introducing-...

#openRxiv #OpenScience #Preprints #bioRxiv #medRxiv

11.03.2025 13:18 — 👍 400    🔁 231    💬 3    📌 19

Very exciting announcement and bodes well for A1ATD and other genetic disorders affecting the liver. #RareDisease

11.03.2025 10:08 — 👍 0    🔁 0    💬 0    📌 0

28.02.2025 12:49 — 👍 0    🔁 0    💬 0    📌 0

Excited to be at #DiabetesUK in Glasgow to talk about Mechanisms of #MASLD.

28.02.2025 12:49 — 👍 0    🔁 0    💬 1    📌 0

many have been convinced to buy supplements recommended by influencers who promise better health

rarely they cause life threatening side effects.

Like liver failure

But influencers aren’t there to help when 💩 goes down.

09.02.2025 17:36 — 👍 14    🔁 3    💬 1    📌 0

New Phase 3a study showing efficacy of liraglutide for treating childhood obesity.

This is a very exciting area and I look forward to the extension study & real world data.
What are the long term health & health economic outcomes of early intervention in this chronic, relapsing condition?

09.02.2025 10:17 — 👍 0    🔁 0    💬 0    📌 0

Clinical researchers: reversing the decline. This report evidences the attrition of UK #clinicianscientists especially in more senior roles. Recognition that this is a group with distinct needs. Flexibility and re-expansion of opportunities required. Commitment from both NHS & universities.

01.02.2025 06:47 — 👍 1    🔁 0    💬 0    📌 0

We tend to think that all decompensated cirrhosis are the same. During the 12 years that I practiced in the USA, I learnt that MASLD cirrhosis is different.

See below the 10 more common specific medical issues of MASLD CIRRHOSIS that I found:

29.01.2025 04:48 — 👍 7    🔁 5    💬 1    📌 0

Genes & Health is excited to contribute 55,000 high-quality exomes from British South Asian volunteers to gnomAD, a global genetic resource. This open-access data will advance rare disease diagnosis and treatment, thanks to our amazing volunteers. #GenesAndHealth #Genomics #RareDiseases

27.01.2025 16:34 — 👍 7    🔁 3    💬 0    📌 0

Definition and diagnostic criteria of clinical obesity

Important piece of work on the definition of #obesity, and its designation as a #disease.

Provides a framework for addressing the problem at the level of an individual patient.

Crucial implications for access to therapy for those who really need it.

www.thelancet.com/commissions/...

23.01.2025 20:55 — 👍 1    🔁 0    💬 0    📌 0

New year, new role, new social media platform. Looking forward to forging new collaborations, strengthening old ones and more great science in 2025. 🥳

05.01.2025 11:46 — 👍 3    🔁 0    💬 0    📌 0