Christina Ramelow

A checklist for designing and improving the visualization of scientific data Nature Cell Biology - Creating clear and engaging scientific figures is crucial to communicate complex data. In this Comment, I condense principles from design, visual perception and data...

I gave in! After students asking for it, I now made a simple figure design checklist.
To help all scientists w/o graphic skills create clear, accessible, and truthful charts!
-> Out in @nature Cell Biology: rdcu.be/erwl4

#DataVisualization #PhD #SciComm

Thx for review @bethcimini.bsky.social + 2

Announcing the 2024 NPR College Podcast Challenge Honorable Mentions Here are some of the best entries in NPR's 2024 College Podcast Challenge.

Here are some of the best entries in NPR's 2024 College Podcast Challenge.

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative diseases. This study reveals that the interferon-induced immunoproteasome drastically decreases proteasomal ac...

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: @cellpress.bsky.social www.cell.com/cell/fulltex...

Peripheral infection wires T cells in the brain
www.nature.com/articles/s41...

CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells - Nature The transcription factor CREM is a pivotal regulator of NK cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies based on this cell population and chimeri...

I’m thrilled to share our work out now in Nature identifying CREM as a central intracellular checkpoin in #CARNK cells.

📄Link: nature.com/articles/s41...

Our story👇🏼

On-demand microglia deliver the therapeutic payload in Alzheimer’s disease In this issue, Chadarevian et al. showed that engraftment of human iPSC-derived microglia (iMG) engineered to express secreted neprilysin (sNEP) under the plaque-responsive CD9 promoter reduces amyloi...

On-demand microglia deliver the therapeutic payload in Alzheimer’s disease @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...

🚀 Excited to release BoltzDesign1!

✨ Now with LogMD-based trajectory visualization.
🔗 Demo: rcsb.ai/ff9c2b1ee8
Feedback & collabs welcome! 🙌

🔗: GitHub: github.com/yehlincho/Bo...
🔗: Colab: colab.research.google.com/github/yehli...
@sokrypton.org @martinpacesa.bsky.social

Genome Medicine

A study published in Genome Medicine provides a framework to support the integration of a single untargeted proteomics test into routine diagnostic practice for the diagnosis of mitochondrial and potentially other rare genetic disorders.
bit.ly/4dKQ48e

#Epigenetics #MedSky

Distinct type I and II interferon responses direct cortical and medullary thymic epithelial cell development Single-cell transcriptomics identifies type I and II interferons as regulators of cortical and medullary thymic epithelial differentiation.

In #Science #Immunology, researchers at @stanfordmedicine.bsky.social studied #IFNs in human #fetal #thymus development. They found type I & II IFNs play distinct but critical roles in cortical & medullary thymic #EpithelialCell differentiation!

Four pins from Two Photon Art. One is a brain cloud with crystals dangling off, another is a brown hand holding a test tube with flowers that says “keep growing”, another is a pride color rainbow brain, and the other is a saggital section of a brain.

These beautiful pins came in! 🙌🏾 they’re gifts for our MINDS post-bacc scholars who will be starting grad school in the fall ❤️🎉

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Always love supporting women-owned, people-of-color-owned businesses ✨ but I especially love supporting my friends @christineliu.art 😍 twophotonart.com

Interferon-γ orchestrates leptomeningeal anti-tumour response - Nature Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the leptomening...

I am pleased to share our recent publication, fruit of a wonderful collaboration with truly amazing colleagues @adrienneboire.bsky.social and @meningojan.bsky.social, whose work was a tour de force demonstrating that immunology in the brain is a different beast -> www.nature.com/articles/s41...

Today in @nature.com , we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specification of human cortical layers and areas.
We built an interactive browser to explore the spatial data: walshlab.org/research/cor...
Paper link below 👇

JCI - The gut microbiome controls reactive astrocytosis during Aβ amyloidosis via propionate-mediated regulation of IL-17 www.jci.org/articles/vie...

Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses T helper (Th) 2 cells and group 2 innate lymphoid cells (ILC2s) express similar effector molecules in response to distinct signals—TCR engagement and interleukin-33, respectively. Guichard et al. find that NF-κB is essential for type 2 cytokine production in ILC2s but dispensable in Th2 cells, with pre-existing chromatin accessibility dictating NF-κB recruitment and shaping cell-type-specific transcriptional programs.

