Mitchell Bijnen

Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart Respiratory infection and cardiovascular disease risk are tightly intertwined clinically, but the mechanisms of this relationship are largely unknown. Here, Downey et al. reveal how influenza traffics...

Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart: Immunity www.cell.com/immunity/ful...

A woman by a flipchart during a course. Text highlighting the EMBO Lab Leadership for group leaders online course 23 – 25 March still has places available

Places still available on @embo.org lab leadership for group leaders online course 23–25 March. Take the time to master your interpersonal skills, unlock tools for team growth, and elevate your communication style. Sign up now: www.embolableadership.org/course/embol... #EMBOLabLead #PI #GroupLeader

Hidalgo Lab | Mapping Innate Immunity Research on neutrophil biology, innate immunity, and cardiovascular disease at Yale School of Medicine. Led by Dr. Andrés Hidalgo.

I am excited to present our long-overdue lab website. Please visit us to learn who we are, our past work, and our current lines of research!
ahidalgolab.com

Thank you to Gerardo Barcia for his beautiful design and constant support in building it

OBS Neuroimmunology Webinar, monthly on the 3rd Thu at 12 PM ET!
🧠 Inhibition of ACAT 1 promotes shedding of soluble TREM2 and LRP1-dependent phagocytosis of amyloid beta protein in microglia
🔬 Speaker: Moriah Hovde (MGH)

💻 Zoom: us02web.zoom.us/meeting/regi...

Scientific lectures: Morgane THION | Paris Brain Institute Speaker : Morgane THION, College de France"Microglia in the developing brain: from colonization to functions"

🎙️ Morgane THION, Collège de France, will talk about "microglia in the developing brain: from colonization to functions" on Monday, 9 February, at 11am at Paris Brain Institute.

👉 More information: https://parisbraininstitute.org/agenda/scientific-lectures-morgane-thion

Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis - Nature Immunology Sabatino and colleagues examine expanded CD8+ T cell clonotypes from a small cohort of multiple sclerosis patients. They identified several cognate peptide epitopes that derive from Epstein–Barr virus...

Overjoyed to share our new work exploring the antigen specificity of CSF-expanded CD8+ T cells in #multiplesclerosis #EBV in @natimmunol.nature.com #immunology 🧪🧵1/

www.nature.com/articles/s41...

📢 Our latest work is now in press at @natcomms.nature.com! A great collaboration with the Schultze lab @dzne.science & Denali Therapeutics, to identify molecular and functional changes associated with TREM2 signalling in microglia, with implications for TREM2 agonism.. www.nature.com/articles/s41...

Meningeal blood vessel blockage enhances anti-glioblastoma immunity www.cell.com/cell/fulltex...

This week in #preprinthub1, Aislinn Keane from Mt.Sinai will present a preprint from Patrick Süß lab titled "Csf1r-mediated depletion of midbrain microglia prevents dopaminergic neuron loss during chronic colitis"

biorxiv.org/content/10.6...

(1/5) 🚨 The ySPI Winter Webinar is coming!
We’re kicking off the 2026 season with Inês Lorga, who’ll share her research on how the immune system shapes brain infection and development in early life 🧠🦠

Scientific Editor, Cell Cell has an opening for a full-time scientific editor. If you are a passionate, mission-driven team player who loves thinking broadly about science and wants to have a positive impact, we invite you t...

Cell is hiring!

Do you have a background in #neuroscience or #immunology? Better still, #neuroimmunology? Cell has an opening for a full-time scientific editor. Role will be based out of any one of our offices in Medford, MA, UK, Spain, Netherlands, China tinyurl.com/4ma236xn @cp-cell.bsky.social

Dissecting surveying behavior of reactive microglia under chronic neurodegeneration In chronic neurodegeneration associated with prion disease, reactive microglia adopt a highly mobile, neuron-by-neuron surveillance strategy, replacing homeostatic process-based monitoring with dynami...

Dissecting surveying behavior of reactive microglia under chronic neurodegeneration

elifesciences.org/articles/107...

@biorxivpreprint.bsky.social Functional border-associated macrophages limit Alzheimer's Disease progression
www.biorxiv.org/content/10.6...

