Sabine Ehrt

Very cool and impactful! Congratulations!

The Mycobacterium tuberculosis Transposon Sequencing Database (MtbTnDB): A Large‐Scale Guide to Genetic Conditional Essentiality Mtb transposon sequencing database is a unified resource for exploring conditional gene essentiality in Mycobacterium tuberculosis. By standardizing over 150 transposon sequencing screens, it enables...

Jinich et al. present an important new resource for the Mtb community!
The Mycobacterium tuberculosis Transposon Sequencing Database (MtbTnDB) is an interactive web resource summarizing 150+ published screens.
#MicroSky #Mycobacterium #tuberculosis
onlinelibrary.wiley.com/doi/10.1111/...

All credit goes to Gautier and you John! Beautiful work!

A) Diagram showing how EtfD transfers electrons from beta oxidation to the menaquinol pool in the membrane, linking beta oxidation to oxidative phosphorylation in mycobacteria. B) A growth curve showing the Mycobacterium smegmatis lacking EtfD can grow when glucose is provided as the carbon source, but has a slight growth delay. Complementing the ∆etfD strain with M. tuberculosis on a plasmid rescues the defect. C) A growth curve showing that ∆etfD M. smegmatis cannot grow on medium where the fatty acid oleic acid is the only carbon source. A plasmid with with M. tuberculosis EtfD rescues the defect.

EtfD links beta oxidation to OxPhos in mycobacteria - recent work suggests that targeting EtfD could shorten #tubeculosis treatment.
But how does EtfD work? And how can you assay its activity?
In his final PhD manuscript @courbongautier.bsky.social provides answers!
www.biorxiv.org/content/10.1...

Baby Is Healed With World’s First Personalized Gene-Editing Treatment

Simply incredible story of the triumph of the US biomedical research ecosystem. Think of all the strands of discovery over many decades that came together to save this child. In large part becuase of NIH. www.nytimes.com/2025/05/15/h...

Awesome news! Huge congratulations!

Tuberculosis myth: "Tuberculosis is easy to treat." Fact: Yes, with access to quality health care, tuberculosis (TB) is curable! And no: TB is expensive to cure (~$23K in the USA). TB Requires 4-6 months of daily treatment to cure. TB must be accurately diagnosed before it can be treated, and the tests are often unaffordable where they are most needed.

#Tuberculosis is the world's deadliest infectious disease, but it has a cure! However, because of cost, treatment length, and availability of testing, not everyone can complete treatment. www.who.int/news-roo...

Thank you Joanne!

Thanks Mike! It’ll be a journey…

Thank you!!

Awesome work! It will benefit many projects.

Pleased to highlight a new preprint from the lab. This is the work of my longtime collaborator in the lab Allison Fay, who wanated to create new tools for disocvery biology in mycobacteria, specifically a new sysem for protein localizaton and proximity proteomics.

www.biorxiv.org/content/10.1...

Gender equality doesn’t just 'happen.'

Women’s rights must be fought for and protected.

Our responsibility is clear.

To lead by example and create a world where opportunities are fair for all.

Not just today, but every single day.

#InternationalWomensDay

Incredibly proud of our NYC scientific community for standing up for SCIENCE! @standupforscience.bsky.social

😡😡😡😡

Your dignity honors the bravery of the Ukrainian people.

Be strong, be brave, be fearless.
You are never alone, dear President Zelenskyy.

We will continue working with you for a just and lasting peace.

What Gutting USAID Means for My Young Patients in Burundi “To my patients and their mothers, I offered apologies from the American people,” writes Dr. Jennifer Furin.

This is a gut-wrenching, beautifully written essay. A doctor must watch helplessly as children die because USAID's freeze on aid has limited access to nutritional supplements. time.com/7258248/us-f...

Very important to get this word out!

Bacterial Virulence study section was cancelled this morning. The email was sent 2 hours before the meeting start time. I feel terrible for the investigators 😡

Please don’t stop sharing and posting your science because of the current attack on it, it is still valuable and reminds us what the fight is for

Perspectives: International Day of Women and Girls in Science Today we celebrate International Day of Women and Girls in Science. To help commemorate this awareness day, this perspectives article showcases 6 women scientists from different counties that talk…

Today marks the 10th anniversary of the International Day of Women and Girls in Science (#IDWGS)! 👩‍🔬 🔬 🌍 #WomenInScience

Now more the ever, we value the importance of raising the profile of women and girls engaging with and contributing to science.

SA health research facing catastrophic financing cuts Cuts to United States funding of health research could have “catastrophic” consequences, says Professor Ntobeko Ntusi, who is at the helm of the country’s primary health research funder. He says the S...

"People in the US are now able to access long-acting HIV prevention shots, largely because of research that was conducted in SA and Uganda. Research in SA has also been critical to validating new TB treatments that are currently the SOC across the world."

www.spotlightnsp.co.za/2025/02/11/s...

Terrible, research will not be sustainable in the US

And a big shoutout and thanks to @joanneflynn19.bsky.social and her team for the incredible and critical NHP work!

Thank you! These are products of fantastic collaborations with amazing colleagues.

Interested in Mtb pathogenesis and developing new strategies to treat these deadly infections? Please apply to join us for the GRC for Tuberculosis Drug Discovery and Development!! www.grc.org/tuberculosis...
Deadline to submit an abstract to be considered for a talk is March 1st! Please repost!

Happy holidays from the IMP program! We celebrated the conclusion of the fall quarter with rotation talks by our brilliant first year class, pictured here with proud rotation mentors and program leadership! We’re excited to see what this group accomplishes in 2025!!

Miss you, Claire!

Tiago, thank you!

There will be many more… 👍