Andrew Yu

Thought provoking debate:

Are you pro-AI vs pro-MELD for organ allocation?

journals.lww.com/lt/abstract/...

journals.lww.com/lt/abstract/...

#Livertwitter

This trend is *very* concerning given that alcohol damages the liver of females at 2x the rate of males. We are seeing so many young females (20s and 30s) who get very sick and often die from🍸🍷🍻-associated liver disease!

We need to work on strategies to 📉 alcohol use in this population! #liversky

A cascade of unnecessary tests - and their harms

Patient with ALL and stem cell txp
has varices
But HVPG was ⬇️
So had EUS-PPG with ⬆️ HVPG but caused portal thrombosis
Eventually starts carvedilol

Rewind
1. Classic story for NRH
2. Found varices, pressures not needed
3. Just start coreg
#liversky

Advisory Committee on Immunization Practices (ACIP) ACIP develops recommendations on how to use vaccines to control disease in the United States.

Remember how I keep telling y'all to stay updated on ALL of your vaccines?
Well the ACIP specific guidance on individual vaccines has been taken down.
Pediatricians and primary care providers use these guidelines EVERYDAY!
www.cdc.gov/acip/

How Will Trump's Executive Orders Change Government? What the New Orders Mean for a New Order

New, from me: A breakdown of the most important Trump orders for government employees, the delivery of public services, and state capacity
Including DOGE, Schedule F, return to office, hiring freezes, more politicization and investigating government employees. 🧵
open.substack.com/pub/donmoyni...

Things We Do for No Reason™: Avoiding naltrexone for alcohol use disorder in liver disease Hospitalizations related to alcohol use disorder (AUD) are common. Yet, few patients receive pharmacotherapy consistent with guideline recommendations. Previous concerns over the potential hepatotoxi...

Great summary of evidence for safety of naltrexone in liver disease 👇

It's that time of the year again. In no particular order, I would like to share a few of #livertwitter in 2024 with #liversky

These could be original research, guidance statement, position paper or editorial. This is def not an inclusive list. Feel free to add to the 🧵

The steatotic liver disease burden paradox: unravelling the key role of alcohol - Nature Reviews Gastroenterology & Hepatology Steatotic liver disease (SLD) encompasses a spectrum of hepatic lipid-accumulation disorders, including metabolic and alcohol-related liver disease. This Perspective introduces the ‘SLD burden paradox...

New in #NatureReviewsGastroHep - this Perspective on the steatotic liver disease burden paradox and the key role of #alcohol
By Nikolaj Torp, Mads Israelsen & Aleksander Krag
www.nature.com/articles/s41...

Free to read: rdcu.be/d2x1o

#MASLD #liversky #metALD

Tirzepatide for Obesity Treatment and Diabetes Prevention | NEJM Obesity is chronic disease and causal precursor to myriad other conditions, including type 2 diabetes. In an earlier analysis of the SURMOUNT-1 trial, tirzepatide was shown to provide substantial a...

3-yr data for SURMOUNT-1: up to 20% TBW loss w/ #tirzepatide @elilillyandco.bsky.social
15 mg dose maintained. 94% risk reduction in diabetes among prediabetics. Mostly GI AEs almost all in first 20 weeks.
#liversky

#EsophagealStenting isnt technically challenging

But several factors to consider

✅ Stent Diameter Select
✅ TTS vs Fluoro guided stents
✅ Stent fixation
✅ Benign vs Malignant

Great work by #JensonPhung sharing practical tips in #Foregut journal

📎 journals.sagepub.com/doi/abs/10.117…

🚨AGA New Guideline Alert🚨
🔗https://tinyurl.com/4dr3y5ms

▶️AGA Living Guideline: Pharmacological Management of Moderate-Severe Ulcerative Colitis
I’ll break down its 14 recommendations down over the next 9 tweets 🧵 👇

#AGA #GI #UC #IBD
1/9

Really fantastic Starzl lecture by Dr. Lisa Van Wagner about life after transplant and survivorship!

Some Resmetirom considerations @SonalKumarMD for #MASLD #MASH at #TLM24

🟢 Dosing is weight-based
🔴 Beware of drug interactions: Gemfibrozil, Plavix, and statins
🔵 Mostly GI side effects, mostly short-lived

Wondering why vasoconstrictors work in hepatorenal syndrome even though the pathogenesis is driven by renal vasoconstriction? Here is a conceptual explanation:

Thought provoking presentation from Renu on the topic of hepatologists and HCC management #TLM24
@atoosarabiee.bsky.social we need to get Renu here on blue sky!

Types of pancreatic cysts.

- morphology (MRI/EUS)
- cytology/histology (EUS)
- cyst fluid analysis (EUS)

#MedSky #RadSky #GISky

Phil Newsome presents the much-anticipated ph 3 ESSENCE trial of semaglutide in MASH—data shown are for the week 72 interim analysis, involving 800 participants #TLM24 #LiverSky

ALD and MASLD are a lot alike. How do we tell them apart on pathology?

Cindy Behling walks us through in this fantastic talk. 👏

#TLM24 #Liversky @juanpabloarab.bsky.social
#pathologysky