Julien Vaubourgeix

Transcription co-inhibition alters drug resistance evolution and enhances Mycobacterium tuberculosis clearance from granulomas - Nature Microbiology Targeting two distinct steps of the transcription process yields synergistic antibiotics that kill non-replicating Mycobacterium tuberculosis and reduce drug resistance.

Does this create an Achilles’ heel, and can you drug it? Turns out: yes.

Congrats to Barbara, Vanisha, Liz, and the rest of the team.

www.nature.com/articles/s41...

Go for it!

📢 We're searching for a PhD-level Senior Research Scientist to develop a next-generation antibacterial drug discovery strategy for Gram-negative infections.

If you're looking to combine CRISPRi and high-throughput assays, reach out to me by email or apply below.

www.linkedin.com/jobs/view/43...

Join our community of more than 120 ambitious research programmes in infectious disease, chemical biology, and many other areas of biomedicine - all under one roof with fantastic facilities and support.

📆 Deadline: 14 November.
🩺 Doctoral Clinical Fellows programme (3-year PhD)
🤝 Exciting collaboration with the amazing @jeanninehess.bsky.social
Curating bioactive chemical space in pathogenic bacteria using accumulation signatures across species
✍️ Apply here: www.crick.ac.uk/careers-stud...

📆 Deadline: 5 November.
Charting an atlas of bioactive chemical space in pathogenic bacteria
How can we computationally design experiments to more quickly discover new chemical probes and antibiotics?
✍️ Apply here: www.crick.ac.uk/careers-stud...

PhD students Our PhD programme attracts the brightest scientific minds and is an opportunity for talented people to embark on their career in biomedical research.

📢 PhD Opportunity @crick.ac.uk

Want to help fight against antimicrobial resistance? Join us in London! Open to international applicants.

We have non-clinical & clinical PhD positions to accelerate antibiotic discovery across bacterial species.

November deadlines. More details ⬇️🧵

National Academy of Medicine to Present Hamburg Award to Carl F. Nathan for Seminal Discoveries That Improve Understanding of Innate Immunity - NAM WASHINGTON — The National Academy of Medicine (NAM) today announced that Carl F. Nathan is the recipient of the 2025 David and Beatrix Hamburg Award for

Congratulations to JEM Editorial Board Co-Chair Carl Nathan on receiving the 2025 David & Beatrix Hamburg Award from @nam.edu for his fundamental work in improving understanding of #InnateImmunity:

Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization Capsid-forming PICIs (cf-PICIs) produce their own capsids and exploit phage tails from unrelated species to transfer their DNA across bacterial hosts. This tail piracy enables broad dissemination and ...

Thrilled to share our two latest papers with the @tcostalab.bsky.social
lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species.
@imperialcollegeldn.bsky.social
www.cell.com/cell/fulltex...

Kilometr'AAC - Apps on Google Play Automatic tracking of kilometers in accompanied driving.

J'en avais besoin alors j'ai codée l'app Android !

Ma fille est en #ConduiteAccompagnée et elle doit noter tout le temps les kilomètres parcourus.
C'est pénible et souvent on oubliait.

Donc voilà, j'ai créé #KilometrAAC pour Android qui fait tout ça pour vous !

play.google.com/store/apps/d...

Awesome stuff, Severin!

Stress-Induced Iron-Sulfur Cluster Damage as a Conserved Trigger of the Stringent Response Pathogenic bacteria rely on the stringent response to adapt to the complex and fluctuating conditions encountered within the host. However, the mechanisms by which the stringent response senses host-i...

Happy to share our lastest story about the Stringent Response ! We show how host-relevant stress disrupts Fe-S cluster stability, tuning (p)ppGpp levels to control bacterial adaptation and trigger virulence.
Read more here 👉 www.biorxiv.org/content/10.1...

"In TAG’s view, the suspended TB studies do not pose a substantial risk to the American public in comparison with the clear and present danger of TB, which is the world’s leading cause of death from a single infectious agent."

www.treatmentactiongroup.org/statement/tr...

Offre de thèse disponible dans notre équipe au @mmsb-lyon.bsky.social
Si vous êtes étudiant(e) en Master 2 et intéressé(e) par la génétique bactérienne, microscopie à épifluorescence et biochimie, contactez-nous et postulez à l'offre!
Dossier pour le 13/06
Concours école doctorale E2M2: 8 et 9/07.

Challenging times for biomedical research in the U.S. One of our grants was terminated and two others frozen. Thinking of colleagues from Bethesda to Boston to South Africa who are facing the same uncertainty. Now more than ever, we must speak up for the value of this work.

Excited to share our last study. Huge congrats to Sarah Monard, Arnaud Métais, @gclugo.bsky.social, @chrisverollet.bsky.social and all colleagues!
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇

shorturl.at/x4Sb5

Truly delightful to see the two of you together— reminds me of a different time, miles away.

Lucky you, Luiz!

Join our Infectious diseases & antimicrobial resistance workshop !
Registration form : www.ipbs.fr/mira-worksho...
Programme and details : www.ipbs.fr/mira2025/

#AMR #WAAW #AntimicrobialResistance #PublicHealth #Antibiotics #Tuberculosis #healthcareinnovation

PhD studentship: Structural and functional characterisation of mycobacterial outer membrane proteins at Newcastle University on FindAPhD.com PhD Project - PhD studentship: Structural and functional characterisation of mycobacterial outer membrane proteins at Newcastle University, listed on FindAPhD.com

First post of the year to mark my return from maternity leave :) Excited to share the first open PhD position in my group.
Deadline end of February.
Please spread the word. www.findaphd.com/phds/projectdetails.aspx?PJID=181239

Thoughtful and kind. Love it.

Congrats all!

Why does Acinetobacter lwoffii not become resistant to antibiotics? at University of Birmingham on FindAPhD.com PhD Project - Why does Acinetobacter lwoffii not become resistant to antibiotics? at University of Birmingham, listed on FindAPhD.com

Another PhD opportunity in the team! This time its an exciting collaboration with @halllab.bsky.social and @kimhardie.bsky.social looking at why not all bacteria become resistant! www.findaphd.com/phds/project... Deadline 10th Jan and open to Uk and overseas! Pls repost!

The @ukri.org #TARGetAMR #Network is supporting
#WHO: World #Antimicrobial #Resistance Awareness Week #WAAW2024 #AMR #Genomics #AMRAwareness #DrugResistance. Join us on our mission: targetamr.org.uk

Please add me to the club— thanks

Let's increase #klebclub chatter on 🔵🦋!
Klebsiella aficionados add your handle below and we will build a starter pack.

🔁 to spread the word

Can colleagues amplify this appeal to journals and journal editors to open accounts on Bluesky, please? @MicrobioSoc @TrendsMicrobiol @CellCellPress @JBacteriology @jbiolchem @Nature @ScienceMagazine @PNASNews @MolMicroEditors @NAR_Open @NatureMicrobiol @NatureComms @ASMicrobiology 🙏
🦠🧪🧫🧬

Congratulations to all. Beautiful work.