Katherine King MD PhD

Yahoo! I was the only girl in some of my classes in high school and college. Though we’ve come a long way, women are still a minority in science. Excited to see the blossoming careers of many young women in science today!

Want to understand complex intrinsic and extrinsic metabolic regulation of HSCs? Our latest @natcellbio.nature.com review, led by @aysegulerdemm.bsky.social, synthesize insights into cell fate decisions and highlight implications for leukemogenesis. @nickvangastel.bsky.social
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Happy to share our latest work on the epigenetic basis of trained immunity in hematopoietic stem cells! @bcmhouston.bsky.social @texaschildrens.bsky.social

Thanks @insight.jci.org for highlighting our new work to investigate the epigenetic basis of central trained immunity. Hematopoietic stem cells carry many secrets! In this case memories that are transmitted to innate immune cells. Congrats to fabulous student Brandon Tran on this publication!

Cool paper from @welner.bsky.social and Ferrell labs!

TODAY at #ASH2025 New Frontiers in Neutrophil Biology. W311 at 4pm. Ostuni, Bonnet, Findlay. See you there!! @welner.bsky.social @leegrimeslab.bsky.social

Caroline Sands @bcm-mstp.bsky.social and I met up at #ASH2025. So fun 😍

What an awesome stem cell session speaker group for #ASH25 Workshop on Myeloid Development @vangalenlab.bsky.social @thekinglab.bsky.social @paralkarlab.bsky.social Sandra Pinho and Allison Yeh (love the photobomb!)

ASH or bust! #ash2025

ASH is coming! Excited to present alongside Vikram Paralkar, Sandra Pinho, Peter Van Galen, and Alison Yeh at the stem cell session of the myeloid workshop on Friday. @ericpietras.bsky.social will be moderating— don’t miss it!

Wow! My student Arushana Maknojia was awarded the Deborah K. Martin Award for best graduate student at BCM! So proud!

Lab Halloween 2025 is in the books— can you guess our theme?

For my lab lead friends, check out this article of best practices from my colleagues and I on the ISEH Junior PI committee on organizing a leading your team. authors.elsevier.com/c/1lxZ~,6sio...

Jak stat jak stat fun to have @mpndoc.bsky.social in town for a seminar! Thanks for inflammatory insights and inspiration to cure patients!

Congrats to Nicole Wang and Jennifer Deger on their beautiful thesis defenses today in the MSTP October double header! So proud of you both! @bcmfromthelabs.bsky.social

Negative Selection! For those who know.

Great science, food, and hospitality at #ISEH2025 Kumamoto. Several new collaborations planned!

I am so grateful to be able to spend time with colleagues at #iseh2025. Fantastic science and community.

@rcao1001.bsky.social @bcmfromthelabs.bsky.social @texaschildrens.bsky.social

Hematopoietic stem and progenitor cells as a reservoir for trained immunity Inflammation supports selection, differentiation bias, and epigenetic reprogramming of hematopoietic stem and progenitor cells to generate innate immune memory.

Central trained immunity is still a nascent field— is there true reprogramming of hematopoietic progenitors to influence innate immunity, or is this selection for lineage biased cells? We explore the nuances in this new review. doi.org/10.7554/eLif... awesome collab with Eva Kaufmann and team!

Less than a month until ISEH @isehsociety.bsky.social annual meeting in Kumamoto! Bringing some new science to share and excited to see friends and try the food!

It’s just a noncompeting renewal, but I’ve never been so happy.

Thank you @keisukeito-lab.bsky.social ! 😍

Aw thanks so much Adam! Let’s talk more about how these mutations affect migration of immune cells across tissues.

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A huge thanks to our collaborative team for contributing to this story @eirinipapapetrou.bsky.social Michael Rauh, Samuele Marro, Sidd Jaiswal, @goodell-lab.bsky.social, @micrornax.bsky.social and so many more.

Lots of interesting pieces here including how immune cells get into the brain and how often they replace microglia.

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Human data corroborates a protective effect of TET2 CH against AD

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This is interesting since Dnmt3a and Tet2 are often lumped together but actually have opposite enzymatic functions.

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Amazingly, Tet2-mutant marrow protected against AD, whereas Dnmt3a-mutant marrow had no effect.

We transplanted 5xFAD mice (a model for AD) with Dnmt3a or Tet2 mutant marrow, the two most common mutations found in age-associated CH

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We’re interested in infection as a driver of clonal hematopoiesis, and, conversely, how CH affects immune function.