Nirav Patel

Spatial gene expression map in a colorectal tumour sample (Source: Yurike Laurensia, Li Bo, and Grace Yeo, Prabhakar Lab, A*STAR’s GIS)

@astar-gis.bsky.social teams up with 10x Genomics to revolutionize drug discovery for #TISHUMAP! Using AI & spatial biology, this project will analyze thousands of tissue samples to fast-track drug target discovery in cancer & inflammatory diseases. A major step toward precision medicine!
#Genomics

Congratulations Sini!

From boxes to brilliance at #AACR25 in the Windy City! 🚀 Demos, data, and expert talks await! Whether starting your spatial experiment or refining your single cell pipeline, we’re here to help! Visit Booth #2456 and make it your home base: pages.10xgenomics.com/rs/446-PBO-7...

HHS starts layoffs of thousands of workers across its agencies Layoff notices began arriving early Tuesday for thousands of employees of HHS and its subsidiary agencies, with as many 10,000 workers potentially expected to be hit by the cuts.

How I will remember April Fools' Day 2025.
Reckless.
My heart is out for these dedicated folks at NIH, FDA and CDC
www.statnews.com/2025/04/01/h...

Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...

Xenium product updates : RNA and protein multiomics workflow @10xgenomics.bsky.social #AGBT2025 #AGBT25

Help us raise the roof at our afterparty happening in Kice and Lanai suite 191, starting at 9:30 PM. There’s no better way to end the day than with some sips and snacks, so drop on by!

10x is all about biological breakthroughs, and we're just getting started. If you missed our AGBT livestream, don't worry. Stay tuned for a link to the recording to learn the latest about Xenium and how it enables protein and RNA with a single workflow on a single slide.

the yield on NIH research for economic activity

How to get 146% return on investment?
The NIH. That's just the economic benefit.
Biomedical research promotes human health.

Yes

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

Every cell has a story to tell—if only they had a megaphone (or just high-quality molecular profiling). Standardized, scalable data is the key, and the Billion Cells Project is making sure no cell goes unheard!

@10xgenomics.bsky.social

#singlecell #insights #AI #foundationmodels #1billion

WOW!! 🤩 Congrats to Banovich et al. on the LARGEST imaging-based spatial transcriptomic study of the human lung to date! This study discovers conserved spatial pathological signatures and alveolar remodeling in pulmonary fibrosis disease progression.

Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis - Nature Genetics Xenium spatial transcriptomic profiling of pulmonary fibrosis characterizes cell composition dynamics and histopathological features associated with the disease.

Excited to post my first #skySplain about our recent work published yesterday in Nature Genetics! www.nature.com/articles/s41.... One of the first authors of this study - Annika Vannan – actually wrote this breakdown, but she's not yet over here on bluesky and asked me to post!

Hey, that's us! Learn more about this massive Alzheimer's disease study by us and our collaborators: alleninstitute.org/news/landmar...

Read the @natureneuro.bsky.social article: www.nature.com/articles/s41...

🧠📈

Sign up for the 10x Genomics pre-show event at AGBT, “Revving Up Insights in Single Cell and Spatial Exploration.” You’ll get a first look at our 2025 Roadmap and learn about our latest and greatest technology. Register now: bit.ly/3Wg6qxY

I don’t have a definition. My curiosity was mostly driven by your comment there..

How do you define frothiness in these names? Curious to hear your thoughts..

Comparative transcriptomic analyses of thymocytes using 10x Genomics and Parse scRNA-seq technologies - BMC Genomics Background Single-cell RNA sequencing experiments commonly use 10x Genomics (10x) kits due to their high-throughput capacity and standardized protocols. Recently, Parse Biosciences (Parse) introduced ...

Publication benchmarking @10xgenomics.bsky.social single cell versus #Parse on Mouse thymocytes. 10X Genomics data more predictable, consistent and sensitive: e.g. Cd3d, Cd3g genes not found in Parse thymocyte data. Batch effects and doublets for Parse. bmcgenomics.biomedcentral.com/articles/10....

A comprehensive analysis framework for evaluating commercial single-cell RNA sequencing technologies Abstract. This study examined nine prominent commercially available single-cell RNA sequencing (scRNA-seq) kits across four technology groups. Each kit was

Analyzed 9 #scRNAseq kits using PBMCs from 1 donor. Chromium Fixed RNA Profiling by 10x Genomics excelled in performance. Study offers insights on cost and duration. #Biotech #Research PMID:39675380, Nucleic Acids Res 2024, @NAR_Open doi.org/10.1093/nar/...

10X Genomics will release a poly-A version of Visium HD with CytAssist, opening up a high resolution biopsy version of the Chromium GEM-X.

Forecast of US life expectancy to 2050 vs >200 countries
—"alarming trajectory of health challenges in the USA"
—need to invest in "scientific innovation, health-care access, preventive health care, risk exposure reduction, and education."
www.thelancet.com/journals/lan...