Chenshu Liu

Congrats Soni and team!

Congratulations Amit!

Congratulations Sam!!!

Bhalla Lab - Research Specialist (Junior Specialist) University of California, Santa Cruz is hiring. Apply now!

Hi all, I'm hiring a junior specialist/research technician for my lab at UCSC. An ideal applicant would be an undergraduate who would like more research experience before applying for grad school but all are welcome to apply 🧪
recruit.ucsc.edu/JPF01882

Sign up & spread the word to trainees about the 🪱C. elegans🪱 mentor match program!
They're also setting up peer-mentoring groups at ALL stages (even faculty!). Peer mentors have helped me keep my sanity & resolve in the tough times, and cheered me on in the good times. 🙌 Sign up to find your own!

Congrats David and team! 🎉

This is the first movement from Sen. Fetterman, please fill out immediately if you have been impacted. Please circulate Penn, Pitt, PSU, Temple etc @cbartman.bsky.social

Congrats Soni, Pallavi and team!

My lab strives to reduce infertility, miscarriages, and birth defects. We want y’all to have healthy kids.

I know it sounds weird, but indirect costs pay for lights, HVAC, maintenance, cleaning, safety, and admin.

It’s really hard to reduce birth defects in the dark.

Call your representatives

Congrats!

Join the Starr-Luxton lab & friends at #ASCB2024! Bringing exciting new research on nuclear envelope dynamics and cytoskeletal crosstalk.
2 Talks + 3 Posters, Dec 15-16 in San Diego
Topics: KASH proteins, motor proteins, nuclear movement & cellular biophysics!

Re-upping this announcement with a newer version of our flyer! Looking for a supportive & interdisciplinary training environment? Apply here!👉bit.ly/3VwZL29

Feel free to reach out to me or any faculty member whose research inspires you! Worried about the application fee? Let us know—we may be able to help! #GradSchool

Flyer for the Biological Sciences PhD Program at Lehigh University, with images highlighting the diverse research being carried out in this program. Application deadline Jan 1st, 2025.

🚨The deadline to apply for Lehigh University’s Biological Sciences PhD program is just a few weeks away! Are you (or do you know) an amazing undergrad, post-bac, or master’s student passionate about science & ready to thrive in a supportive, interdisciplinary environment? Apply here!👉bit.ly/3VwZL29

See you in SD María!

We have a fantastic lineup of speakers covering the latest in the field, including featured talks from trainees and early career faculty! Also be sure to check out the upcoming TWO Meiosis Poster sessions (Sunday Dec 15, 11:15 am & 1:30pm; Mon Dec 16, 11:15am & 1:30pm)! Can't wait to see you there!

This is an annual installment of our Special Interest Subgroup focusing on Meiosis and Reproductive Cell Biology during Cell Bio, co-organized by @needhibhalla.bsky.social‬, @lacefieldlab.bsky.social and myself since 2022! #Meiosis4Eva #meiosis4ever

A poster of the #Meiosis4Eva Special Interest Subgroup at Cell Bio 2024, with speaker names, affiliations and titles of their talks.

Heading to sunny San Diego for #CellBio2024 this week? ☀️🌅 Join us for the "#Meiosis4Eva: Frontiers in Meiosis and Germ Cell Biology" Subgroup! 🗓️ Wed Dec 18th 9:00 - 10:30am, Room 33B. 👉 bit.ly/49okQkZ #Meiosis4Eva #meiosis4ever

Thanks Wynn and so glad to finally see you here!!! Look forward to more coffee and more evolution chats!!

Thanks Julie! Look forward to more chats on channels!

Thank you Sam!!! Our 3i arrived just in time before Thanksgiving! Exciting times to get the imaging started!

Thank you!

Thank you Xin!

Thanks Swathi!

Thanks Chloe!!! Go #Meiosis4Eva!

Thanks Needhi!!!

🙏 Huge thanks to the many 🪱 colleagues without whom these findings would not have been possible, to the reviewers and to the amazing #Meiosis4Eva community, for sharing your insights and feedback every step of the way💡! Stay tuned as we keep unraveling the mysteries of meiosis! 💜✨ End of 🧵. 10/10

🛠️ Our CIP system is not just a tool for studying meiotic quality control: It offers a powerful way to relocalize proteins in live animals, opening up new avenues for probing many cell biology questions in diverse organisms. 9/10

A Piezo-dependent checkpoint mechanism at the nuclear envelope monitors oocyte quality. Pairing, synapsis, and recombination between homologous chromosomes are essential for accurate meiotic chromosome segregation. In C. elegans, synapsis failure promotes apoptosis of affected oocytes. After synapsis defects occur, PLK-2 persists at the pairing centers (1) and phosphorylates the nuclear lamin (2). This destabilizes the nuclear envelope and triggers Piezo–dependent apoptosis (3).

Together, our findings provide direct evidence of a mechanosensitive ion channel in detecting/responding to events originating in the oocyte nucleus. This suggests a new surveillance mechanism and sets up the stage for exploring how the dynamic nuclear envelope promotes meiotic quality control. 8/10

GFP-tagged PEZO-1 protein in C. elegans gonad localizes to both the plasma membrane and the nuclear envelope of oocytes.

Redistribution of PEZO-1 at the oocyte nuclear envelope depends on PCH-2/TRIP13.

Mechanosensitive channel PEZO-1 spreads across the nuclear envelope of late pachytene oocytes but redistributes to form clusters/foci during synapsis checkpoint activation. Interestingly, this redistribution depends on PCH-2/TRIP13, a conserved AAA+ATPase important to meiosis in many organisms. 7/10