Pavel Kielkowski

Great talk by Ronald Micura about Challenges in biological RNA chemistry @lmumuenchen.bsky.social 😀

Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense infection. However, modified nucleosides common in self-RNA—most notably pseudouridine—evade recognition. This study finds t...

I am very excited to share the second paper of my PhD published in @cp-cell.bsky.social.
Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor @v-hornung.bsky.social for their great support and collaboration!

www.cell.com/cell/fulltex...

Research Position (PhD) in organic chemistry and b... <div style="text-align: justify;">The&nbsp; research&nbsp; group&nbsp; „Organic&nbsp; Chemistry&nbsp; and&nb...

Join us! We are looking for a new team member (PhD student) with strong background in organic chemistry.
🙏 RETWEET (We want to recruit internationally)

Organic chemistry meets #DirectedEvolution
Highly interdisciplinary & passionate research group

uni-bielefeld.hr4you.org/job/view/433...

🎉 Nadace Experientia zná stipendisty pro rok 2025!

👨‍🔬 Jakub Copko z @iocbprague.bsky.social díky stipendiu ve výši 1 060 000 Kč vycestuje na University of Göttingen.

👨‍🔬 Lukáš Janecký z @iocbprague.bsky.social získal stipendium ve výši 1 215 000 Kč a zamíří na Stockholm University.

Gratulujeme!

🚀 PhD position at the intersection of medicinal chemistry and chemical biology.
You'll develop ferroptosis inhibitors to combat bacterial lung infections

🧪 Research (50%) /🎓 Teaching (50%)

Looking for someone with:
➡️ Strong background in organic synthesis
➡️ Passion for working across disciplines

Unifying the analysis of bottom-up proteomics data with CHIMERYS - Nature Methods CHIMERYS is a spectrum-centric and data acquisition method-agnostic algorithm for the analysis of MS2 spectra. It is capable of deconvoluting any MS2 spectrum, regardless of whether it was acquired by...

One algorithm to rule them all? CHIMERYS bridges the gap — DDA,DIA and PRM — together at last!
With #CHIMERYS, we can now directly compare DDA and DIA data — 🍎 to 🍎 finally made possible.
doi.org/10.1038/s41592-025-02663-w
#KusterLab #WilhelmLab #MSAID #Proteomics

Come join our team! We have an opening for a research associate ("Ratsstelle"). Expertise in nucleotide chemistry and LC-MS is required. 👉 job-portal.lmu.de/jobposting/b... Deadline for application is June 01, 2025.

Back in July 2023 we organized a small bioML symposium at @iocbprague.bsky.social, and it turned out to be a very pleasant and successful event. This summer we are following up with a great line-up of speakers. Please register for free, deadline May 30. tinyurl.com/bioMLPrague25

Self-assembled PROTACs enable glycoproteins degradation in the living cells We report here a two-component proteolysis targeting chimeras (PROTACs) strategy selectively targeting O-GalNAcylated and O-GlcNAcylated proteins for proteasomal degradation, which leads to severe tox...

Great to see the new concept of protein PTMs functionalization published in @chemicalscience.rsc.org! The GlyTACs enable selective degradation of glycoproteins in living cells. Congratulation to Haoyu and Liu. Have a look on the full story here: pubs.rsc.org/en/Content/A... #chembio

We are happy to announce the new team that will organize the Virtual ChemBioTalks from this edition onwards
Marina Rubini
@mlakemeyer.bsky.social
@michellefrei17.bsky.social
Hana Macíčková Cahová
@drglycoben.bsky.social
@borisvauzeilles.bsky.social
@stephanhacker2.bsky.social
(1/4)
#ChemBio #ChemSky

The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #ChemSky #ChemBio

The first chemistry.unwrapped video in the ENERGY series is out 💥🔥

Watch on YouTube in full quality:
www.youtube.com/watch?v=OdPT...

