Christian Baumann

Fwd: Fwd: “I hope this email finds you well”

This comic is becoming increasingly realistic.
m.xkcd.com/3056/

I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪

Extensive lateral gene transfer between proto‐eukaryotes and Heimdallarchaeia suggests their close association during eukaryogenesis It has been proposed by Ettema and colleagues, in the two-domain framework for the tree of life, that Eukarya emerged from Heimdallarchaeia, as sister group to Hodarchaeales. Looking at the individua....

Are Asgard archaea the ancestors of eukaryotes? Likely not. Very insightful paper by @pforterrr.bsky.social

Getting closer to the year 3000

Did you know your MacBook has a sensor that knows the exact angle of the screen hinge?

It’s not exposed as a public API, but I figured out a way to read it and make it sound like an old wooden door.

Source code and a downloadable app to try it yourself […]

[Original post on hachyderm.io]

OPRLM: A Web Tool and a Database for Positioning and Simulations of Proteins in Realistic Lipid Membranes Molecular dynamics (MD) simulations in explicit lipid bilayers enable modeling of protein-lipid interactions essential for membrane protein functions …

Sounds very neat:

OPRLM: A Web Tool and a Database for Positioning and Simulations of Proteins in Realistic Lipid Membranes - ScienceDirect share.google/yPJkioKNph4m...

Happy to share the latest work from the lab, led by @mudgal17.bsky.social‬, in collaboration with the Weis lab @ethzurich.bsky.social.
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)

The peer review process is a flawless system that has no issues whatsoever /s

Fresh off the press from the @lek-lab.bsky.social: Modulation of histone tail electrostatic potentials in nucleosome core particles by acetylation and PARylation
#NMRchat
www.pnas.org/doi/10.1073/...

Made an attempt at generating a video of protein unfolding with #veo3 😹

The Vatican now takes a stronger stand for science than the US government:
www.nature.com/articles/d41...

www.pas.va/en/events/20...

Complexity myths and the misappropriation of evolutionary theory | PNAS Recent papers by physicists, chemists, and geologists lay claim to the discovery of new principles of evolution that have somehow eluded over a cen...

Complexity myths and the misappropriation of evolutionary theory

www.pnas.org/doi/10.1073/...

David R. Hagen just solved a small mystery that I mentioned 13 years ago in the mouseover text of a comic drhagen.com/blog/the-mis...

Membranes are functionalized by a proteolipid code - BMC Biology Membranes are protein and lipid structures that surround cells and other biological compartments. We present a conceptual model wherein all membranes are organized into structural and functional zones...

#lipidtime The proteolipid code is the ultimate membrane model. It accommodates all observations while also being a falsifiable scientific theory that rejects the status quo (lipid rafts, picket fences, etc.)
doi.org/10.1186/s129...
Please read it.

I wasn’t aware of this. The concept sounds really cool. I like how it gives proteins a more active role in membrane formation. I’ll have to take a closer look with a fresh mind.

For everyone interested in how membrane thickness differs between and within organelles, by @deglushk.bsky.social, S. Böhm & M. Beck: www.biorxiv.org/content/10.1...

The side of a box of Parafilm that features the flask, dish, and beaker. Text has been added under them. The flask is labelled chemistry, the dish biology, and the beaker jam making. Jam making is written in a different handwritten font

At times like these it's important to remember the 3 branches of science

It’s Mary Anning’s birthday, so time to share @katebeaton.bsky.social’s brilliant cartoon again.

Huge congrats to the authors for pulling this off:

Activation dynamics traced through a G protein–coupled receptor by 81 1H-15N NMR probes | Science www.science.org/doi/full/10....

After years, I finally read this great paper on what the success of trial-and-error methods and AI tells us about emergent properties and reductionism in bio sciences: rdcu.be/emtBS

‘About as close to aliens as we’ll ever get.’ Can AI crack animal language? Dolittle Prize recognizes breakthroughs in translating “speech” of dolphins, cuttlefish, and other creatures

"Dolphins call each other’s signature whistles if they get separated. Once, we played one of those whistles while the pair was still together. They responded with a totally different whistle. We call it the 'WTF whistle,' because it really did seem like that’s what they were asking." @science.org

...and big thanks to @jiwasa.bsky.social for making this amazing video to illustrate the strand-sliding mechanism!

Why are biological membranes asymmetric, with different lipids in the two bilayer leaflets? Discovered in the 70s, lipid asymmetry is linked to many cellular processes, but why the cell needs it is largely unclear. @pavelbarahtjan.bsky.social addresses this question: www.biorxiv.org/content/10.1...

New paper out!
We discovered a tiny archaeon with the smallest known archaeal genome — only 238 kbp!
Candidatus Sukunaarchaeum mirabile has almost no recognizable metabolic pathways and may rely heavily on a host to survive.
It also represents a novel, deep-branching lineage in the archaeal tree.

This is figure 1, which shows the movement patterns for sea lion Ronan and human subject 08 to a 120 bpm metronome.

A study in Scientific Reports finds that a Californian sea lion trained to move in time with a metronome can keep a beat better than some humans. go.nature.com/4lY7mlU 🧪

Learning millisecond protein dynamics from what is missing in NMR spectra Many proteins’ biological functions rely on interconversions between multiple conformations occurring at micro-to millisecond (µs-ms) timescales. A lack of standardized, large-scale experimental data ...

Next Tues (4/29) at **4:30PM** ET, we will have @ginaelnesr.bsky.social @hkws.bsky.social present "Learning millisecond protein dynamics from what is missing in NMR spectra"

Paper: biorxiv.org/content/10.1...

Sign up on our website for zoom links!

Super weird debris covered thing ‘walking’ on a diatom from the charles river, with another diatom attached to it, along for the ride. For the life of me could not make out what it was. #sciart #microscopy #plankton

Those trying to understand the tariffs as economic policy are dangerously naive.

No, the tariffs are a tool to collapse our democracy. A means to compel loyalty from every business that will need to petition Trump for relief.

1/ A 🧵 to explain his plan and how we fight back.

Video of the international student at Tufts being arrested by "federal authorities" in Massachusetts has been released and it's terrifying.

They're not even uniformed officers. Just secret police thugs in hoodies and masks.

From WCVB: youtu.be/PuFIs7OkzYY