Olivera Francetic

A ubiquitin-like protein controls assembly of a bacterial type VIIb secretion system Cryo-EM structure reveals how a ubiquitin-like protein orchestrates assembly of a bacterial weapon system.

Our latest T7SS study is now out in Science Advances!
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.

www.science.org/doi/10.1126/...

YouTube video by The King's Singers Music for a while (Purcell) - The King's Singers & Jakub Józef Orliński

Can't stop listening to this divine piece
youtu.be/ZYBliPhLAE0?...

The PDZ domain of EpsC is required for extracellular secretion of VesB by the Type II secretion system in Vibrio cholerae | Journal of Bacteriology The T2SS is common in Gram-negative pathogens, facilitating the secretion of various toxins and enzymes; however, the mechanisms of substrate selection and secretion remain poorly understood. Here, we...

Congrats to the @sandkvistlab.bsky.social on this insightful
paper ! Journal of Bacteriology journals.asm.org/doi/10.1128/...

Bypassing BamD essentiality by mutations in a non-essential substrate | mBio The β-barrel assembly machinery (Bam) complex assembles all outer membrane proteins (OMPs) and is conserved and essential across all gram-negative bacteria. While BamA is critical for the folding and ...

Very interesting work freshly out in @mbio.bsky.social by the
‪@annakonovalova.bsky.social‬
lab journals.asm.org/doi/full/10....

An inner membrane protein is covalently attached to peptidoglycan in the γ-proteobacterium Dickeya dadantii Communications Biology - In Gram-negative bacterium Dickeya dadantii, an inner membrane protein OutB is covalently attached to peptidoglycan by the same catalytic mechanism as Braun’s...

Congratulations to Vladimir Shevchik and all the coauthors!
rdcu.be/exonh

A Single‐Plasmid Inducible‐Replication System for High‐Yield Production of Short Ff (f1, M13 or fd)‐Phage‐Derived Nanorods Single-plasmid inducible-replication system for biological nanorod production was developed based on the knowledge of replication and biology of the Ff (f1, fd or M13) bacteriophages from which they ...

See our new paper describing a simple single-plasmid system for making <100 nm filamentous phage-derived nanorods, based on a PhD thesis by Rayen Leon-Quezada at Massey University, collaboration with @the-gold-lab.bsky.social
#phage
enviromicro-journals.onlinelibrary.wiley.com/doi/full/10....

Magnifique et bouleversante Mélody Gardot pour son dernier concert à l’Olympia… 💜

PhD position in Molecular Biology We are looking for a PhD student in Molecular Biology and a special interest in microbial evolution and ecology. The position at the Department of Molecular Biology at Umeå University is temporary fo

We have a salaried 4-year PhD student position available in the Lind Lab at Umeå University, Sweden! Exploring the eco-evolutionary dynamics of salt-induced cell clustering in bacteria. Reposts appreciated. umu.varbi.com/en/?jobtoken...

In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...

#Kintsugi. If you break your favorite vase or cup, don't throw it away. With Kintsugi its life will continue, more beautiful and more precious than before. Many thanks to Michiyo Yamashita, who teaches this ancient Japanese art in Paris.

The Journées Sécrétion are back!

2nd and 3rd October in Marseille

Keynote lecture by: @archaellum.bsky.social

Registration is open until May 15: forms.gle/2qxHntTktoxw...

Organized by Romé Voulhoux @lcbofficiel.bsky.social, @cascaleslab.bsky.social, Thierry Doan, @juliengiraud.bsky.social

Moi aussi, ça m'a fait un choc. La deadline est le 27 mars.

❗️Exciting upcoming post-doc opportunity in the lab❗️🔔 If you have expertise in cryo-EM and bacterial secretion systems are your thing, then I’ll soon be advertising a long-term position funded by Wellcome Trust. Feel free to DM or email for early enquiries.. Thanks!

Diversity, Diversidad, Diversität... Noteworthy — We are living through interesting times, to say the least. Not long ago, though now it may feel that it's been eons, we could freely celebrate microbial diversity, biodiversity, structura...

schaechter.asmblog.org/schaechter/2...

Call for applications 2025 - Creation of new research groups at the Institut Pasteur - Research The Institut Pasteur launches an international call to recruit new junior research group leaders in the application of cutting-edge transdisciplinary approaches to the exploration of host-microbe, tis...

The Structural Biology and Chemistry Department at Institut Pasteur is seeking a junior or mid-career researcher to lead a new group in Medicinal Chemistry, Chemical Biology or Structural Biology
research.pasteur.fr/en/call/call...

A human gut bacterium antagonizes neighboring bacteria by altering their protein-folding ability Antagonism shapes microbiomes. Lim et al. identify a mechanism used by human gut commensals to antagonize related bacteria. The secreted effector Bte1 alters the protein-folding machinery of targeted ...

A human gut bacterium antagonizes neighboring bacteria by altering their protein-folding ability: Cell Host & Microbe www.cell.com/cell-host-mi...

Re: Limitations of LB Medium by Christoph — Say, you are a student in a molecular genetics lab course or a more advanced cloning expert, you will inevitably have to deal with E. coli. And to make E. coli bacteria grow quickly, st...

Re: Limitations of LB Medium

Read more > schaechter.asmblog.org/schaechter/2...
#MicroSky

Allopurinol use and risk of multiple sclerosis Multiple sclerosis (MS) is a chronic, immune-mediated neurological disease characterized by inflammation, demyelination, and neurodegeneration within the central nervous system (Attfield et al., 2022)...

Low uric acid levels could be linked to an increased risk of multiple sclerosis www.msard-journal.com/article/S221...

We are pleased to announce that ETOX 2025, the 22nd European Workshop on Bacterial Protein Toxins, will be held in Spain, June 29 - July 3, 2025. Registration opens on January 6. Apply here etox-meetings.org and join us for a great meeting! Please repost

KlebPhaCol

Hi Klebsiella researchers! We are excited to share KlebPhaCol, a barrier-free, #opensource and expandable #Klebsiella #phage and strain collection for your research. #KlebPhaCol currently contains 53 phages and 74 strains to request, use and share!
www.klebphacol.org