Mike Goodwin

Advances in Fragmentation Techniques for Glycomics and Glycoproteomics Glycosylation, the enzymatic addition of carbohydrate moieties to proteins, is essential for immune recognition, protein folding, and disease progression. The structural complexity of glycans and the...

analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...

Simulation Study of a Novel Cylindrical Direct Current‐Ion Funnel to Improve Ion Transmission Rationale Proton transfer reaction mass spectrometry (PTR-MS) is a widely used technique for on-line detection of volatile organic compounds (VOCs). Sensitivity enhancement is an important developme.....

analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...

Evaluation of a Prototype Orbitrap Astral Zoom Mass Spectrometer for Quantitative Proteomics─Beyond Identification Lists Mass spectrometry instrumentation continues to evolve rapidly, yet quantifying these advances beyond conventional peptide and protein detections remains challenging. Here, we evaluate a modified Orbit...

pubs.acs.org/doi/10.1021/...

Space Charge Induced Dissociation Due to Extended Ion Accumulation Preceding Cyclic Ion Mobility Separation Cyclic ion mobility spectrometry (cIMS) provides the potential for high resolution separations of small molecule isomers using multiple passes in a closed-loop geometry. Achieving this potential, howe...

pubs.acs.org/doi/10.1021/...

AlphaDIA enables DIA transfer learning for feature-free proteomics - Nature Biotechnology An open-source platform for data-independent acquisition proteomics adapts predicted libraries to experimental settings.

www.nature.com/articles/s41...

High Dynamic Range Peptide Mass Spectrometry Using Segmented Precursor Ion Accumulation Limited sensitivity and depth of proteome sampling in experiments using data-dependent acquisition (DDA) mass spectrometry are usually attributed to an insufficient rate of fragmentation spectra acquisition relative to the number of coeluting potential targets. Here, we demonstrated that limited sensitivity and dynamic range of MS1 scans reduce detection of low-intensity ions and thus their selection for fragmentation. As abundant ions occupy a large fraction of the ion accumulation capacity, we sought to improve MS1 detection of rare analytes by an easily implementable strategy based on gas-phase segmentation of the MS1 scan range, followed by coaccumulation and detection of all ions. The quadrupolar isolation windows used to segment the MS1 scan range are designed to transmit, on average, an equal number of charges, consistent with the parameter used by many recent mass spectrometers to regulate ion trap filling. This strategy, which we named high dynamic range MS1 (HDR-MS1), reduces the contribution of abundant ions to reaching the maximum ion capacity. As a result, HDR MS1 showed improved dynamic range and sensitivity compared to conventional full-range scans, resulting in a higher number of peptides and protein identifications under identical MS2 parameters, less redundant precursor ion sampling, and a higher rate of quantified precursor ions. HDR MS1 scans are compatible with any DDA precursor selection filter and MS2 parameter, and the generated files can be analyzed using any software for peptide-spectral matching and quantification.

Isn't this the same idea as "boxcar"?

High Dynamic Range Peptide Mass Spectrometry Using Segmented Precursor Ion Accumulation | Analytical Chemistry pubs.acs.org/doi/10.1021/...

The UHMR has had Orbitrap-based CDMS for several years now.

Transmitting and Filtering Ions in the Open Air by Applying Spirally Rotating Electric Fields to a Flexible and Segmented Stacked Ring Ion Guide There are many potential advantages to performing ion manipulations at atmospheric pressure (AP) compared to in vacuum. However, the RF electric fields commonly employed in vacuum-based systems are mo...

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Improving the Quadrupole to Ion Mobility Region in a Digital Quadrupole/Ion Mobility/Orbitrap Mass Spectrometer A quadrupole/drift tube ion mobility/Orbitrap instrument requires pumping from atmosphere to 10–5 Torr in the quadrupole analyzer region, back to 1 Torr for the drift tube, and a return to 10–5 Torr f...

dx.doi.org/10.1021/jasm...

Segmented-Field-Gradient-Focusing Ion Guide for Simultaneously Improved Ion Transfer across a Wide Mass Range and Enhanced Sensitivity The sensitivity of the atmospheric pressure ionization mass spectrometer (API-MS) has been improved owing to the advancement in the atmospheric pressure interface. However, ion scattering losses in th...

pubs.acs.org/doi/10.1021/...