Online now: Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses

#GliaPapers #GliaMay2025
MAY COVER
Carl Weigert, Mihály (von) Lenhossék, Gustav Retzius, and Hans Held surround hand drawn images of glia from the late 1800 and early 1900s. (see Kettenmann et al, onlinelibrary.wiley.com/doi/10.1002/...)

High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits - Nature Biotechnology T cell-specific antigens are discovered at high throughput without killing target cells.

T cell-specific antigens are discovered at high throughput without killing target cells go.nature.com/3L6cuDp
rdcu.be/ekKtU

Redefining CNS immune privilege - Nature Reviews Immunology In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...

Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.

@jonykipnis.bsky.social
www.nature.com/articles/s41...

Confocal micrograph

My mom used to love #FluorescenceFriday, so I will keep posting in her memory ❤️

This photo shows neurons in the hippocampus accumulating phospho-tau in our monkey model of Alzheimer's Disease.

Markers: Dapi 🔵, Neun 🔴, pTau 422🟣, AT8🟡

Together with leading science organizations, ASM filed an amicus brief calling for immediate restoration of NIH grants supporting early-career scientists. Read the press release: asm.org/press-releas...

Register - IMMUNOLOGY2025™ Join or renew your AAI membership for 2025 to immediately be eligible for discounted IMMUNOLOGY2025™ registration fees.

I’m excited to be speaking at #IMMUNOLOGY2025™ on May 7 during the Lymphatic Immunophysiology Major Symposium! Join us to discuss the meningeal lymphatic system and its impact on brain immunity and function. #immunology #neuroimmunology
Register today! immunology2025.aai.org/register/ #AAI2025

Inflammasome signaling in astrocytes modulates hippocampal plasticity The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in memory...

Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. @cp-immunity.bsky.social
All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...

It was so great for my lab to be able to contribute to this awesome study led by @fchrisbennett.bsky.social @nachoriko.bsky.social @waisenberg.bsky.social.

Check out this paper from the Movahedi lab! It’s a great companion to ours - showing the populations of brain macrophages that monocytes can replace.

Congrats to first author Jonathan Bastos!

Next Generation Leaders The Next Generation Leaders program at the Allen Institute aims to support emerging and diverse early-career researchers in bioscience who will contribute to cultivating new ideas to make a broad, tra...

Open call for Next Generation Leaders!

Our NGL program recognizes early career scientists with fresh and innovative perspectives. For 3 years, NGLs contribute to ongoing research and initiatives at the Allen Institute.

Apply by June 3. alleninstitute.org/about/people...

Trump’s Astonishing 100 Days, in 8 Charts (Gift Article) By many measures, the opening months of President Trump’s second term stand apart from those of essentially any modern president.

New NYT Article on the first 100 days in Charts

www.nytimes.com/interactive/...

Deeply concerning in many regards...

Sadly (although it is good for folks to understand), NIH funding slowdown made the cut...

1/2

Mammalian cells eliminate nascent chains stalled during co-translational protein translocation by activating a ribosome UFMylation-dependent TAQC process at the ER. Ennis, Wang, Ye et al. establish a role for NEMF-mediated CAT tailing in TAQC. rupress.org/jcb/article/...
#ER_literature

Our latest work now online in Cell:

Rewriting regulatory DNA to dissect and reprogram gene expression

Our new method (Variant-EFFECTS) uses high-throughput prime editing + flow sorting + sequencing to precisely measure effects of noncoding variants on gene expression

Thread 👇

Real time characterization of the MAPK pathway using native mass spectrometry - Communications Biology Native mass spectrometry enables real time characterization of MAPK phosphorylation cascade and impact of oncogenic RAS mutants on kinetics.

Native mass spectrometry enables real time characterization of MAPK phosphorylation cascade and impact of oncogenic RAS mutants on kinetics.

doi.org/10.1038/s420...

University websites updated to reflect commitments to diversity, non-discrimination Many University websites, including those affiliated with admissions, academic departments, and diversity, equity, and inclusion (DEI) initiatives, have been updated to reflect Princeton’s ongoing com...

At Princeton University we are being clear about our continued commitment to diversity and nondiscrimination, in full compliance with law (as opposed to executive order) and consistent with our ethical responsibilities as educators for the entire nation. www.dailyprincetonian.com/article/2025...

Events

Explore top neuroscience meetings and events. Filter events by topic, and see upcoming webinars compiled by @worldwideneuro.bsky.social.

Are you organizing a neuroscience conference? Share it with us at community@thetransmitter.org

#neuroskyence

www.thetransmitter.org/events/?utm_...