David Posner, PhD

Replaying evolution to learn about the fitness landscape of affinity maturation A five year collaboration with the Victora lab is bearing fruit for evolutionary biology.

Over the past 5+ years I've had the honor of working with @wsdewitt.github.io @victora.bsky.social and many others on a project to "replay" affinity maturation evolution from a fixed starting point.

matsen.group/general/2025...

Abcam are a safe bet! Ive only used rabbit im afraid.

Intestinal plasma cells get in formation IgA plasma cells are the most abundant antibody-secreting reservoir in the body, yet details of their origin and behavior remain elusive. In this issue of Immunity, Simons et al. and Siniscalco et al....

My latest 'pinch yourself' moment from the Lab. We previewed two really really exciting papers from the Eisenbarth and Pabst Labs for @cp-immunity.bsky.social
Read our summary here> www.cell.com/immunity/ful...
A big well done to Gaby Berman in my group and authors of both excellent manuscripts!

Stroke scientists gather more evidence for presence of ‘gut-brain axis’ Research on mice by scientists at The University of Manchester has shed new light on why the guts’ immune system changes after a stroke and how it might contribute to gastro-intestinal problems.Publis...

www.manchester.ac.uk/about/news/s...

Cerebral ischaemic stroke results in altered mucosal antibody responses and host-commensal microbiota interactions Stroke is a devastating neurological event with a high risk of mortality that results in long-term sequalae that extend beyond the central nervous sys…

New paper out! @hepworth-lab.bsky.social looks at how stroke affects intestinal humoral immunity!

www.sciencedirect.com/science/arti...

Listening to the new Taylor Swift album & working on figures, sharing a 🤩 image for #FluorescenceFriday

[penetrating 🐭 cerebral arteriole at the pial surface, aSMA in yellow = smooth muscle cell, pan-laminin in cyan = basement membrane, fibroblast in magenta...squeezing in to cover that vessel 🫂)

Julie this is just the best! Happy TS release day

Check out her brilliant tweet breaking the paper down here: x.com/elizabetha_c...

Childhood brain tumours instruct cranial haematopoiesis and immunotolerance Recent research has revealed a remarkable role for immunosurveillance in healthy and diseased brains, dispelling the notion that this organ is a passive immune-privileged site[1][1]–[3][2]. Better und...

The outstanding Elizabeth Cooper from @gilbertsonlab.bsky.social just shared a new preprint!! Using cutting-edge tech and models, she found that brain tumours instruct cranial haematopoiesis allowing immunotolerance of childhood brain tumours and CNS development. www.biorxiv.org/content/10.1...

The Source of Firefly Chemical Defenses: Endogenous Biosynthesis of Lucibufagins from Cholesterol Fireflies, also known as lightning bugs, are beetles in the family Lampyridae. Several species of North American fireflies have been investigated to determine their toxic components. The primary molec...

Happy to see this published over 10 years after working on it! It was a fun project back in my undergrad days in NY. Using 2D NMR we provide the first direct evidence that fireflies utilise dietary cholesterol to generate lucibufagins, their chemical defense system.
pubs.acs.org/doi/10.1021/...

We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...

Equity in science is a beautiful lie — and I’m done pretending Science isn’t really moving towards equity; institutions are just perfecting the appearance of equity. We need to build an alternative system.

Science isn’t really moving towards equity; institutions are just perfecting the appearance of equity. We need to build an alternative system, says Dolors Armenteras

go.nature.com/4nzGhp9

Intestinal challenges shape the polarisation of protective dural memory CD4 T cells The meninges house several innate and adaptive immune cell populations[1][1]–[3][2]. These predominantly localise within the dura mater and include gut-derived IgA-secreting plasma cells[4][3]. Whethe...

New paper alert! 🎉 Check it out here: biorxiv.org/content/10.1... Here we show that intestinal bacterial, helminth and fungal challenges polarise CD4 T cell populations in the dural meninges.

Just back from Basel after an inspiring week at the EMBO Tissue Immunity workshop 🧠🫁🧑‍🦲. I loved giving a flash talk and hearing so many exciting ideas on barrier immunity. Huge thanks to @hepworth-lab.bsky.social for supporting my participation!

