Koeberle Lab

Excited to share our latest publication in which we uncover a link between ether phospholipid degradation and lipid mediator biosynthesis! This collaboration with the Katrin Watschinger lab provides new insights on sex-dependent lipid metabolism and signaling.

rdcu.be/epE1w

Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1 | PNAS FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...

Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
1/9

Online now - the Review "The metabolic code of #ferroptosis: nutritional regulators of cell death" from @angelifriedmann.bsky.social @k-hadian.bsky.social and colleagues.

#LipidPeroxidation #Nutrients #Metabolites #Vitamins #Lipids

Read it here 👉 authors.elsevier.com/sd/article/S...

Humbled to receive the 2025 Beatriz Manz Award from UC Berkeley. Thank you for this honor! 🙏 ☺️
ls.berkeley.edu/news/uc-berk...

📢 Only one more week to apply!

Cell membranes sustain phospholipid imbalance via cholesterol asymmetry This work challenges a major assumption in cell biology by showing that lipid bilayers can have drastically different phospholipid abundances between their two leaflets. This lipid abundance asymmetry...

Groundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...

We are looking for a PhD candidate in molecular biology / biochemistry / chemical biology with a passion for drug discovery to join our young and enthusiastic team @univie.ac.at. For details, visit: vds-phanuspo.univie.ac.at/application/.... Reposts are very much appreciated!

🧫 Ein internationales Forschungsteam rund um Andreas Koeberle hat einen Mechanismus entdeckt, der neue Behandlungsstrategien für Tumore eröffnet, bei denen konventionelle Chemotherapeutika an ihre Grenzen stoßen:
🔗 www.uni-graz.at/de/neuigkeit...

#weworkfortomorrow

💊 Dem Leberfett zu Leibe gerückt: Die Uni-Graz-Pharmakognostin Solveigh Koeberle forscht an neuen Medikamenten für degenerative Erkrankungen. www.uni-graz.at/de/neuigkeit...

Curious about the interplay between #apoptosis and #ferroptosis and their role in cytotoxic stress, whether induced by drugs or serum depletion? Check out our latest paper in #NatureCommunications.

rdcu.be/ebbYX

@unigraz #CellDeath #LipidMetabolism

Schedule of speakers at the 2025 FASEB Ferroptosis conference

Registration is open for our summer FASEB #Ferroptosis Conference July 27 - 31, 2025. We have a terrific line up of speakers and it's going to be amazzzing! Come join us for this historic first meeting! Please help us to spread the word. 🤩
shorturl.at/QA6T1

Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation - Nature Metabolism Snaebjornsson et al. explore a selective vulnerability in cancer elicited by targeting aldolase A, which causes energy imbalance and prevents further metabolic adaptations.

Happy to share our work on the mechanism of glycolysis in cancer now published in the journal Nature Metabolism. This was a large part of my postdoctoral work carried out in the lab of Prof. @almutschulze.bsky.social at the @dkfz.bsky.social and at Uni Wuerzburg.

www.nature.com/articles/s42...

PhD Student in Lipid Metabolism in Cancer

Excited to announce two DFG-funded PhD positions to study Lipid Droplet Heterogeneity in cancer as part of FOR5815. Join us @dkfz-heidelberg if you are interested in #cancermetabolism and #lipidbiology

jobs.dkfz.de/en/jobs/1673...

jobs.dkfz.de/de/jobs/1673...

Looking for exciting opportunities? 🎓 Apply for PhD positions in my lab and others in this fantastic program! 🚀
If you're seeking a postdoc or senior lab scientist role, feel free to DM or email me. Let's connect!
@imprs-cbp.bsky.social #PhDPositions #PostdocJobs

Published in the current edition of #MolCell ours and Marcus Conrad group study made the cover 🤩

Different biology converging on the newly identified role of #Prdx6 acting as a selenium carrier protein

🌕🌖🌗🌘🌑🌒🌓🌔🌕