Amélie Freal

They are lucky to have you as an instructor (and to work on such a cool topic!) Have fun!!!

Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!

Well done 🎊🎉!!

@marijnkuijpers.bsky.social maybe?

Congratulations!!

Latest from @mattrasband.bsky.social, as seen in Chile presented by @vicpal.bsky.social: planar cell polarity protein SCRIB is located along the periodic scaffold of the axon initial segment, where it connects ankyrin G to the Kv1/PSD93/LGI1/ADAM22 complex www.science.org/doi/10.1126/...

Congrats Martijn!!

Well done!!!

Job alert 🚨 We are hiring a research assistant!

This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.

Please spread the word!

New engineer position open at the Paris Brain institute to perform #electrophysiology (patch-clamp, LFP, MEA...) on various in vitro models (cell lines, primary cultures, brain slices and organoids) at the ePHYS core facility.
Check it out!
offres.institutducerveau-icm.org/fr/jobs/1934...

Axon Initial Segment Structure and Function in Health and Disease | Physiological Reviews At the simplest level, neurons are structured to integrate synaptic input and perform computational transforms on that input, converting it into an action potential (AP) code. This process-converting synaptic input into AP output-typically occurs in a specialized region of axon termed the axon initial segment (AIS). The AIS, as its name implies, is often contained to the first section of axon abutted to the soma and is home to a dizzying array of ion channels, attendant scaffolding proteins, intracellular organelles, extracellular proteins, and, in some cases, synapses. The AIS serves multiple roles as the final arbiter for determining if inputs are sufficient to evoke APs, as a gatekeeper that physically separates the somatodendritic domain from the axon proper, and as a regulator of overall neuronal excitability, dynamically tuning its size to best suit the needs of parent neurons. These complex roles have received considerable attention from experimentalists and theoreticians alike. Here, we review recent advances in our understanding of the AIS and its role in neuronal integration and polarity in health and disease.

@pjenkinslab.bsky.social and I wrote a review on the axon initial segment. We tried our best to discuss the state of the field and provide our perspective (and resolution for) some current sticking points. Hope it's useful!

doi.org/10.1152/phys...

Another week another #VTiSIM Install.... this time @vuamsterdam.bsky.social. Thanks to our partners #Evident and #Hamamatsu.... Happy Imaging 😊🦠🔬

and we are very much excited to get started with imaging!!! 😀

Here are the links:
PhD position: lnkd.in/e8wNeTrm
Post-doc position: lnkd.in/eRY4MEQR

And if you have questions, please reach out!

We are recruiting!!
If you are looking for a post-doc (ephys, slice imaging) or a PhD position (molecular neuroscience), are interested in Axon Initial Segment plasticity and want to join a nice team in a great environment, have a look!
And, that's us 👇

with or without cornichons?

📣 Postdoc opportunity !
Our lab is hiring a funded postdoc to explore the development of fear circuits using slice electrophysiology. If you have expertise in this area and are interested about cutting-edge neuroscience, reach out ! 🤗
klinglerlab.org
Please share with your network 🙏

Our newest paper on the fascinating biology DRG neurons.
@eLife: Axon-specific microtubule regulation drives asymmetric regeneration of sensory neuron axons doi.org/10.7554/eLif...
Tour de force by Catarina Costa @i3suporto.bsky.social et al

Dynamic regulation of cortical interneuron wiring Inhibitory interneurons play crucial roles in modulating the circuits and activity patterns of the cerebral cortex. In particular, interneurons must a…

Our little update on the latest knowledge on interneuron wiring! www.sciencedirect.com/science/arti...

A superb review with the latest insights on the Axon Initial Segment from @ameliefreal.bsky.social & Casper Hoogenraad, was a joy reading this 😀

already a must read. The latest about the #axoninitialsegment !

Thanks feline!

congratulations!!

It is already spinning off 😂

It was not easy to draw a full picture (sincere apologies if your work is not included), but it is exciting to see how much our field grew and progressed in the last decade; exciting times ahead for AIS aficionados and neuronal cell biologists!

Everything you always wanted to know about the Axon Initial Segment might be here: authors.elsevier.com/sd/article/S...

But what if you only carefully quickly check right in the middle of the slide?
Fingers crossed for your staining!

Congratulations to you and the team!! Glad to see it out!

Great to see it out! Congrats Hanieh & team, well done it’s a really cool story!(#makeNeuronalCellBioGreatAgain!)