SLIMPHONY: A SLIM-Based Instrument That Orchestrates Complex Ion Mobility–Mass Spectrometry Experiments The inherent heterogeneity of biological macromolecules offers a unique challenge for analysis. The combination of ion mobility (IM) and mass spectrometry (MS) is sensitive to the size, shape, and dyn...

pubs.acs.org/doi/pdf/10.1...

No details from me.

I believe the term "electrophoretic mobility" is common in the field. I heard CE being likened to "liquid phase ion mobility" many times in my work at 908 Devices. However, it feels a bit strange to be dropped in a paper's title like this.

Real-Time Instrument Control across Multiple Orbitrap Platforms through a Single Software Interface Applications using real-time spectral analysis and real-time instrument control have emerged in recent years as powerful tools to improve the capabilities and sensitivity of mass spectrometers. Softwa...

pubs.acs.org/doi/10.1021/...

Improving Proteomic Dynamic Range with Multiple Accumulation Precursor Mass Spectrometry Orbitrap (OT)-based mass spectrometer platforms are a gold standard in high-resolution mass spectrometry, where their primary disadvantage is slower-scanning speed in comparison to time-of-flight or l...

pubs.acs.org/doi/10.1021/...

They showed this at asms years ago.

Enhanced Charge-Sensitive Amplifier Performance Leads to Substantially Reduced CD-MS Measurement Times for Charge State Resolution In charge detection mass spectrometry (CD-MS) ions are trapped in an electrostatic linear ion trap (ELIT) where they oscillate back and forth through a conducting cylinder. The oscillating ions induce...

pubs.acs.org/doi/10.1021/...

Comparison of the results of the aberration approach for the calculation of electrostatic TOF mass analyzers with simulation in SIMION In the last few years, high-resolution time-of-flight mass analyzers (TOF-MA) have been intensively developed. Their development requires tools that p…

www.sciencedirect.com/science/arti...

Manipulation of Electrospray-Produced Protein and Peptide Ions with Acoustic Fields at Atmospheric Pressure The coupling of electrospray ionization (ESI) with the newly discovered acoustic ion manipulation (AIM) phenomenon is demonstrated for biopolymer analytes, including peptides, proteins, and DNA. It is...

chemrxiv.org/engage/chemr...

Nice. What made the difference?

Particularly tricky m/z?

Two-Dimensional Tandem Mass Spectrometry in a Linear Quadrupole Ion Trap Using Consecutive Product Ion Sweeps Two-dimensional tandem mass spectrometry (2D-MS/MS) is a powerful analysis technique which can quickly produce a map of all precursor-product ion rela…

www.sciencedirect.com/science/arti...

The point differential in Bill Belichick's first game at UNC might end up larger than the age differential in his relationship, which is saying something. #belichick

Seems like many groups are realizing the inefficiencies of traditional TOF designs and working on one of the issues (m/z dispersion when sending ions out of an rf trapping device into a pusher).

Next Generation MasSpec Pen Technology: Innovations in Instrumentation and Medical Device Development for Intraoperative Use Publication date: Available online 26 August 2025 Source: International Journal of Mass Spectrometry Author(s): Charles A. Wolfe, Sydney Povilaitis, Michael F. Keating, Ashley E. Montgomery, Bryan M. Burt, Amir A. Jazaeri, Livia S. Eberlin

(IJMS) Next Generation MasSpec Pen Technology: Innovations in Instrumentation and Medical Device Development for Intraoperative Use: Publication date: Available online 26 August 2025

Source: International Journal of Mass Spectrometry

Author(s): Charles A. Wolfe, Sydney… #ijms #MassSpecRSS

You can dm me.

Demonstration of a Nested Electrostatic Linear Ion Trap for Flexibility in Selecting Analyzer Figures-of-Merit An electrostatic linear ion trap (ELIT) is used to trap ions between two ion mirrors with image current detection by central detection electrode. Tran…

www.sciencedirect.com/science/arti...

Simulation and Development of an Ion Funnel for Miniature Mass Spectrometers Rationale Miniature mass spectrometers are increasingly used in portable and on-site analysis due to their compact size and light weight. However, miniaturization, higher operating gas pressure, and...

analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...