@chemistryunwrapped.bsky.social @juriceklab.bsky.social #ChemSky #PiSky

#research #chirality

Stereoanalysis of the Antiparasitic Natural Product Callunene and Its Synthetic Intermediates (Ferenczei, Perlíková) - JNP @acs.org: pubs.acs.org/doi/10.1021/...

@iocbprague.bsky.social #UCTPrague @czechacademy.bsky.social

Our newest paper on enzymatic synthesis of hypermodified zwitterionic DNA bearing 4 different cationic groups has just been published in NAR. doi.org/10.1093/nar/...

We are looking for PhD candidates to work in Paris at @sorbonne-universite.fr on synthesis & (photo)catalysis inside cyclodextrins with bimetallic complexes in collaboration with @metallacycle.bsky.social

Captain Haddock looking very frazzled, saying, “What a week, huh?” Tintin leans into the frame and says, “Captain, it’s Wednesday.” Snowy is very excited about the drink he has found.

🥳Congratulations, Matthias Tschöp! 🥂
Following our successful past collaborations in promoting young PIs to tenure-track professorships, we look forward to working with you to shape LMU’s future🤩

Bei ihr trifft Fachwissen auf didaktische Kompetenz: Die Studierenden von Prof. Dr. Lena Daumann @daumannl.bsky.social aus der Chemie @hhu.de sind begeistert und haben sie für den #hhuLehrpreis2025 nominiert. 🧪

‼️PhD Position in Chemical Biology at the University Antwerp‼️#chembio

✔️Deadline: ‼️February 20, 2025‼️
✔️Find full details and submit your application here: www.uantwerpen.be/en/jobs/vaca...

Superb! Welcome.

Thank you Stephan! Great to be here and discuss the #chembio

#chembio

AMPylation regulates PLD3 processing The 5’-3’ exonuclease phospholipase D3 (PLD3) is a single-pass transmembrane protein undergoing sequential post-translational modifications (PTM) by N -glycosylation, AMPylation and proteolytic cleava...

Proteoforms matter! We show how AMPylation impacts PLD3 proteolytic processing and catalytic activity. Congratulations to Laura Hoffmann and thanks to all collaborators @jaelab.bsky.social, @v-hornung.bsky.social, @hellmichgroup.bsky.social and Wei Xiang lab! www.biorxiv.org/content/10.1...

Self-Assembled PROTACs Enable Glycoproteins Degradation in the Living Cells. We report here a two-component proteolysis targeting chimeras (PROTACs) strategy selectively targeting O-GalNAcylated and O-GlcNAcylated proteins for proteasomal degradation, which leads to severe tox...

Post-translational modifications on proteins can serve as metabolic anchors to target selected proteins for degradation. We are excited to share our study on GlyTACs, a PROTAC modality targeting glycoproteins for proteosomal degradation. Check it out #chembio! chemrxiv.org/engage/chemr...

i cobbled together a science starter pack:
Neuronal Post-transcriptional / Protein Synthesis

agonizingly incomplete - join our growing community!
go.bsky.app/Qqq9HTw

Reflecting on 20 years of progress Nature Chemical Biology - The field of chemical biology has changed dramatically over the past 20 years. Here, we speak to Sarah E. O’Connor, Benjamin F. Cravatt and Chengqi Yi about the...

Reflecting on 20 years of progress

Sarah E. O’Connor, Benjamin F. Cravatt and Chengqi Yi talk about the major changes in chemical biology, the advances that have most affected their research, and their thoughts about the important questions facing chemical biologists.
rdcu.be/d5Sm0

Hay @carolynbertozzi.bskyverified.social ! I am bit slow to make the jump to @bsky.app. Now I need to figure out how to get a good feed going! Maybe if you follow me people will see my posts! Glad to be here!

Congratulation Michaela!!

Job alert: fully funded postdoc position in chemical biology in beautiful Geneva! Do you have a PhD in Chemical Biology or related field with organic synthetic experience? Apply now! Details on how to apply can be found here: www.hoogendoornlab.org/joinus #chemsky #ChemBio

Thanks to @sabschn.bsky.social, Didier and Schütz lab for great collaboration!