Stefan Emming

😻 that is the content I am actually here for!

Don't see this too much around here yet but Bluesky supports labels to add to your posts, similar to the flairs on reddit and it's an easy way to display pronouns with your posts:
bsky.app/profile/pron...

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...

Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm

$1945 to get your own sci-fi short story published with an impact factor. Will consider in the future.

Getting busy here... hope soon a critical mass is reached.

The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axis NLRP3 is widely regarded as a sensor for ionic flux because most NLRP3 activators do so via potassium efflux. Holley, Emming et al. report that the septin modifier FCF induces septin-2 rearrangement a...

Quite a quick turnaround for this small story from us: Turns out that messing up septins activates NLRP3.
www.cell.com/cell-chemica...

That story took a looong time spanning multiple Honours and PhD projects, but finally here we are (and it even made the cover!:

NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome

www.science.org/doi/10.1126/...

Australia being ‘left behind’ as federal research and development funding sinks to 30-year low Technology experts sound the alarm as authorities try to encourage private investment

Do all the reviews you want, but the bottom line has been obvious for 10+ years.

"We urgently need publicly funded scientists doing essential research for overall public benefit & a nice social media strategy doesn’t make that happen – funding does."

www.theguardian.com/business/202...

Meme pattern, dog sitting in a burning house saying "this is fine"

Australia being ‘left behind’ as federal research and development funding sinks to 30-year low

www.theguardian.com/business/202...

Biology is never simple ! I’m happy to share our new publication on the role of HDAC6 on inflammasome. We used several methods (KO mouse, inhibitors, DARPIN…) to show that HDAC6 is NOT always driving the inflammasome and is context-dependent. DOI:https://doi.org/10.1016/j.jbc.2024.105638

#DiscoveryProjects

For those who missed the ARC's (technically challenged) presentation about the EOI stage of #DP25 yesterday, the recording is at youtu.be/gEFrZABjVPQ

link.springer.com/article/10.1...

"The “Free lunches” index for assessing academics: a not entirely serious proposal"

Love this one, I feel some basic researchers would also be quite high up on the list.

There is so much coming out on NLRP1 and I still have a lot of questionmarks on how this all is regulated 😵‍💫

Don't think bluesky made it down under yet, but better get started:

I am a postdoc in Kates Inflammasomelab @IMB @University of Queensland and interested in all inflammasomey things especially NLRP3 and novel inhibitors