Pavel Kielkowski

What can HaloTag do for you?

Triggered fluorogenic labelling?
Molecular recording?
Photo-Chemically Induced Dimerisation?

Philipp Mauker's CHalo motif lets reagents do all three, and more.

Read the preprint here -
doi.org/10.1101/2025...

#chembio #fluorescence #cellbio #SLP

Great work! Congratulations.

Thank you Felix!

The final version of our article about PLD3 AMPylation is now out shorturl.at/iTxWx. One protein, many proteoforms. Congratulations to Laura and thanks to @marleenberouti.bsky.social @v-hornung.bsky.social @jaelab.bsky.social @hellmichgroup.bsky.social

New paper in great collaboration with @cardosolab.bsky.social on Super-Resolution Compatible DNA Labeling Technique Reveals Chromatin Mobility and Organization Changes During Differentiation published in Advanced Science: doi.org/10.1002/advs... @iocbprague.bsky.social

LMU remains the best German university In the latest Academic Ranking of World Universities, LMU ranks among the world’s top 50 research-intensive universities.

LMU remains the best German university www.lmu.de/en/newsroom/...

Open positions GR-SCHUHMACHER

We are hiring!

If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!

More information on www.epfl.ch/labs/gr-schu...

Great talk by Ronald Micura about Challenges in biological RNA chemistry @lmumuenchen.bsky.social 😀

Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense infection. However, modified nucleosides common in self-RNA—most notably pseudouridine—evade recognition. This study finds t...

I am very excited to share the second paper of my PhD published in @cp-cell.bsky.social.
Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor @v-hornung.bsky.social for their great support and collaboration!

www.cell.com/cell/fulltex...

Research Position (PhD) in organic chemistry and b... <div style="text-align: justify;">The&nbsp; research&nbsp; group&nbsp; „Organic&nbsp; Chemistry&nbsp; and&nb...

Join us! We are looking for a new team member (PhD student) with strong background in organic chemistry.
🙏 RETWEET (We want to recruit internationally)

Organic chemistry meets #DirectedEvolution
Highly interdisciplinary & passionate research group

uni-bielefeld.hr4you.org/job/view/433...

🎉 Nadace Experientia zná stipendisty pro rok 2025!

👨‍🔬 Jakub Copko z @iocbprague.bsky.social díky stipendiu ve výši 1 060 000 Kč vycestuje na University of Göttingen.

👨‍🔬 Lukáš Janecký z @iocbprague.bsky.social získal stipendium ve výši 1 215 000 Kč a zamíří na Stockholm University.

Gratulujeme!

🚀 PhD position at the intersection of medicinal chemistry and chemical biology.
You'll develop ferroptosis inhibitors to combat bacterial lung infections

🧪 Research (50%) /🎓 Teaching (50%)

Looking for someone with:
➡️ Strong background in organic synthesis
➡️ Passion for working across disciplines

Unifying the analysis of bottom-up proteomics data with CHIMERYS - Nature Methods CHIMERYS is a spectrum-centric and data acquisition method-agnostic algorithm for the analysis of MS2 spectra. It is capable of deconvoluting any MS2 spectrum, regardless of whether it was acquired by...

One algorithm to rule them all? CHIMERYS bridges the gap — DDA,DIA and PRM — together at last!
With #CHIMERYS, we can now directly compare DDA and DIA data — 🍎 to 🍎 finally made possible.
doi.org/10.1038/s41592-025-02663-w
#KusterLab #WilhelmLab #MSAID #Proteomics

Come join our team! We have an opening for a research associate ("Ratsstelle"). Expertise in nucleotide chemistry and LC-MS is required. 👉 job-portal.lmu.de/jobposting/b... Deadline for application is June 01, 2025.

Back in July 2023 we organized a small bioML symposium at @iocbprague.bsky.social, and it turned out to be a very pleasant and successful event. This summer we are following up with a great line-up of speakers. Please register for free, deadline May 30. tinyurl.com/bioMLPrague25

Self-assembled PROTACs enable glycoproteins degradation in the living cells We report here a two-component proteolysis targeting chimeras (PROTACs) strategy selectively targeting O-GalNAcylated and O-GlcNAcylated proteins for proteasomal degradation, which leads to severe tox...

Great to see the new concept of protein PTMs functionalization published in @chemicalscience.rsc.org! The GlyTACs enable selective degradation of glycoproteins in living cells. Congratulation to Haoyu and Liu. Have a look on the full story here: pubs.rsc.org/en/Content/A... #chembio

We are happy to announce the new team that will organize the Virtual ChemBioTalks from this edition onwards
Marina Rubini
@mlakemeyer.bsky.social
@michellefrei17.bsky.social
Hana Macíčková Cahová
@drglycoben.bsky.social
@borisvauzeilles.bsky.social
@stephanhacker2.bsky.social
(1/4)
#ChemBio #ChemSky

The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #ChemSky #ChemBio

The first chemistry.unwrapped video in the ENERGY series is out 💥🔥

Watch on YouTube in full quality:
www.youtube.com/watch?v=OdPT...

@chemistryunwrapped.bsky.social @juriceklab.bsky.social #ChemSky #PiSky

#research #chirality

Stereoanalysis of the Antiparasitic Natural Product Callunene and Its Synthetic Intermediates (Ferenczei, Perlíková) - JNP @acs.org: pubs.acs.org/doi/10.1021/...

@iocbprague.bsky.social #UCTPrague @czechacademy.bsky.social

Our newest paper on enzymatic synthesis of hypermodified zwitterionic DNA bearing 4 different cationic groups has just been published in NAR. doi.org/10.1093/nar/...

We are looking for PhD candidates to work in Paris at @sorbonne-universite.fr on synthesis & (photo)catalysis inside cyclodextrins with bimetallic complexes in collaboration with @metallacycle.bsky.social

Captain Haddock looking very frazzled, saying, “What a week, huh?” Tintin leans into the frame and says, “Captain, it’s Wednesday.” Snowy is very excited about the drink he has found.

🥳Congratulations, Matthias Tschöp! 🥂
Following our successful past collaborations in promoting young PIs to tenure-track professorships, we look forward to working with you to shape LMU’s future🤩

Bei ihr trifft Fachwissen auf didaktische Kompetenz: Die Studierenden von Prof. Dr. Lena Daumann @daumannl.bsky.social aus der Chemie @hhu.de sind begeistert und haben sie für den #hhuLehrpreis2025 nominiert. 🧪

‼️PhD Position in Chemical Biology at the University Antwerp‼️#chembio

✔️Deadline: ‼️February 20, 2025‼️
✔️Find full details and submit your application here: www.uantwerpen.be/en/jobs/vaca...

Superb! Welcome.

Thank you Stephan! Great to be here and discuss the #chembio

#chembio

AMPylation regulates PLD3 processing The 5’-3’ exonuclease phospholipase D3 (PLD3) is a single-pass transmembrane protein undergoing sequential post-translational modifications (PTM) by N -glycosylation, AMPylation and proteolytic cleava...

Proteoforms matter! We show how AMPylation impacts PLD3 proteolytic processing and catalytic activity. Congratulations to Laura Hoffmann and thanks to all collaborators @jaelab.bsky.social, @v-hornung.bsky.social, @hellmichgroup.bsky.social and Wei Xiang lab! www.biorxiv.org/content/10.1...