Sounak Sahu

Congratulations @sseethar.bsky.social

Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification - Nature Communications BRCA1 and BRCA2 are well known breast cancer predisposition genes, however, many variants have not yet been classified for their pathogenicity. Here, the authors analyse a large combined cohort to pro...

1/🧬 Excited to share our latest paper in Nature Communications @natcomms.nature.com. We analyzed germline sequencing data from 400,000+ women to strengthen how we classify BRCA1 & BRCA2 variants.
🔗 www.nature.com/articles/s41...
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Proposed cut to NIH for fiscal 2026- $18 billion

www.whitehouse.gov/wp-content/u...

Comprehensive single-cell aging atlas of healthy mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and Cancer. #NatureAging #Aging #scisky #Medsky #News #Cancer

Open Access
www.nature.com/articles/s43...

Saturation genome editing-based clinical classification of BRCA2 variants - Nature CRISPR–Cas9-based saturation genome editing in a humanized mouse embryonic stem cell line was used for comprehensive functional characterization of single nucleotide variants in a region of BRCA2, and...

Excited to share our latest study in
@nature.com We used a humanized-mouse ES cell model to explore the functional consequences of all possible BRCA2 missense variants. We've clinically classified >6,500 variants and >1,200 reported in ClinVar! www.nature.com/articles/s41...

Gut lining in pregnant and lactating mice expands to ensure offspring health The RANK–RANKL pathway promotes intestinal epithelial expansion in pregnancy and lactation to meet increased nutritional demands.

“During pregnancy, several organs are rewired to support the health of the mother and the offspring. A molecular signalling pathway called RANK–RANKL drives the expansion of the layer that lines the inside of the intestine during pregnancy and lactation.”
#ReproSky 🧪
www.nature.com/articles/d41...

I would be interested. Please add me.

A panoramic view of cell population dynamics in mammalian aging To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...

Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!

I would love to join!

I would love to be included - thank you.

A prenatal skin atlas reveals immune regulation of human skin morphogenesis Nature - A comprehensive multi-omics reference atlas of prenatal human skin shows that innate immune cells crosstalk with non-immune cells to perform pivotal roles in skin morphogenesis, including...

Exciting to see the collection of HCA papers out this week in Nature. Honored to be in the mix with our collaboration with @mhaniffa.bsky.social and Sarah Teichmann on a fetal skin atlas. Bravo to Hudaa, Elena, and Bayanne et al, for pulling this study together. A tremendous effort! rdcu.be/d02Yx