Danny Gold

A pivot-tether model for nucleosome recognition by the chromosomal passenger complex | EMBO reports imageimageAurora B is targeted to chromatin subdomains by the chromosome passenger complex, formed by survivin, borealin and INCENP. Spatial restriction of Aurora B adjacent to kinetochores is importa...

Work from the Barr lab @oxfordbiochemistry.bsky.social keeps on coming. Fantastic mechanistic work!

Time as a danger signal promoting G1 arrest after mitosis Cell cycle checkpoints preventing the replication and inheritance of damaged DNA are crucial for maintaining genome stability and stopping the growth of damaged cells. Canonical checkpoints do this by preventing passage between cell cycle phases until damage has been repaired, or by promoting cell cycle exit. Herein we review checkpoint integration between cell cycle phases, specifically findings showing that extended spindle assembly checkpoint surveillance in mitosis is a danger signal triggering G1 cell cycle arrest. Evidence linking mitotic delays induced by activation of the spindle assembly checkpoint with positive and negative regulators of the G1 DNA damage checkpoint target p53 is discussed, with a focus on time-dependent changes to a p53-binding deubiquitinating complex USP28–53BP1 and the p53 ubiquitin-ligase mouse double minute homologue 2 (MDM2), respectively.

Time as a danger signal promoting G1 arrest after mitosis

Time as a danger signal promoting G1 arrest after mitosis Cell cycle checkpoints preventing the replication and inheritance of damaged DNA are crucial for maintaining genome stability and stopping the growth of damaged cells. Canonical checkpoints do this by...

Our latest review paper on “Mitotic Timer” is now published in Trends in Cell Biology @cp-trendscellbio.bsky.social

Check this out here 👉 Time as a danger signal promoting G1 arrest after mitosis www.cell.com/trends/cell-...

#cellcycle @oxfordbiochemistry.bsky.social

WIP1 mutations suppress DNA damage triggered bypass of the mitotic timer | The EMBO Journal imageimageProlonged delays in mitosis and G2 DNA-damage stress both lead to cell-cycle arrest in G1. This work shows how these pathways normally lead to G1 arrest by different routes, and how cancer-a...

Happy to share our latest work from the Barr lab is now published in @embojournal.org

👉 WIP1 mutations suppress DNA damage triggered bypass of the mitotic timer | EMBO Journal

#cellcycle
@oxfordbiochemistry.bsky.social

www.embopress.org/doi/full/10....

🔬I contributed super-resolution TauSTED microscopy data on the CPC, Aurora B kinase & kinetochores, using the Leica Stellaris at Micron Oxford's Bioimaging facility

I'm grateful to be part of this collaborative effort! Read the paper in @emboreports.org here:

www.embopress.org/doi/full/10....

🎉 Excited to share my first paper as 2nd author! From the Barr & Gruneberg labs, this work explores the structure of the Chromosome Passenger Complex (CPC) and suggests a ‘pivot–tether’ model for how it binds H3pT3-phosphorylated nucleosomes
@oxfordbiochemistry.bsky.social @dunnschool.bsky.social

Well done to DPhil Reubenite Danny Gold who has been announced as a winner in @cancerresearchuk.org's #ResearchIsBeautiful campaign.

His winning image (shown below) captures microtubules attaching to chromosomes via kinetochores to form mitotic spindles.

Thank you @cancerresearchuk.org for showcasing some of my super-resolution microscopy! 🔬

Cancer beats the clock New research unveils the important role of cell division timing mechanisms in the formation of cancer

The Barr lab @ox.ac.uk has discovered the important role of cell division timing mechanisms in the formation of cancer. The research, funded by Cancer Research UK, provides valuable insight into how damaged cells are normally stopped from growing. ⬇️ bit.ly/202502-barr