Nathan Salomonis

Splicing regulatory dynamics for precision analysis and treatment of heterogeneous leukemias Broad dysregulated splicing in AML partially phenocopies splicing factor mutations, is prognostic, and can be pharmacologically reversed.

New in STM, check out our integrative bulk & single-cell long-read analysis to discover and test new therapies in leukemia. We developed OncoSplice, to define new splicing defined subtypes and predict regulators. PRMT5 inhibition partially rescued mis-splicing & inhibited leukemic growth. More soon!

our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell!

key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity

many are "negative regulators" & misexpressed in cancer

www.sciencedirect.com/science/arti...

This means that the work stemming out of the use of this models can be used without licensing issues, including for commercial use.

NiCo identifies extrinsic drivers of cell state modulation by niche covariation analysis - Nature Communications A key question in single-cell biology is how cells communicate and exchange information with neighboring cells in tissues. Here, the authors introduce NiCo to predict the downstream effect of cell-cel...

New algorithm for spatial transcriptome analysis that predicts the crosstalk of cell types co-localized in tissue niches. Also studies the downstream effects of cell-cell interactions by inferring covarying gene programs.

doi.org/10.1038/s414...

#spatial #transcriptomics #scrnaseq #NMF

Tabula Sapiens reveals transcription factor expression, senescence effects, and sex-specific features in cell types from 28 human organs and tissues The Tabula Sapiens is a reference human cell atlas containing single cell transcriptomic data from more than two dozen organs and tissues. Here we report Tabula Sapiens 2.0 which includes data from ni...

Major milestone: Tabula Sapiens 2.0 maps tissue composition & TF expression in 175 cell types, identifying 745 ubiquitous & 890 cell type-specific TFs (many still uncharacterized -> #Codebook) w/ roles in tissue homeostasis, stress response & metabolism. #SingleCell www.biorxiv.org/content/10.1...

An integrated transcriptomic cell atlas of human neural organoids - Nature A human neural organoid cell atlas integrating 36 single-cell transcriptomic datasets shows cell types and states and estimates transcriptomic similarity between primary and organoid counterparts, sho...

Super excited to share our Human Neural Organoid Atlas, now out in Nature! Led by @zhisonghe.bsky.social @josch1.bsky.social, and myself, this resource was created from 36 scRNA-seq datasets—totalling over 1.7 million cells! 🔬✨
 www.nature.com/articles/s41...


Find out how it can serve you ⏬

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I’ll check with the study coordinator. I don’t see the Molecular Datasets and Sample Manifest live at www.ncbi.nlm.nih.gov/projects/gap...