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Justin Lines

@jlines.bsky.social

Neuroscientist. Plays with microscopes and ECoG to study network activity in health and disease. Postdoc in the lab of Denise Cai. I also 🎮 and ⛹️

106 Followers  |  137 Following  |  2 Posts  |  Joined: 25.11.2024  |  1.5702

Latest posts by jlines.bsky.social on Bluesky

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It has been an immense honor to learn & grow with two of the greatest scientists I know: @zachtpennington.bsky.social & @joezaki.bsky.social 🧑‍🔬

Listen in on our conversation about mentorship, building trust and creating a safe space to disagree: neuronline.sfn.org/professional...

03.10.2025 20:33 — 👍 16    🔁 4    💬 1    📌 2

Excited to share that I landed my dream job!🎉🎉🎉 The Pennington Lab will be opening at the University of British Columbia in January 2026!
@ubcpsych.bsky.social @dmcbrainhealth.bsky.social

29.09.2025 16:31 — 👍 148    🔁 29    💬 29    📌 5
Screenshot of article entitled "Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy" by Yu Feng, Keziah S. Diego, Zhe Dong, ..., Nadia N. Khan, Denise J. Cai, and Tristan Shuman. In brief: Feng et al. demonstrate that memory deficits in temporal lobe epilepsy involve multiple discrete mechanisms with distinct time courses. In epileptic mice, early-onset memory deficits are associated with disrupted hippocampal synchronization, while more severe, lateonset impairments are associated with disrupted synchrony of medial entorhinal cortex circuits.

Screenshot of article entitled "Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy" by Yu Feng, Keziah S. Diego, Zhe Dong, ..., Nadia N. Khan, Denise J. Cai, and Tristan Shuman. In brief: Feng et al. demonstrate that memory deficits in temporal lobe epilepsy involve multiple discrete mechanisms with distinct time courses. In epileptic mice, early-onset memory deficits are associated with disrupted hippocampal synchronization, while more severe, lateonset impairments are associated with disrupted synchrony of medial entorhinal cortex circuits.

New paper out in Cell Reports! Led by @susieyufeng.bsky.social, we found that chronic epilepsy in mice drives distinct synchronization deficits in hippocampus and MEC, with early changes in HPC and late-onset changes in MEC that align with progressive memory impairment.
www.cell.com/cell-reports...

28.01.2025 20:17 — 👍 52    🔁 21    💬 1    📌 1
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A spatial threshold for astrocyte calcium surge In astrocytes, there exists an intrinsic spatial threshold of subcellular calcium levels that triggers an astrocyte calcium surge throughout the cell, demonstrating cellular astrocyte calcium integrat...

Astrocyte physiologists and computationalists!

Imaging astrocyte structure and function, we discovered and quantified a spatial threshold to astrocyte calcium surge ⭐

doi.org/10.7554/eLif...

20.01.2025 13:53 — 👍 8    🔁 1    💬 0    📌 0
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❓ Do you know what the anterior hypothalamic nucleus (AHN) does? No? Neither did we! 🧠

In a new preprint from the Cai Lab, learn how we discovered the AHN’s central role in regulating stress vulnerability.

Read the paper here: www.biorxiv.org/content/10.1... (1/6)

22.11.2024 19:32 — 👍 67    🔁 22    💬 5    📌 5

SO EXCITED to share our latest work demonstrating that the anterior hypothalamic nucleus (AHN) regulates stress vulnerability!!!

22.11.2024 20:16 — 👍 50    🔁 20    💬 3    📌 0
Nature paper article with title and abstract

Nature paper article with title and abstract

🌟 Cai Lab Nature (@natureportfolio.bsky.social) paper alert! In work led by Joe Zaki, we find that rest periods after learning not only stabilize new memories BUT ALSO integrate new memories with older ones from days past! (1/10)

Read it here: www.nature.com/articles/s41...

19.11.2024 16:49 — 👍 260    🔁 91    💬 8    📌 4
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Just showing off some growth

28.11.2024 16:07 — 👍 2    🔁 0    💬 0    📌 0

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