Petition: Review all trade ties with Israel, suspend 2030 roadmap & impose trade sanctions We call on the Government to review existing trade ties with Israel, suspend the 2030 Roadmap for UK-Israel bilateral relations and impose trade sanctions upon Israel.

Please sign this Parliamentary petition calling for comprehensive trade sanctions on Israel - the limited sanctions on specific members of the Israeli Government by the UK do not go far enough: petition.parliament.uk/petitions/72...

a yellow sign that says we 're hiring ALT: a yellow sign that says we 're hiring

Spread the news! We are excited to expand our research team, working on cellular senescence, at the Cancer Research UK Cambridge Institute, University of Cambridge.

jobs.cam.ac.uk/job/52026/
jobs.cam.ac.uk/job/52027/

Fenestrated endothelium enables the extravasation of immune complexes into the synovium. There the interaction of macrophages (producing IL1b, CXCL1) and nociceptive neurons (producing CGRP) induce pain and inflammation.

Hasegawa &al 2024
www.nature.com/articles/s41...
#RheumSky 🧪⑂

Gut microbiota-derived hexa-acylated lipopolysaccharides enhance cancer immunotherapy responses - Nature Microbiology Hexa-acylated lipopolysaccharides from the gut microbiota are associated with efficacy in patients with cancer receiving anti-PD-1 and stimulate host immune activation for enhanced anti-tumour immunit...

New paper from Virginia Pedicord's lab just dropped! www.nature.com/articles/s41...

There’s no place like home: How local tissue microenvironments shape the function of innate lymphoid cells Innate lymphoid cells (ILC) have emerged as critical immune effectors with key roles in orchestrating the wider immune response. While ILC are relativ…

The pre-proof version of our new review is online now at @mucosalimmunol.bsky.social. @lukeocyte.bsky.social and Alanna Kelly (not on Bluesky) deep dive into ILC niches, and discuss how cellular interactions, nutrients and ECM shape our innate immune system!
www.sciencedirect.com/science/arti...

The meninges host a distinct compartment of regulatory T cells that preserves brain homeostasis Meningeal regulatory T cells restrain local interferon-γ–producing lymphocytes, thereby safeguarding parenchymal brain homeostasis.

A #Science #Immunology Instant Release:
@mmr2.bsky.social, Diane Mathis, & colleagues at @harvard.edu & @institutocajal.bsky.social describe specialized meningeal #Treg subsets that promote #homeostasis of the mouse #brain #meninges & #parenchyma!

Well done Steph! 😁

PhDone!!! So happy that I PASSED my viva! Major thx to outstanding examiners @juanquintana.bsky.social and @immunoah.bsky.social for giving me a run for my money 🥳. The biggest thx is to the people below, who made it all possible 😘. @mrclmb.bsky.social @caiuscollege.bsky.social Ready for postdoc!

How I’m creating career opportunities for researchers back home in Mexico David Posner hopes that his teaching and outreach programmes could apply to other low- and middle-income countries.

I've always been passionate about outreach and social justice, especially when in science.

I wrote this article @nature.com to inspire others to generate similar initiatives. nature.com/articles/d41586-024-03562-4

I'll be sharing a new large-scale programme I'm launching soon. Stay tuned!

Please join us for our January #GDTcellClub #gdTcells webinar with talks by Drs. Pedro Papotto and Victoria Stary.

Jan 16 @ 12pm (New York) | 5pm (London)

nyulangone.zoom.us/j/9589051706...

Zoom ID: 958 9051 7066
Passcode: 369081

@payalyokota.bsky.social @ph-papotto.bsky.social

Exciting new pre print out now from @ph-papotto.bsky.social and @profjudiallen.bsky.social...
Bluesky-orial below!

My first week in my new job is done! Let's see what's next 😎

I'm so excited to announce that I've joined the @hepworth-lab.bsky.social in Manchester for my postdoc! So pumped to finally be here and ready to get some science done 🤩💪 @lydiabeckeriii.bsky.social