A Common Iba1 Antibody Labels Vasopressin Neurons in Mice There are a wide variety of commercially available antibodies for labeling microglial cells based on different protein targets, as well as antibodies for the same protein target made in different spec...

PSA for all #microglia lovers: certain Iba1 antibodies (see our new paper below for details) label not only microglia, but also vasopressin neurons, at least in mice. Brain region and species matter. A friendly reminder to always validate your antibodies! 🔬

www.eneuro.org/content/13/2...

Don't miss the 2026 Global Immunotalks!

Join us for the 2026 GRC Immunochemistry and Immunobiology "Immune Circuitry and Molecular Pathways in Tissue Homeostasis, Infection, and Disease" in beautiful Barcelona. June 28 - July 3, 2026. Great lineup of speakers! www.grc.org/immunochemis...

Intestinal macrophages modulate synucleinopathy along the gut–brain axis - Nature Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understa...

Intestinal macrophages modulate synucleinopathy along the gut–brain axis www.nature.com/articles/s41...

Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammatory mediators and late-onset Alzheimer’s disease risk factors @cp-immunity.bsky.social www.cell.com/immunity/ful...

Happy to announce our very first SMyLe seminar. Please join us for this exciting talk entitled "Transcriptional regulation of neutrophil plasticity in cancer" by Dr. Máté Kiss @matekiss.bsky.social on February 17th at 16.30 at ETH Höngg (HCI J6) or via Zoom (ethz.zoom.us/j/63706799264).

New preprint! Liver macrophages are highly autofluorescent cells, complicating analysis. @sabinedaemen.bsky.social developed a spectral flow approach to resolve #macrophage subsets in healthy vs #MASLD livers.
#FlowCytometry #SpectralFlow #Autofluorescence
doi.org/10.64898/202...

Immune cells adapt to distinct stem cell niches to govern tissue homeostasis https://www.biorxiv.org/content/10.64898/2026.01.28.701831v1

Happy to share our latest work on the epigenetic basis of trained immunity in hematopoietic stem cells! @bcmhouston.bsky.social @texaschildrens.bsky.social

@immunologyuoft.bsky.social

Targeting modulated vascular smooth muscle cells in atherosclerosis via FAP-directed immunotherapy Vascular smooth muscle cell (VSMC) diversification drives atherosclerotic coronary artery disease (CAD). Mechanisms governing these cell state transitions remain unclear. We applied multiomic single-c...

Discovery of an entirely new potential approach to atherosclerotic heart disease: targeted immunotherapy!
Studies in human coronary arteries to reduce plaque and the mouse experimental model. Another win for spatial multiomics @science.org
www.science.org/doi/10.1126/...

CD38 endows local antigen-specific Treg cells with stress resilience for control of compartmentalized CNS inflammation @natimmunol.nature.com
www.nature.com/articles/s41...

Read our new preprint highlight with @natrevimmunol.nature.com 👇

www.nature.com/articles/s41...

So great that this paper is finally out! Happy that I was able to contribute to this important study. Congratulations @seppedeschepper.bsky.social, @soyonhonglab.bsky.social, Tim Bartels and all co-authors!

Tumor-associated macrophages enhance peripheral nerve tumor infiltration and spinal cord repair Tumor-associated macrophages (TAMs) enhance cancer progression by driving angiogenesis, extracellular matrix remodeling, and immune suppression, yet their impact on nerve growth is unclear. Dolci and colleagues show that TAMs directly stimulate neurite outgrowth, revealing a dual role in enhancing intratumoral nerve growth and promoting neural repair after severe spinal cord injury.

Online now: Tumor-associated macrophages enhance peripheral nerve tumor infiltration and spinal cord repair

XPR1 regulates fetal liver #macrophage development, identity and pyrenocyte clearance, say Sebastian Stifter, Melanie Greter and colleagues: rupress.org/jem/article/...

📘 From #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...

Circulating Neutrophil and Monocyte Counts Are Inversely Associated With Heart Rate Variability Indices: The Maastricht Study | Journal of the American Heart Association

Happy to share our latest publication showing that higher neutrophils and monocytes, but not other leukocytes, were linked to lower heart rate variability — a sign of reduced flexibility in how the heart responds to daily demands.

www.ahajournals.org/doi/10.1161/...

#inflammation #cardiovasular