Mitchell Bijnen

🧬🍽️ Your macrophages may be carrying your mother’s metabolic history!
In our @cp-trendsimmuno.bsky.social article, we discuss how maternal diet programs lifelong immune function.
authors.elsevier.com/sd/article/S...
#ImmuneMemory #Macrophages #MaternalNutrition #DOHaD #EarlyLifeProgramming

'Lessons from ex vivo and in vitro models in microglia research'

by Csaba Cserép, Péter Berki, Mayte Mars, Balázs Pósfai, R. Jeroen Pasterkamp, Szilvia Benkő & Ádám Dénes

www.cell.com/trends/neuro...

Congratulations!

Congratulations Christoph! Great news!

The results of the ERC Consolidator Grant call have been announced! 📣

349 researchers have been selected for funding. Congratulations to all! #ERCCogG!

👉 buff.ly/uu62uFV

#FrontierResearch #EUfunded #HorizonEurope

@scienceinnovation.ec.europa.eu

DC subsets and states unraveled across human juxtatumoral and malignant tissues @natimmunol.nature.com
www.nature.com/articles/s41...

The evolution of microglia replacement: A new paradigm for CNS disease therapy Microglia are important immune cells in the brain. Mutations in microglia cause microgliopathies. Microglia replacement has emerged as a groundbreaking therapeutic paradigm that enables correction of ...

www.cell.com/cell-stem-ce...

Fresh from Elvira Mass Lab @masslab.bsky.social. We are happy to share our thoughts on how maternal malnutrition can shape the development of offspring tissue-resident macrophages during early development. Happy reading!

Brain’s ‘plumbing’ inspires new Alzheimer’s strategies—and controversial surgeries Animal studies support idea that boosting fluid clearance could blunt neurological disorders

Brain’s ‘plumbing’ inspires new Alzheimer’s strategies—and controversial surgeries @science.org
www.science.org/content/arti...

Allergies: central role of the "gut brain" discovered An international research team led by scientists from Charité – Universitätsmedizin Berlin and Bern has identified a previously unknown function of the intestinal nervous system.

Researchers led by 🇩🇪 Charité Berlin, 🇨🇭 @unibe.ch and 🇨🇭 @inselgruppe.bsky.social gained new insights into the intestinal nervous system – or "gut brain" – which may open new therapeutic avenues for #allergies, chronic inflammatory #bowel diseases and irritable bowel syndrome.

In vivo CRISPR screen reveals regulation of macrophage states in neuroinflammation @natneuro.nature.com
www.nature.com/articles/s41...

We’re excited to announce the launch of the Swiss Myeloid League (SMyLe), a new network uniting myeloid cell researchers across Switzerland. 🇨🇭

Our mission: foster collaboration and strengthen the Swiss myeloid community, locally and globally.

👉 Join our growing network: myeloid.ch

PILRA is a therapeutic target for Alzheimer’s disease that regulates neuroinflammation and metabolism in microglia
www.science.org/doi/10.1126/...

Today, we see the fruit of 5+ years of teamwork. We have built a map of the neutrophil compartment (mostly in mice - but also humans). It provides a biological structure that focuses on a single immune cell lineage to discover the many ways in which neutrophils "interpret" physiology.

Architecture of the neutrophil compartment @nature.com
www.nature.com/articles/s41...

Happy to see that our latest work about the role of XPR1 in fetal liver macrophages is now out in JEM!

WANTED A bioinformatician for the analysis of in-house produced multi-omic data. Guided by the Weizmann bioinformatics services, we aim to establish analysis and graphics pipelines. Proficiency in R / Python and statistical methodologies, as well as a basic understanding of biology, is required.

WANTED A qualified lab technician/manager to run the infrastructure of our ERC-funded laboratory, including a pipeline for expression profiling, and maintenance of animal colonies. We look for a detail-oriented, technically proficient , assertive, energetic, and curious individual.

Today I presented our data on sex differences in experimental #MASH development at the MASLD-EGIR Study group meeting in Pisa showing earlier #steatosis, #inflammation and glucose intolerance in females but more fibrosis in males. Great conference! @gastaldelli-amy.bsky.social

Local B cell maturation and mast cell regulation of choroid plexus function in early life. Postnatal development is a critical period for the maturation of the nervous and immune systems. The choroid plexus (CP) within the brain ventricles guides brain development through the production of ...

Excited to share our new preprint: “Local B cell maturation and mast cell regulation of choroid plexus function in early life” www.biorxiv.org/content/10.1... , initiated in the lab by Laetitia Travier and led by the one and only @fakesamir.bsky.social

Excited to share my final postdoc project published. We looked into the striking amyloidosis of important brain waste clearance sites (bridging veins) in mouse and human. A great collaborative project with Rupal Mehta at Rush who did all the human studies. Thanks to everyone who contributed!

Amyloidosis of bridging veins in AD mouse models and humans - clogged CSF exit routes. New in @jem.org from Smyth, Mehta, @jonykipnis.bsky.social @washumedicine.bsky.social and colleagues: rupress.org/jem/article/...

#Neuroinflammation #Alzheimers

Speakers Posted Online: 21st Int'l Conference on #InnateImmunity held in #Sissi #Crete #Greece from May 22-27, 2026 at #KalimeraKritiHotel Register and submit your abstract. www.aegeanconferences.org/src/App/conf...

Research Associate: In vivo technologies Research Associate Neuroscience at Roche in Basel supports in vivo studies and discovery work within NRD with focus on rodent models and translational research

Research Associate Vacancy in Neuroscience at Roche in Basel supports in vivo studies and discovery work within NRD with focus on rodent models and translational research. Closing date: 28th December

www.dementiaresearcher.nihr.ac.uk/job/research...

New webinar coming TODAY‼️
Jonas Neher from Biomedical Center Munich and the DZNE will be our next speaker on December 1st. Check all the information in the flyer and add it to your calendar! 🧠🧪

Beautiful work on postnatal meningeal B cell proliferation and instruction by local fibroblasts!

Microglial phagocytosis in Alzheimer disease Nature Reviews Neurology, Published online: 28 November 2025; doi:10.1038/s41582-025-01162-yGrowing evidence indicates important roles for microglial phagocytosis in Alzheimer disease. This Review summarizes the latest insights into the mechanisms by which microglial phagocytosis can affect Alzheimer disease pathology and how this process might be harnessed for therapeutic interventions.

New online! Microglial phagocytosis in Alzheimer disease

Review @natrevneuro.nature.com
Immune dysfunction in Alzheimer disease
www.nature.com/articles/s41...